The interaction of the Bcr-Abl tyrosine kinase with the Src kinase Hck is mediated by multiple binding domains
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Kinase-independent mechanisms of resistance of leukemia stem cells to tyrosine kinase inhibitorsCurrent concepts in pediatric Philadelphia chromosome-positive acute lymphoblastic leukemiaInhibition of class II phosphoinositide 3-kinase gamma expression by p185(Bcr-Abl) contributes to impaired chemotaxis and aberrant homing of leukemic cellsEmerging drugs for chronic myeloid leukemia.Association between imatinib-resistant BCR-ABL mutation-negative leukemia and persistent activation of LYN kinase.Mechanisms of primary and secondary resistance to imatinib in chronic myeloid leukemia.Identification of Hck inhibitors as hits for the development of antileukemia and anti-HIV agents.Activation of a novel Bcr/Abl destruction pathway by WP1130 induces apoptosis of chronic myelogenous leukemia cellsLyn regulates BCR-ABL and Gab2 tyrosine phosphorylation and c-Cbl protein stability in imatinib-resistant chronic myelogenous leukemia cells.Targeting ABL and SRC kinases in chronic myeloid leukemia: experience with dasatinib.Targeted therapy of chronic myeloid leukemia.The current role of high-dose imatinib in chronic myeloid leukemia patients, newly diagnosed or resistant to standard dose.Novel virtual lead identification in the discovery of hematopoietic cell kinase (HCK) inhibitors: application of 3D QSAR and molecular dynamics simulation.The Src tyrosine kinase Hck is required for Tel-Abl- but not for Tel-Jak2-induced cell transformation.The challenge of developing robust drugs to overcome resistance.Requirement of Src kinases Lyn, Hck and Fgr for BCR-ABL1-induced B-lymphoblastic leukemia but not chronic myeloid leukemia.Src family kinases mediate cytoplasmic retention of activated STAT5 in BCR-ABL-positive cells.Activity of FB2, a novel dual Abl/Src tyrosine kinase inhibitor, against imatinib-resistant chronic myeloid leukemia in vivo and in vitro.G-protein coupled receptor 34 activates Erk and phosphatidylinositol 3-kinase/Akt pathways and functions as alternative pathway to mediate p185Bcr-Abl-induced transformation and leukemogenesis.BCR-ABL enhances the prolyl isomerase activity of Pin 1 by interacting with DAPK1 in ph+ ALL.
P2860
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P2860
The interaction of the Bcr-Abl tyrosine kinase with the Src kinase Hck is mediated by multiple binding domains
description
2003 nî lūn-bûn
@nan
2003 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
The interaction of the Bcr-Abl ...... ed by multiple binding domains
@ast
The interaction of the Bcr-Abl ...... ed by multiple binding domains
@en
The interaction of the Bcr-Abl ...... ed by multiple binding domains
@nl
type
label
The interaction of the Bcr-Abl ...... ed by multiple binding domains
@ast
The interaction of the Bcr-Abl ...... ed by multiple binding domains
@en
The interaction of the Bcr-Abl ...... ed by multiple binding domains
@nl
prefLabel
The interaction of the Bcr-Abl ...... ed by multiple binding domains
@ast
The interaction of the Bcr-Abl ...... ed by multiple binding domains
@en
The interaction of the Bcr-Abl ...... ed by multiple binding domains
@nl
P2093
P2860
P356
P1433
P1476
The interaction of the Bcr-Abl ...... ed by multiple binding domains
@en
P2093
P2860
P2888
P356
10.1038/SJ.LEU.2402778
P407
P577
2003-02-01T00:00:00Z
P5875
P6179
1046569294