Two novel phosphatidylinositol-4-phosphate 5-kinase type Igamma splice variants expressed in human cells display distinctive cellular targeting.
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IQGAP1 is a novel phosphatidylinositol 4,5 bisphosphate effector in regulation of directional cell migration.Phosphoinositide signaling regulates the exocyst complex and polarized integrin trafficking in directionally migrating cellsNuclear PI3K signaling in cell growth and tumorigenesisPhosphoinositides: tiny lipids with giant impact on cell regulationPIP kinases define PI4,5P₂signaling specificity by association with effectorsEmerging roles of PtdIns(4,5)P2--beyond the plasma membraneCinderella story: PI4P goes from precursor to key signaling moleculeLAPTM4B is a PtdIns(4,5)P2 effector that regulates EGFR signaling, lysosomal sorting, and degradation.Isoform 5 of PIPKIγ regulates the endosomal trafficking and degradation of E-cadherin.Nuclear phosphoinositides: a signaling enigma wrapped in a compartmental conundrum.Type I gamma phosphatidylinositol phosphate kinase modulates invasion and proliferation and its expression correlates with poor prognosis in breast cancer.Phosphatidylinositol 4,5-bisphosphate: targeted production and signalingTargeting type Iγ phosphatidylinositol phosphate kinase inhibits breast cancer metastasisPhosphatidylinositol Phosphate 5-Kinase Iγ and Phosphoinositide 3-Kinase/Akt Signaling Couple to Promote Oncogenic Growth.Phosphatidylinositol-4-phosphate 5-kinase isoforms exhibit acyl chain selectivity for both substrate and lipid activatorPhosphatidic acid regulation of PIPKI is critical for actin cytoskeletal reorganization.Endosomal type Iγ PIP 5-kinase controls EGF receptor lysosomal sortingPtdIns(4,5)P2 signaling regulates ATG14 and autophagyPhosphatidylinositol phosphate 5-kinase Iγi2 in association with Src controls anchorage-independent growth of tumor cells.Protein Kinase D1 regulates focal adhesion dynamics and cell adhesion through Phosphatidylinositol-4-phosphate 5-kinase type-l γ.PIPKIγ targets to the centrosome and restrains centriole duplication.Regulation of PIP5K activity by Arf6 and its physiological significance.Nuclear phosphoinositides and their roles in cell biology and disease.Phosphatidylinositol 4-phosphate 5-kinase Iγ_v6, a new splice variant found in rodents and humans.IQGAP1 is a phosphoinositide effector and kinase scaffoldNuclear Phosphatidylinositol Signaling: Focus on Phosphatidylinositol Phosphate Kinases and Phospholipases C.Agonist-stimulated phosphatidylinositol-3,4,5-trisphosphate generation by scaffolded phosphoinositide kinases.Type I γ Phosphatidylinositol Phosphate 5-Kinase i5 Controls the Ubiquitination and Degradation of the Tumor Suppressor Mitogen-inducible Gene 6FAK, talin and PIPKIγ regulate endocytosed integrin activation to polarize focal adhesion assembly.Integrin adhesion and force coupling are independently regulated by localized PtdIns(4,5)2 synthesis.Tools for visualization of phosphoinositides in the cell nucleus.PIPKIγ regulates β-catenin transcriptional activity downstream of growth factor receptor signaling.Type Iγ phosphatidylinositol phosphate kinase regulates PD-L1 expression by activating NF-κB.EGFR-induced phosphorylation of type Iγ phosphatidylinositol phosphate kinase promotes pancreatic cancer progression.Localization and projected role of phosphatidylinositol 4-kinases IIα and IIβ in inositol 1,4,5-trisphosphate-sensitive nucleoplasmic Ca²⁺ store vesicles.Smurf1 regulates lung cancer cell growth and migration through interaction with and ubiquitination of PIPKIγ.Phosphoinositide 3-kinase pathways and autophagy require phosphatidylinositol phosphate kinases.Type I phosphatidylinositol 4-phosphate 5-kinase γ is required for neuronal migration in the mouse developing cerebral cortex.
P2860
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P2860
Two novel phosphatidylinositol-4-phosphate 5-kinase type Igamma splice variants expressed in human cells display distinctive cellular targeting.
description
article científic
@ca
article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 27 August 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Two novel phosphatidylinositol ...... istinctive cellular targeting.
@en
Two novel phosphatidylinositol ...... istinctive cellular targeting.
@nl
type
label
Two novel phosphatidylinositol ...... istinctive cellular targeting.
@en
Two novel phosphatidylinositol ...... istinctive cellular targeting.
@nl
prefLabel
Two novel phosphatidylinositol ...... istinctive cellular targeting.
@en
Two novel phosphatidylinositol ...... istinctive cellular targeting.
@nl
P2860
P356
P1433
P1476
Two novel phosphatidylinositol ...... istinctive cellular targeting.
@en
P2093
Nicholas J Schill
Richard A Anderson
P2860
P304
P356
10.1042/BJ20090638
P407
P577
2009-08-27T00:00:00Z