MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways - Wikidata - wikimedia - TriplyDB

MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways

MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways

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CK2 phosphorylation-dependent interaction between aprataxin and MDC1 in the DNA damage response Microcephalin Is a DNA Damage Response Protein Involved in Regulation of CHK1 and BRCA1 RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly The stress kinase MRK contributes to regulation of DNA damage checkpoints through a p38gamma-independent pathway BRCA1 participates in DNA decatenation RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity Accumulation of Pax2 transactivation domain interaction protein (PTIP) at sites of DNA breaks via RNF8-dependent pathway is required for cell survival after DNA damage Regulation of Chk2 ubiquitination and signaling through autophosphorylation of serine 379 N terminus of CtIP is critical for homologous recombination-mediated double-strand break repair Regulation of TIP60 by ATF2 modulates ATM activation Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage Regulatory motifs in Chk1 DNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles' Heel of Cancer Novel Implications of DNA Damage Response in Drug Resistance of Malignant Cancers Obtained from the Functional Interaction between p53 Family and RUNX2 Acetylation of lysine 382 and phosphorylation of serine 392 in p53 modulate the interaction between p53 and MDC1 in vitro Structural mechanism of the phosphorylation-dependent dimerization of the MDC1 forkhead-associated domain The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator Dimerization, but not phosphothreonine binding, is conserved between the forkhead-associated domains of Drosophila MU2 and human MDC1 Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains Mediator of DNA damage checkpoint protein 1 regulates BRCA1 localization and phosphorylation in DNA damage checkpoint control Mutation at the polymerase active site of mouse DNA polymerase delta increases genomic instability and accelerates tumorigenesis The DNA damage response mediator MDC1 directly interacts with the anaphase-promoting complex/cyclosome BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage MDC1 regulates DNA-PK autophosphorylation in response to DNA damage Cell-cycle checkpoints and cancer HCLK2 is essential for the mammalian S-phase checkpoint and impacts on Chk1 stability Phospho-Ser/Thr-binding domains: navigating the cell cycle and DNA damage response NFBD1/MDC1 associates with p53 and regulates its function at the crossroad between cell survival and death in response to DNA damage A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage Giraffe genome sequence reveals clues to its unique morphology and physiology.Double strand break repair functions of histone H2AX BRCT domains: A little more than kin, and less than kind Xenopus Cds1 is regulated by DNA-dependent protein kinase and ATR during the cell cycle checkpoint response to double-stranded DNA ends Site-specific phosphorylation of the DNA damage response mediator rad9 by cyclin-dependent kinases regulates activation of checkpoint kinase 1 BLM helicase-dependent and -independent roles of 53BP1 during replication stress-mediated homologous recombination.Differential regulation of centrosome integrity by DNA damage response proteins.Phosphorylation of nucleotide excision repair factor xeroderma pigmentosum group A by ataxia telangiectasia mutated and Rad3-related-dependent checkpoint pathway promotes cell survival in response to UV irradiation.BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer

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MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways

http://www.wikidata.org/entity/Q28212514

description

2003 nî lūn-bûn

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2003 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2003年の論文

@ja

2003年論文

@yue

2003年論文

@zh-hant

2003年論文

@zh-hk

2003年論文

@zh-mo

2003年論文

@zh-tw

2003年论文

@wuu

name

MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways

@ast

MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways

@en

MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways

@nl

type

label

MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways

@ast

MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways

@en

MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways

@nl

prefLabel

MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways

@ast

MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways

@en

MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways

@nl

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MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways

@en

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Junjie Chen

http://www.w3.org/2001/XMLSchema#string

Katherine Minter-Dykhouse

http://www.w3.org/2001/XMLSchema#string

Xianglin Wu

http://www.w3.org/2001/XMLSchema#string

Zhenkun Lou

http://www.w3.org/2001/XMLSchema#string

P2860

Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

Megabase chromatin domains involved in DNA double-strand breaks in vivo

II. Structure and specificity of the interaction between the FHA2 domain of Rad53 and phosphotyrosyl peptides

The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint.

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway

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10.1038/NATURE01447

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421

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1052973885

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