A novel ubiquitin fusion system bypasses the mitochondria and generates biologically active Smac/DIABLO - Wikidata - wikimedia - TriplyDB

A novel ubiquitin fusion system bypasses the mitochondria and generates biologically active Smac/DIABLO

A novel ubiquitin fusion system bypasses the mitochondria and generates biologically active Smac/DIABLO

http://www.wikidata.org/entity/Q28201640

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OTULIN restricts Met1-linked ubiquitination to control innate immune signaling Characterization of COMMD protein-protein interactions in NF-kappaB signalling Small molecules destabilize cIAP1 by activating auto-ubiquitylation Neuronal apoptosis-inhibitory protein does not interact with Smac and requires ATP to bind caspase-9 Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function Amsacta moorei Entomopoxvirus inhibitor of apoptosis suppresses cell death by binding Grim and Hid Monomerization of cytosolic mature smac attenuates interaction with IAPs and potentiation of caspase activation Nuclear factor-κB-inducing kinase (NIK) contains an amino-terminal inhibitor of apoptosis (IAP)-binding motif (IBM) that potentiates NIK degradation by cellular IAP1 (c-IAP1).BID-dependent release of mitochondrial SMAC dampens XIAP-mediated immunity against Shigella.Inhibitor of apoptosis proteins: new therapeutic targets in hematological cancer?Apoptosis-inducing factor is a target for ubiquitination through interaction with XIAP.Substrates of IAP ubiquitin ligases identified with a designed orthogonal E3 ligase, the NEDDylator Inhibitor of apoptosis proteins as targets for anticancer therapy.Enhanced protein expression in the baculovirus/insect cell system using engineered SUMO fusions.Two distinct signalling cascades target the NF-kappaB regulatory factor c-IAP1 for degradation.XIAP inhibits mature Smac-induced apoptosis by degrading it through ubiquitination in NSCLC.Differential regulation of Smac/DIABLO and Hsp-70 during brain maturation Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signalling.A bimolecular affinity purification method under denaturing conditions for rapid isolation of a ubiquitinated protein for mass spectrometry analysis.TRAIL-activated stress kinases suppress apoptosis through transcriptional upregulation of MCL-1.Neutralization of Smac/Diablo by inhibitors of apoptosis (IAPs). A caspase-independent mechanism for apoptotic inhibition.Real-time single cell analysis of Smac/DIABLO release during apoptosis.The E3 ubiquitin ligase cIAP1 binds and ubiquitinates caspase-3 and -7 via unique mechanisms at distinct steps in their processing.Smac/DIABLO selectively reduces the levels of c-IAP1 and c-IAP2 but not that of XIAP and livin in HeLa cells.Caspase activation and apoptosis in response to proteasome inhibitors.A GH3-like domain in reaper is required for mitochondrial localization and induction of IAP degradation.Differentiation-dependent sensitivity to apoptogenic factors in PC12 cells.Sox2 protects neural stem cells from apoptosis via up-regulating survivin expression.The saintly side of Smac/DIABLO: giving anticancer drug-induced apoptosis a boost

P2860

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P2860

A novel ubiquitin fusion system bypasses the mitochondria and generates biologically active Smac/DIABLO

http://www.wikidata.org/entity/Q28201640

description

2003 nî lūn-bûn

@nan

2003 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2003年の論文

@ja

2003年論文

@yue

2003年論文

@zh-hant

2003年論文

@zh-hk

2003年論文

@zh-mo

2003年論文

@zh-tw

2003年论文

@wuu

name

A novel ubiquitin fusion syste ...... iologically active Smac/DIABLO

@ast

A novel ubiquitin fusion syste ...... iologically active Smac/DIABLO

@en

A novel ubiquitin fusion syste ...... iologically active Smac/DIABLO

@nl

type

label

A novel ubiquitin fusion syste ...... iologically active Smac/DIABLO

@ast

A novel ubiquitin fusion syste ...... iologically active Smac/DIABLO

@en

A novel ubiquitin fusion syste ...... iologically active Smac/DIABLO

@nl

prefLabel

A novel ubiquitin fusion syste ...... iologically active Smac/DIABLO

@ast

A novel ubiquitin fusion syste ...... iologically active Smac/DIABLO

@en

A novel ubiquitin fusion syste ...... iologically active Smac/DIABLO

@nl

P1433

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P1433

Journal of Biological Chemistry

P1476

A novel ubiquitin fusion syste ...... iologically active Smac/DIABLO

@en

P2093

Allison M Hunter

http://www.w3.org/2001/XMLSchema#string

Colin S Duckett

http://www.w3.org/2001/XMLSchema#string

Dan Kottachchi

http://www.w3.org/2001/XMLSchema#string

Jennifer Lewis

http://www.w3.org/2001/XMLSchema#string

Peter Liston

http://www.w3.org/2001/XMLSchema#string

Robert G Korneluk

http://www.w3.org/2001/XMLSchema#string

P2860

The Hallmarks of Cancer

Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway

A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death

The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif

HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins

The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction

Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death

The inhibitor of apoptosis protein-binding domain of Smac is not essential for its proapoptotic activity

Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

Structural basis of IAP recognition by Smac/DIABLO

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7494-9

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scholarly article

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4276796

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10.1074/JBC.C200695200

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9

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278

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2003-02-28T00:00:00Z

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12511567

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