Human CD34+ cells expressing the inv(16) fusion protein exhibit a myelomonocytic phenotype with greatly enhanced proliferative ability. - Wikidata - wikimedia - TriplyDB

Human CD34+ cells expressing the inv(16) fusion protein exhibit a myelomonocytic phenotype with greatly enhanced proliferative ability.

Human CD34+ cells expressing the inv(16) fusion protein exhibit a myelomonocytic phenotype with greatly enhanced proliferative ability.

http://www.wikidata.org/entity/Q38288838

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In vitro transformation of primary human CD34+ cells by AML fusion oncogenes: early gene expression profiling reveals possible drug target in AML Accelerated leukemogenesis by truncated CBF beta-SMMHC defective in high-affinity binding with RUNX1 DNA methylation profiles and their relationship with cytogenetic status in adult acute myeloid leukemia.AML xenograft efficiency is significantly improved in NOD/SCID-IL2RG mice constitutively expressing human SCF, GM-CSF and IL-3.Rapid generation of human B-cell lymphomas via combined expression of Myc and Bcl2 and their use as a preclinical model for biological therapies.UMG Lenti: novel lentiviral vectors for efficient transgene- and reporter gene expression in human early hematopoietic progenitors.Establishment of a human multiple myeloma xenograft model in the chicken to study tumor growth, invasion and angiogenesis.The thrombopoietin/MPL/Bcl-xL pathway is essential for survival and self-renewal in human preleukemia induced by AML1-ETO.p53 signaling in response to increased DNA damage sensitizes AML1-ETO cells to stress-induced death UBASH3B/Sts-1-CBL axis regulates myeloid proliferation in human preleukemia induced by AML1-ETO.Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia.Review: genetic models of acute myeloid leukaemia.Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells Supraphysiologic levels of the AML1-ETO isoform AE9a are essential for transformation.Genetic hierarchy and temporal variegation in the clonal history of acute myeloid leukaemia.Core binding factor at the crossroads: determining the fate of the HSC.Molecular pathogenesis of core binding factor leukemia: current knowledge and future prospects.Mouse models for core binding factor leukemia.Protease-activated receptor-1 inhibits proliferation but enhances leukemia stem cell activity in acute myeloid leukemia.Transcriptional dysregulation mediated by RUNX1-RUNX1T1 in normal human progenitor cells and in acute myeloid leukaemia.Model systems for examining effects of leukemia-associated oncogenes in primary human CD34+ cells via retroviral transduction.MN1 overexpression is driven by loss of DNMT3B methylation activity in inv(16) pediatric AML.

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P2860

Human CD34+ cells expressing the inv(16) fusion protein exhibit a myelomonocytic phenotype with greatly enhanced proliferative ability.

http://www.wikidata.org/entity/Q38288838

description

2006 nî lūn-bûn

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2006年の論文

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2006年学术文章

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2006年学术文章

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2006年学术文章

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2006年学术文章

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2006年学术文章

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2006年學術文章

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2006年學術文章

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2006年學術文章

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name

Human CD34+ cells expressing t ...... nhanced proliferative ability.

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type

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Human CD34+ cells expressing t ...... nhanced proliferative ability.

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Human CD34+ cells expressing t ...... nhanced proliferative ability.

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BLOOD-2005-12-012773

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Human CD34+ cells expressing t ...... nhanced proliferative ability.

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P2093

James C Mulloy

http://www.w3.org/2001/XMLSchema#string

Junping Wei

http://www.w3.org/2001/XMLSchema#string

Mark Wunderlich

http://www.w3.org/2001/XMLSchema#string

Ondrej Krejci

http://www.w3.org/2001/XMLSchema#string

P2860

Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia

Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis

Role of Cbfb in hematopoiesis and perturbations resulting from expression of the leukemogenic fusion gene Cbfb-MYH11

AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis

Plag1 and Plagl2 are oncogenes that induce acute myeloid leukemia in cooperation with Cbfb-MYH11

Hematopoiesis in the fetal liver is impaired by targeted mutagenesis of a gene encoding a non-DNA binding subunit of the transcription factor, polyomavirus enhancer binding protein 2/core binding factor

Absence of fetal liver hematopoiesis in mice deficient in transcriptional coactivator core binding factor beta.

AML1-ETO fusion protein up-regulates TRKA mRNA expression in human CD34+ cells, allowing nerve growth factor-induced expansion.

Acute myeloid leukemias with reciprocal rearrangements can be distinguished by specific gene expression profiles

Use of gene-expression profiling to identify prognostic subclasses in adult acute myeloid leukemia.

P304

1690-1697

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scholarly article

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10.1182/BLOOD-2005-12-012773

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7110861

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16670269

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1586104

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