Cbfbeta-SMMHC impairs differentiation of common lymphoid progenitors and reveals an essential role for RUNX in early B-cell development.
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Engineering mouse models with myelodysplastic syndrome human candidate genes; how relevant are they?Molecular Basis and Targeted Inhibition of CBFβ-SMMHC Acute Myeloid Leukemia.Compound haploinsufficiencies of Ebf1 and Runx1 genes impede B cell lineage progressionCBFβ and the leukemogenic fusion protein CBFβ-SMMHC associate with mitotic chromosomes to epigenetically regulate ribosomal genesEctopic Runx1 expression rescues Tal-1-deficiency in the generation of primitive and definitive hematopoiesis.HDAC8 Inhibition Specifically Targets Inv(16) Acute Myeloid Leukemic Stem Cells by Restoring p53 AcetylationRegain control of p53: Targeting leukemia stem cells by isoform-specific HDAC inhibitionEarly B cell factor: Regulator of B lineage specification and commitmentCharged Amino Acid-rich Leucine Zipper-1 (Crlz-1) as a Target of Wnt Signaling Pathway Controls Pre-B Cell Proliferation by Affecting Runx/CBFβ-targeted VpreB and λ5 Genes.A germline point mutation in Runx1 uncouples its role in definitive hematopoiesis from differentiationSignaling proteins and transcription factors in normal and malignant early B cell development.CBFβ-SMMHC creates aberrant megakaryocyte-erythroid progenitors prone to leukemia initiation in mice.The assembly competence domain is essential for inv(16)-associated acute myeloid leukemia.Preleukemia and Leukemia-Initiating Cell Activity in inv(16) Acute Myeloid Leukemia.Modelling acute myeloid leukaemia in a continuum of differentiation states
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P2860
Cbfbeta-SMMHC impairs differentiation of common lymphoid progenitors and reveals an essential role for RUNX in early B-cell development.
description
2007 nî lūn-bûn
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2007年の論文
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2007年学术文章
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2007年学术文章
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2007年学术文章
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2007年学术文章
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2007年学术文章
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2007年學術文章
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2007年學術文章
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2007年學術文章
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name
Cbfbeta-SMMHC impairs differen ...... X in early B-cell development.
@ast
Cbfbeta-SMMHC impairs differen ...... X in early B-cell development.
@en
type
label
Cbfbeta-SMMHC impairs differen ...... X in early B-cell development.
@ast
Cbfbeta-SMMHC impairs differen ...... X in early B-cell development.
@en
prefLabel
Cbfbeta-SMMHC impairs differen ...... X in early B-cell development.
@ast
Cbfbeta-SMMHC impairs differen ...... X in early B-cell development.
@en
P2093
P2860
P1433
P1476
Cbfbeta-SMMHC impairs differen ...... X in early B-cell development.
@en
P2093
Lucio H Castilla
Rachel M Gerstein
Ya-Huei Kuo
P2860
P304
P356
10.1182/BLOOD-2007-07-104422
P407
P577
2007-10-16T00:00:00Z