PAC-1 activates procaspase-3 in vitro through relief of zinc-mediated inhibition - Wikidata - wikimedia - TriplyDB

PAC-1 activates procaspase-3 in vitro through relief of zinc-mediated inhibition

PAC-1 activates procaspase-3 in vitro through relief of zinc-mediated inhibition

http://www.wikidata.org/entity/Q28237935

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Intrinsic-mediated caspase activation is essential for cardiomyocyte hypertrophy Targeting the apoptosis pathway in hematologic malignancies A designed redox-controlled caspase Zinc-mediated Allosteric Inhibition of Caspase-6 Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation Procaspase-3 activation as an anti-cancer strategy: structure-activity relationship of procaspase-activating compound 1 (PAC-1) and its cellular co-localization with caspase-3 Pharmacokinetics and derivation of an anticancer dosing regimen for PAC-1, a preferential small molecule activator of procaspase-3, in healthy dogs Discovery and canine preclinical assessment of a nontoxic procaspase-3-activating compound Dual small-molecule targeting of procaspase-3 dramatically enhances zymogen activation and anticancer activity Small-Molecule Procaspase-3 Activation Sensitizes Cancer to Treatment with Diverse Chemotherapeutics Zinc-binding cysteines: diverse functions and structural motifs.The effect of zinc and the role of p53 in copper-induced cellular stress responses.ERO1α-dependent endoplasmic reticulum-mitochondrial calcium flux contributes to ER stress and mitochondrial permeabilization by procaspase-activating compound-1 (PAC-1).Small-molecule activators of a proenzyme.Allosteric regulation of protease activity by small molecules.The potential for caspases in drug discovery Folate deficiency provides protection against colon carcinogenesis in DNA polymerase beta haploinsufficient mice Elevated zinc induces endothelial apoptosis via disruption of glutathione metabolism: role of the ADP translocator.Parallel synthesis and biological evaluation of 837 analogues of procaspase-activating compound 1 (PAC-1)Preparation of the caspase-3/7 substrate Ac-DEVD-pNA by solution-phase peptide synthesis Zinc in innate and adaptive tumor immunity.Expression of executioner procaspases and their activation by a procaspase-activating compound in chronic lymphocytic leukemia cells A multipronged approach for compiling a global map of allosteric regulation in the apoptotic caspases.Ablation of SGK1 impairs endothelial cell migration and tube formation leading to decreased neo-angiogenesis following myocardial infarction The bioinorganic chemistry of apoptosis: potential inhibitory zinc binding sites in caspase-3.Identification of new snake venom metalloproteinase inhibitors using compound screening and rational Peptide design Turning on caspases with genetics and small molecules Removal of Metabolic Liabilities Enables Development of Derivatives of Procaspase-Activating Compound 1 (PAC-1) with Improved Pharmacokinetics Derivatives of Procaspase-Activating Compound 1 (PAC-1) and their Anticancer Activities.Differential effects of procaspase-3 activating compounds in the induction of cancer cell death.Targeting procaspase-3 with WF-208, a novel PAC-1 derivative, causes selective cancer cell apoptosis Fibrils colocalize caspase-3 with procaspase-3 to foster maturation.Molecular evidence of Zn chelation of the procaspase activating compound B-PAC-1 in B cell lymphoma.A novel reporter system for molecular imaging and high-throughput screening of anticancer drugs.Death by caspase dimerization.Small molecules as pro-apoptotic anticancer agents.Essential requirement of cytochrome c release for caspase activation by procaspase-activating compound defined by cellular models.SM-1, a novel PAC-1 derivative, activates procaspase-3 and causes cancer cell apoptosis.The Combination of Vemurafenib and Procaspase-3 Activation Is Synergistic in Mutant BRAF Melanomas.Synergistic antitumor activity of pro-apoptotic agent PAC-1 with cisplatinum by the activation of CASP3 in pulmonary adenocarcinoma cell line H1299.

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P2860

PAC-1 activates procaspase-3 in vitro through relief of zinc-mediated inhibition

http://www.wikidata.org/entity/Q28237935

description

2009 nî lūn-bûn

@nan

2009 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

2009年の論文

@ja

2009年論文

@yue

2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

@zh-mo

2009年論文

@zh-tw

2009年论文

@wuu

name

PAC-1 activates procaspase-3 in vitro through relief of zinc-mediated inhibition

@ast

PAC-1 activates procaspase-3 in vitro through relief of zinc-mediated inhibition

@en

PAC-1 activates procaspase-3 in vitro through relief of zinc-mediated inhibition

@nl

type

label

PAC-1 activates procaspase-3 in vitro through relief of zinc-mediated inhibition

@ast

PAC-1 activates procaspase-3 in vitro through relief of zinc-mediated inhibition

@en

PAC-1 activates procaspase-3 in vitro through relief of zinc-mediated inhibition

@nl

prefLabel

PAC-1 activates procaspase-3 in vitro through relief of zinc-mediated inhibition

@ast

PAC-1 activates procaspase-3 in vitro through relief of zinc-mediated inhibition

@en

PAC-1 activates procaspase-3 in vitro through relief of zinc-mediated inhibition

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J.JMB.2009.03.003

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Journal of Molecular Biology

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PAC-1 activates procaspase-3 in vitro through relief of zinc-mediated inhibition

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Diana C West

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Joy J Y Lee

http://www.w3.org/2001/XMLSchema#string

Kara N Ramsey

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Paul J Hergenrother

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P2860

The Hallmarks of Cancer

Mechanism of XIAP-mediated inhibition of caspase-9

In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains

Identification and characterization of CPP32/Mch2 homolog 1, a novel cysteine protease similar to CPP32

Pharmacological manipulation of cell death: clinical applications in sight?

Engineering a dimeric caspase-9: a re-evaluation of the induced proximity model for caspase activation

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

Death and anti-death: tumour resistance to apoptosis

Zinc is a potent inhibitor of the apoptotic protease, caspase-3. A novel target for zinc in the inhibition of apoptosis

Biochemical characteristics of caspases-3, -6, -7, and -8

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144-158

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10.1016/J.JMB.2009.03.003

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1

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388

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Quinn P Peterson

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19281821

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2714579

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