Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover
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Structural basis of drug binding to CYP46A1, an enzyme that controls cholesterol turnover in the brainCholesterol 24-hydroxylase: an enzyme of cholesterol turnover in the brain24S-hydroxycholesterol effects on lipid metabolism genes are modeled in traumatic brain injuryLinking lipids, Alzheimer's and LXRs?Inhibiting cholesterol degradation induces neuronal sclerosis and epileptic activity in mouse hippocampus.In Silico and Intuitive Predictions of CYP46A1 Inhibition by Marketed Drugs with Subsequent Enzyme Crystallization in Complex with FluvoxamineAntifungal Azoles: Structural Insights into Undesired Tight Binding to Cholesterol-Metabolizing CYP46A1Cytochrome P450s in the synthesis of cholesterol and bile acids--from mouse models to human diseases.Inactivation of liver X receptor beta leads to adult-onset motor neuron degeneration in male miceSIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesisCholesterol-24S-hydroxylase (CYP46A1) is specifically expressed in neurons of the neural retinaHistone deacetylase inhibition decreases cholesterol levels in neuronal cells by modulating key genes in cholesterol synthesis, uptake and effluxABCG1 and ABCG4 are coexpressed in neurons and astrocytes of the CNS and regulate cholesterol homeostasis through SREBP-2Sulphatation does not appear to be a protective mechanism to prevent oxysterol accumulation in humans and miceLiver X receptors regulate cholesterol homeostasis in oligodendrocytesThe effect of 24S-hydroxycholesterol on cholesterol homeostasis in neurons: quantitative changes to the cortical neuron proteomeDisturbed cholesterol homeostasis in a peroxisome-deficient PEX2 knockout mouse modelFlux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathwaysThe Major Brain Cholesterol Metabolite 24(S)-Hydroxycholesterol Is a Potent Allosteric Modulator of N-Methyl-D-Aspartate ReceptorsA suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett syndrome.Brain cholesterol turnover required for geranylgeraniol production and learning in mice.Specific loss of brain ABCA1 increases brain cholesterol uptake and influences neuronal structure and function.Differential expression and function of ABCG1 and ABCG4 during development and aging.Survival of adult neurons lacking cholesterol synthesis in vivo.Selective reconstitution of liver cholesterol biosynthesis promotes lung maturation but does not prevent neonatal lethality in Dhcr7 null mice.The antifungal drug voriconazole is an efficient inhibitor of brain cholesterol 24S-hydroxylase in vitro and in vivoNeuronal expression and subcellular localization of cholesterol 24-hydroxylase in the mouse brainACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD.Cholesterol in the retina: the best is yet to come.Constitutive hippocampal cholesterol loss underlies poor cognition in old rodents.Retinal and nonocular abnormalities in Cyp27a1(-/-)Cyp46a1(-/-) mice with dysfunctional metabolism of cholesterol.The use of the Dhcr7 knockout mouse to accurately determine the origin of fetal sterols.Central nervous system: cholesterol turnover, brain development and neurodegeneration.Is it possible to improve memory function by upregulation of the cholesterol 24S-hydroxylase (CYP46A1) in the brain?Function and comorbidities of apolipoprotein e in Alzheimer's disease.Interaction between positive allosteric modulators and trapping blockers of the NMDA receptor channel.Mutation of beta-glucosidase 2 causes glycolipid storage disease and impaired male fertilityCholestenoic acids regulate motor neuron survival via liver X receptors.Cholesterol: from heart attacks to Alzheimer's disease.Cholesterol metabolism and homeostasis in the brain
P2860
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P2860
Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover
description
2003 nî lūn-bûn
@nan
2003 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Knockout of the cholesterol 24 ...... hanism of cholesterol turnover
@ast
Knockout of the cholesterol 24 ...... hanism of cholesterol turnover
@en
Knockout of the cholesterol 24 ...... hanism of cholesterol turnover
@nl
type
label
Knockout of the cholesterol 24 ...... hanism of cholesterol turnover
@ast
Knockout of the cholesterol 24 ...... hanism of cholesterol turnover
@en
Knockout of the cholesterol 24 ...... hanism of cholesterol turnover
@nl
prefLabel
Knockout of the cholesterol 24 ...... hanism of cholesterol turnover
@ast
Knockout of the cholesterol 24 ...... hanism of cholesterol turnover
@en
Knockout of the cholesterol 24 ...... hanism of cholesterol turnover
@nl
P2093
P3181
P356
P1476
Knockout of the cholesterol 24 ...... hanism of cholesterol turnover
@en
P2093
Chonglun Xie
Erik G Lund
John M Dietschy
Stephen D Turley
Tiina Kotti
P304
22980-22988
P3181
P356
10.1074/JBC.M303415200
P407
P577
2003-04-09T00:00:00Z