Role of Cbfb in hematopoiesis and perturbations resulting from expression of the leukemogenic fusion gene Cbfb-MYH11
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Cbfbeta interacts with Runx2 and has a critical role in bone developmentAccelerated leukemogenesis by truncated CBF beta-SMMHC defective in high-affinity binding with RUNX1Megakaryocytic programming by a transcriptional regulatory loop: A circle connecting RUNX1, GATA-1, and P-TEFb.Transcriptional control of megakaryocyte development.Down-regulation of microRNAs 222/221 in acute myelogenous leukemia with deranged core-binding factor subunitsmiR-125b, a target of CDX2, regulates cell differentiation through repression of the core binding factor in hematopoietic malignancies.CBFB-MYH11 hinders early T-cell development and induces massive cell death in the thymusLoss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype.Animal models of acute myelogenous leukaemia - development, application and future perspectives.MicroRNA-125b transforms myeloid cell lines by repressing multiple mRNA.Cbfbeta-SMMHC impairs differentiation of common lymphoid progenitors and reveals an essential role for RUNX in early B-cell development.The C-terminus of CBFβ-SMMHC is required to induce embryonic hematopoietic defects and leukemogenesisNormal and malignant megakaryopoiesis.Review: genetic models of acute myeloid leukaemia.Dysregulation of the transcription factors SOX4, CBFB and SMARCC1 correlates with outcome of colorectal cancer.Human CD34+ cells expressing the inv(16) fusion protein exhibit a myelomonocytic phenotype with greatly enhanced proliferative ability.Lymphoid enhancer factor-1 links two hereditary leukemia syndromes through core-binding factor alpha regulation of ELA2.Knockdown of Hnrnpa0, a del(5q) gene, alters myeloid cell fate in murine cells through regulation of AU-rich transcripts.CBFB and MYH11 in inv(16)(p13q22) of acute myeloid leukemia displaying close spatial proximity in interphase nuclei of human hematopoietic stem cells.T-lymphoid, megakaryocyte, and granulocyte development are sensitive to decreases in CBFbeta dosage.Recurrent Fusion Genes in Leukemia: An Attractive Target for Diagnosis and Treatment.
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P2860
Role of Cbfb in hematopoiesis and perturbations resulting from expression of the leukemogenic fusion gene Cbfb-MYH11
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2002 nî lūn-bûn
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2002 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
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2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
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name
Role of Cbfb in hematopoiesis ...... mogenic fusion gene Cbfb-MYH11
@ast
Role of Cbfb in hematopoiesis ...... mogenic fusion gene Cbfb-MYH11
@en
Role of Cbfb in hematopoiesis ...... mogenic fusion gene Cbfb-MYH11
@nl
type
label
Role of Cbfb in hematopoiesis ...... mogenic fusion gene Cbfb-MYH11
@ast
Role of Cbfb in hematopoiesis ...... mogenic fusion gene Cbfb-MYH11
@en
Role of Cbfb in hematopoiesis ...... mogenic fusion gene Cbfb-MYH11
@nl
prefLabel
Role of Cbfb in hematopoiesis ...... mogenic fusion gene Cbfb-MYH11
@ast
Role of Cbfb in hematopoiesis ...... mogenic fusion gene Cbfb-MYH11
@en
Role of Cbfb in hematopoiesis ...... mogenic fusion gene Cbfb-MYH11
@nl
P2093
P1433
P1476
Role of Cbfb in hematopoiesis ...... mogenic fusion gene Cbfb-MYH11
@en
P2093
David Bodine
Lucio H Castilla
Martha Kirby
Pu Paul Liu
Stacie Anderson
P304
P356
10.1182/BLOOD-2002-04-1064
P407
P577
2002-10-01T00:00:00Z