WWOX, the common chromosomal fragile site, FRA16D, cancer gene
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Inhibition of the Wnt/beta-catenin pathway by the WWOX tumor suppressor proteinWWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteinsFrequent downregulation and loss of WWOX gene expression in human hepatocellular carcinomaWWOX protein expression varies among ovarian carcinoma histotypes and correlates with less favorable outcomeCommon fragile sites: genomic hotspots of DNA damage and carcinogenesisRole of DLC1 tumor suppressor gene and MYC oncogene in pathogenesis of human hepatocellular carcinoma: potential prospects for combined targeted therapeutics (review)Senataxin, defective in the neurodegenerative disorder ataxia with oculomotor apraxia 2, lies at the interface of transcription and the DNA damage response.Generation and characterization of mice carrying a conditional allele of the Wwox tumor suppressor geneImpact of WWOX alterations on p73, ΔNp73, p53, cell proliferation and DNA ploidy in salivary gland neoplasms.Molecular alterations in the tumor suppressor gene WWOX in oral leukoplakias.WWOX hypomorphic mice display a higher incidence of B-cell lymphomas and develop testicular atrophy.WWOX protein expression in normal human tissues.Frequent loss of WWOX expression in breast cancer: correlation with estrogen receptor statusLow levels of WWOX protein immunoexpression correlate with tumour grade and a less favourable outcome in patients with urinary bladder tumours.WWOX at the crossroads of cancer, metabolic syndrome related traits and CNS pathologies.Conditional Wwox deletion in mouse mammary gland by means of two Cre recombinase approaches.Alteration of introns in a hyaluronan synthase 1 (HAS1) minigene convert Pre-mRNA [corrected] splicing to the aberrant pattern in multiple myeloma (MM): MM patients harbor similar changes.WW domain-containing oxidoreductase in neuronal injury and neurological diseases.Admixture fine-mapping in African Americans implicates XAF1 as a possible sarcoidosis risk geneWWOX in biological control and tumorigenesis.The JNK inhibitor SP600129 enhances apoptosis of HCC cells induced by the tumor suppressor WWOX.Genetic association study identifies a functional CNV in the WWOX gene contributes to the risk of intracranial aneurysms.Aberrant splice variants of HAS1 (Hyaluronan Synthase 1) multimerize with and modulate normally spliced HAS1 protein: a potential mechanism promoting human cancerReprogramming of a melanoma genome by nuclear transplantation.WWOX gene and gene product: tumor suppression through specific protein interactions.Signaling from membrane receptors to tumor suppressor WW domain-containing oxidoreductase.WWOX: a fragile tumor suppressor.WWOX, large common fragile site genes, and cancer.Nuclear localization of active HGF receptor Met in aggressive MDA-MB231 breast carcinoma cells.Expression of common chromosomal fragile site genes, WWOX/FRA16D and FHIT/FRA3B is downregulated by exposure to environmental carcinogens, UV, and BPDE but not by IR.Identification of a novel susceptibility locus at 16q23.1 associated with childhood acute lymphoblastic leukemia in Han Chinese.Recurrent alterations of the WW domain containing oxidoreductase gene spanning the common fragile site FRA16D in multiple myeloma and monoclonal gammopathy of undetermined significance.Characterization of the tumor suppressor gene WWOX in primary human oral squamous cell carcinomas.WWOX-related encephalopathies: delineation of the phenotypical spectrum and emerging genotype-phenotype correlation.RORA, a large common fragile site gene, is involved in cellular stress response.Tumor Suppressor Gene in Breast Cancer, a Historical Perspective and Future Directions
P2860
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P2860
WWOX, the common chromosomal fragile site, FRA16D, cancer gene
description
2003 nî lūn-bûn
@nan
2003 թուականին հրատարակուած գիտական յօդուած
@hyw
2003 թվականին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
WWOX, the common chromosomal fragile site, FRA16D, cancer gene
@ast
WWOX, the common chromosomal fragile site, FRA16D, cancer gene
@en
WWOX, the common chromosomal fragile site, FRA16D, cancer gene
@nl
type
label
WWOX, the common chromosomal fragile site, FRA16D, cancer gene
@ast
WWOX, the common chromosomal fragile site, FRA16D, cancer gene
@en
WWOX, the common chromosomal fragile site, FRA16D, cancer gene
@nl
prefLabel
WWOX, the common chromosomal fragile site, FRA16D, cancer gene
@ast
WWOX, the common chromosomal fragile site, FRA16D, cancer gene
@en
WWOX, the common chromosomal fragile site, FRA16D, cancer gene
@nl
P2093
P2860
P356
P1476
WWOX, the common chromosomal fragile site, FRA16D, cancer gene
@en
P2093
J H Ludes-Meyers
N C Popescu
P2860
P304
P356
10.1159/000072844
P407
P577
2003-01-01T00:00:00Z