LKB1--a master tumour suppressor of the small intestine and beyond
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MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasmNutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylationHeat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stabilityAmino acids as regulators of gene expressionMammographic density is related to stroma and stromal proteoglycan expressionActivation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases.Regulation of the Wnt signalling component PAR1A by the Peutz-Jeghers syndrome kinase LKB1Lactic acidosis triggers starvation response with paradoxical induction of TXNIP through MondoAIonizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366Identification of a Tumor Specific, Active-Site Mutation in Casein Kinase 1α by Chemical ProteomicsIntegrin-binding protein nischarin interacts with tumor suppressor liver kinase B1 (LKB1) to regulate cell migration of breast epithelial cells.Metabolic stress regulates cytoskeletal dynamics and metastasis of cancer cells.Population-based estimate of sibling risk for preterm birth, preterm premature rupture of membranes, placental abruption and pre-eclampsia.Lkb1 deficiency alters goblet and paneth cell differentiation in the small intestineEnhancing mTOR-targeted cancer therapy.High prevalence of germline STK11 mutations in Hungarian Peutz-Jeghers Syndrome patients.Genotype-phenotype correlations in Peutz-Jeghers syndromeFunctional analysis of Peutz-Jeghers mutations reveals that the LKB1 C-terminal region exerts a crucial role in regulating both the AMPK pathway and the cell polarity.The Snf1 protein kinase and Sit4 protein phosphatase have opposing functions in regulating TATA-binding protein association with the Saccharomyces cerevisiae INO1 promoter.Liver kinase B1 (LKB1) in the pathogenesis of epithelial cancersCharacterization of the STK11 splicing variant as a normal splicing isomer in a patient with Peutz-Jeghers syndrome harboring genomic deletion of the STK11 geneLKB1 induces apical trafficking of Silnoon, a monocarboxylate transporter, in Drosophila melanogasterReconstructing signal transduction pathways: challenges and opportunities.LKB1 is necessary for Akt-mediated phosphorylation of proapoptotic proteinsHomeostatic functions of the p53 tumor suppressor: regulation of energy metabolism and antioxidant defense.The molecular mechanisms that underlie the tumor suppressor function of LKB1.Regulation of protein synthesis by ionizing radiation.Novel mutations in the STK11 gene in Thai patients with Peutz-Jeghers syndrome.Adenosine Monophosphate-Activated Protein Kinase (AMPK) as a New Target for Antidiabetic Drugs: A Review on Metabolic, Pharmacological and Chemical Considerations.p53 regulation of the IGF-1/AKT/mTOR pathways and the endosomal compartment.LKB1 loss of function studied in vivo.The long and winding road to rational treatment of cancer associated with LKB1/AMPK/TSC/mTORC1 signaling.Cross-talk between AMPK and mTOR in regulating energy balance.AMPK and HIF signaling pathways regulate both longevity and cancer growth: the good news and the bad news about survival mechanisms.Genetics and genomics of ovarian sex cord-stromal tumors.LKB1 gene mutations in Japanese lung cancer patients.Restoration of silenced Peutz-Jeghers syndrome gene, LKB1, induces apoptosis in pancreatic carcinoma cells.AMPKα2 Suppresses Murine Embryonic Fibroblast Transformation and Tumorigenesis.Genetic and epigenetic profiling of a solitary Peutz-Jeghers colon polyp.The serine/threonine kinase LKB1 controls thymocyte survival through regulation of AMPK activation and Bcl-XL expression.
P2860
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P2860
LKB1--a master tumour suppressor of the small intestine and beyond
description
2002 nî lūn-bûn
@nan
2002 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
LKB1--a master tumour suppressor of the small intestine and beyond
@ast
LKB1--a master tumour suppressor of the small intestine and beyond
@en
LKB1--a master tumour suppressor of the small intestine and beyond
@nl
type
label
LKB1--a master tumour suppressor of the small intestine and beyond
@ast
LKB1--a master tumour suppressor of the small intestine and beyond
@en
LKB1--a master tumour suppressor of the small intestine and beyond
@nl
prefLabel
LKB1--a master tumour suppressor of the small intestine and beyond
@ast
LKB1--a master tumour suppressor of the small intestine and beyond
@en
LKB1--a master tumour suppressor of the small intestine and beyond
@nl
P2093
P3181
P356
P1476
LKB1--a master tumour suppressor of the small intestine and beyond
@en
P2093
Daniel C Chung
Junying Yuan
Lina I Yoo
P2888
P304
P3181
P356
10.1038/NRC843
P407
P577
2002-07-01T00:00:00Z
P6179
1008173109