CCAAT/Enhancer binding proteins repress the leukemic phenotype of acute myeloid leukemia
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Repression of transcriptional activity of C/EBPalpha by E2F-dimerization partner complexesN-terminal region of CCAAT/enhancer-binding protein epsilon is critical for cell cycle arrest, apoptosis, and functional maturation during myeloid differentiationIdentification of a myeloid committed progenitor as the cancer-initiating cell in acute promyelocytic leukemia.Gain of MYC underlies recurrent trisomy of the MYC chromosome in acute promyelocytic leukemiaCEBPA point mutations in hematological malignancies.Disruption of differentiation in human cancer: AML shows the way.Human α-defensin expression is not dependent on CCAAT/enhancer binding protein-ε in a murine model.Retinoid target genes in acute promyelocytic leukemia.ATOH1 Can Regulate the Tumorigenicity of Gastric Cancer Cells by Inducing the Differentiation of Cancer Stem Cells.Direct and indirect targeting of MYC to treat acute myeloid leukemiaTranscription profiling of C/EBP targets identifies Per2 as a gene implicated in myeloid leukemiaCCAAT/enhancer binding proteins alpha and epsilon cooperate with all-trans retinoic acid in therapy but differ in their antileukemic activitiesPML-retinoic acid receptor alpha inhibits PML IV enhancement of PU.1-induced C/EBPepsilon expression in myeloid differentiation.Animal models of acute myelogenous leukaemia - development, application and future perspectives.Deficiency of CCAAT/enhancer binding protein family DNA binding prevents malignant conversion of adenoma to carcinoma in NNK-induced lung carcinogenesis in the mouseThe complex translocation (9;14;14) involving IGH and CEBPE genes suggests a new subgroup in B-lineage acute lymphoblastic leukemia.p53-Independent, normal stem cell sparing epigenetic differentiation therapy for myeloid and other malignanciesp53 independent epigenetic-differentiation treatment in xenotransplant models of acute myeloid leukemia.Transcriptional dysregulation during myeloid transformation in AML.Dysregulation of the C/EBPalpha differentiation pathway in human cancer.Runx1 deficiency permits granulocyte lineage commitment but impairs subsequent maturation.Combined staurosporine and retinoic acid induces differentiation in retinoic acid resistant acute promyelocytic leukemia cell lines.C/EBPα deregulation as a paradigm for leukemogenesis.C/EBPalpha and C/EBPvarepsilon induce the monocytic differentiation of myelomonocytic cells with the MLL-chimeric fusion gene.Increased CCAAT enhancer-binding protein epsilon (C/EBPepsilon) expression and premature apoptosis in myeloid cells expressing Gfi-1 N382S mutant associated with severe congenital neutropenia.ATRA resolves the differentiation block in t(15;17) acute myeloid leukemia by restoring PU.1 expression.Desferrioxamine induces leukemic cell differentiation potentially by hypoxia-inducible factor-1 alpha that augments transcriptional activity of CCAAT/enhancer-binding protein-alpha.Analysis of the interplay between all-trans retinoic acid and histone deacetylase inhibitors in leukemic cells.Evidence of functional interaction between NuMA-RARalpha and RXRalpha in an in vivo model of acute promyelocytic leukemia.CEBPA methylation as a prognostic biomarker in patients with de novo acute myeloid leukemia.DNA microarray expression profiling of a new t(8;13) AML case allows identification of possible leukemogenic transformation markers.Green tea polyphenol EGCG causes anti-cancerous epigenetic modulations in acute promyelocytic leukemia cells.Correlation of C/EBPα expression with response and resistance to imatinib in chronic myeloid leukaemia.
P2860
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P2860
CCAAT/Enhancer binding proteins repress the leukemic phenotype of acute myeloid leukemia
description
2003 nî lūn-bûn
@nan
2003 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
CCAAT/Enhancer binding proteins repress the leukemic phenotype of acute myeloid leukemia
@ast
CCAAT/Enhancer binding proteins repress the leukemic phenotype of acute myeloid leukemia
@en
CCAAT/Enhancer binding proteins repress the leukemic phenotype of acute myeloid leukemia
@nl
type
label
CCAAT/Enhancer binding proteins repress the leukemic phenotype of acute myeloid leukemia
@ast
CCAAT/Enhancer binding proteins repress the leukemic phenotype of acute myeloid leukemia
@en
CCAAT/Enhancer binding proteins repress the leukemic phenotype of acute myeloid leukemia
@nl
prefLabel
CCAAT/Enhancer binding proteins repress the leukemic phenotype of acute myeloid leukemia
@ast
CCAAT/Enhancer binding proteins repress the leukemic phenotype of acute myeloid leukemia
@en
CCAAT/Enhancer binding proteins repress the leukemic phenotype of acute myeloid leukemia
@nl
P2093
P1433
P1476
CCAAT/Enhancer binding proteins repress the leukemic phenotype of acute myeloid leukemia
@en
P2093
Bao-Tran H Truong
Daniel G Tenen
Danilo Perrotti
Dorothy J Park
H Phillip Koeffler
Hideaki Nakajima
Naohide Watanabe
Scott C Kogan
Tracey A Lodie
Young-Jin Lee
P304
P356
10.1182/BLOOD-2002-05-1374
P407
P577
2003-02-01T00:00:00Z