Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability - Wikidata - wikimedia - TriplyDB

Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability

Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability

http://www.wikidata.org/entity/Q24535623

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STRAD pseudokinases regulate axogenesis and LKB1 stability MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1 STE20-related kinase adaptor protein α (STRADα) regulates cell polarity and invasion through PAK1 signaling in LKB1-null cells Drugging the cancer chaperone HSP90: combinatorial therapeutic exploitation of oncogene addiction and tumor stress Canonical and kinase activity-independent mechanisms for extracellular signal-regulated kinase 5 (ERK5) nuclear translocation require dissociation of Hsp90 from the ERK5-Cdc37 complex High prevalence of germline STK11 mutations in Hungarian Peutz-Jeghers Syndrome patients.Endurance training increases LKB1 and MO25 protein but not AMP-activated protein kinase kinase activity in skeletal muscle.Recent progress on liver kinase B1 (LKB1): expression, regulation, downstream signaling and cancer suppressive function.LKB1, a protein kinase regulating cell proliferation and polarity.Functional analysis of Peutz-Jeghers mutations reveals that the LKB1 C-terminal region exerts a crucial role in regulating both the AMPK pathway and the cell polarity.Structure of an Hsp90-Cdc37-Cdk4 complex.Role of the AMPK/SREBP-1 pathway in the development of orotic acid-induced fatty liver.Cancer risks in LKB1 germline mutation carriers.Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies The molecular chaperone Hsp90 is required for mRNA localization in Drosophila melanogaster embryos Three novel mutations of STK11 gene in Chinese patients with Peutz-Jeghers syndrome.LKB1 loss promotes endometrial cancer progression via CCL2-dependent macrophage recruitment The double edge of the HSP90-CDC37 chaperone machinery: opposing determinants of kinase stability and activity A genome-wide RNAi screen for enhancers of par mutants reveals new contributors to early embryonic polarity in Caenorhabditis elegans.Hsp90 regulates the phosphorylation and activity of serum- and glucocorticoid-regulated kinase-1.Targeting the LKB1 tumor suppressor.The LKB1 complex-AMPK pathway: the tree that hides the forest LKB1 Tumor Suppressor: Therapeutic Opportunities Knock when LKB1 Is Inactivated.Resveratrol-Induced AMP-Activated Protein Kinase Activation Is Cell-Type Dependent: Lessons from Basic Research for Clinical Application.Regulation of stability of cyclin-dependent kinase CDK11p110 and a caspase-processed form, CDK11p46, by Hsp90.Hsp90/p50cdc37 is required for mixed-lineage kinase (MLK) 3 signaling.Sti1 and Cdc37 can stabilize Hsp90 in chaperone complexes with a protein kinase.Activation of protein kinase C zeta by peroxynitrite regulates LKB1-dependent AMP-activated protein kinase in cultured endothelial cells.Molecular chaperone complexes with antagonizing activities regulate stability and activity of the tumor suppressor LKB1.

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P2860

Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability

http://www.wikidata.org/entity/Q24535623

description

2003 nî lūn-bûn

@nan

2003 թուականի Մարտին հրատարակուած գիտական յօդուած

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2003 թվականի մարտին հրատարակված գիտական հոդված

@hy

2003年の論文

@ja

2003年学术文章

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2003年学术文章

@zh-cn

2003年学术文章

@zh-hans

2003年学术文章

@zh-my

2003年学术文章

@zh-sg

2003年學術文章

@yue

name

Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability

@ast

Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability

@en

Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability

@nl

type

label

Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability

@ast

Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability

@en

Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability

@nl

prefLabel

Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability

@ast

Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability

@en

Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability

@nl

P1433

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Biochemical Journal

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Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability

@en

P2093

Margaret A Lawlor

http://www.w3.org/2001/XMLSchema#string

Nick A Morrice

http://www.w3.org/2001/XMLSchema#string

P2860

Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities

The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site

The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death

LIP1, a cytoplasmic protein functionally linked to the Peutz-Jeghers syndrome kinase LKB1

Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo

Mechanism of activation of protein kinase B by insulin and IGF-1

Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2

Phosphoinositide 3-kinase-dependent phosphorylation of the dual adaptor for phosphotyrosine and 3-phosphoinositides by the Src family of tyrosine kinase

P304

849-57

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scholarly article

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2646159

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10.1042/BJ20021813

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P433

Pt 3

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P478

370

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Jérôme Boudeau

P577

2003-03-15T00:00:00Z

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12489981

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P932

1223241

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