Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers
about
Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth controlTAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathwayThe hippo signaling pathway in development and cancerIdentification and validation of oncogenes in liver cancer using an integrative oncogenomic approachA positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidizationThe two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatmentHippo/YAP pathway for targeted therapyThe Hippo-YAP pathway in organ size control and tumorigenesis: an updated versionMerlin, a "magic" linker between extracellular cues and intracellular signaling pathways that regulate cell motility, proliferation, and survivalhNaa10p contributes to tumorigenesis by facilitating DNMT1-mediated tumor suppressor gene silencingA crucial role of WW45 in developing epithelial tissues in the mouseThe Hippo Pathway Targets Rae1 to Regulate Mitosis and Organ Size and to Feed Back to Regulate Upstream Components Merlin, Hippo, and WartsCrucial role for Mst1 and Mst2 kinases in early embryonic development of the mouseCharacterization and evolution of the cell cycle-associated mob domain-containing proteins in eukaryotesSalvador-Warts-Hippo pathway in a developmental checkpoint monitoring helix-loop-helix proteins.The Hippo signaling pathway in stem cell biology and cancerThe role of the Hippo pathway in human disease and tumorigenesisLATS1/WARTS phosphorylates MYPT1 to counteract PLK1 and regulate mammalian mitotic progressionCharacterization of the p53 response to oncogene-induced senescence.Context-dependent requirement for dE2F during oncogenic proliferationLATS2 is de-methylated and overexpressed in nasopharyngeal carcinoma and predicts poor prognosis.CD44 attenuates activation of the hippo signaling pathway and is a prime therapeutic target for glioblastomaEpigenome remodelling in breast cancer: insights from an early in vitro model of carcinogenesisExpression of hippo pathway in colorectal cancer.Frequent and simultaneous epigenetic inactivation of TP53 pathway genes in acute lymphoblastic leukemiaStability of the LATS2 tumor suppressor gene is regulated by tristetraprolinThe mitosis-to-interphase transition is coordinated by cross talk between the SIN and MOR pathways in Schizosaccharomyces pombe.Identification of driver and passenger DNA methylation in cancer by epigenomic analysis.Down-regulation of Yes Associated Protein 1 expression reduces cell proliferation and clonogenicity of pancreatic cancer cells.The Lats2 tumor suppressor augments p53-mediated apoptosis by promoting the nuclear proapoptotic function of ASPP1Heat shock protein 90 inhibition depletes LATS1 and LATS2, two regulators of the mammalian hippo tumor suppressor pathway.LATS2 suppresses oncogenic Wnt signaling by disrupting β-catenin/BCL9 interaction.NDR kinases regulate essential cell processes from yeast to humans.KIBRA regulates Hippo signaling activity via interactions with large tumor suppressor kinases.WWP1 E3 ligase targets LATS1 for ubiquitin-mediated degradation in breast cancer cells.Itch E3 ubiquitin ligase regulates large tumor suppressor 1 stability [corrected]Identification of a tumor suppressor relay between the FOXP3 and the Hippo pathways in breast and prostate cancers.New genetic variants of LATS1 detected in urinary bladder and colon cancer.YAP, TAZ, and Yorkie: a conserved family of signal-responsive transcriptional coregulators in animal development and human disease.Lats2 modulates adipocyte proliferation and differentiation via hippo signaling.
P2860
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P2860
Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers
description
2005 nî lūn-bûn
@nan
2005 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Down-regulation of LATS1 and L ...... notype in human breast cancers
@ast
Down-regulation of LATS1 and L ...... notype in human breast cancers
@en
Down-regulation of LATS1 and L ...... notype in human breast cancers
@nl
type
label
Down-regulation of LATS1 and L ...... notype in human breast cancers
@ast
Down-regulation of LATS1 and L ...... notype in human breast cancers
@en
Down-regulation of LATS1 and L ...... notype in human breast cancers
@nl
prefLabel
Down-regulation of LATS1 and L ...... notype in human breast cancers
@ast
Down-regulation of LATS1 and L ...... notype in human breast cancers
@en
Down-regulation of LATS1 and L ...... notype in human breast cancers
@nl
P2093
P3181
P1476
Down-regulation of LATS1 and L ...... notype in human breast cancers
@en
P2093
Chie Takahata
Natsumi Irahara
Shinzaburo Noguchi
Tetsuya Taguchi
Yasuhiro Tamaki
Yasuo Miyoshi
Yuri Takahashi
P304
P3181
P356
10.1158/1078-0432.CCR-04-1773
P407
P577
2005-02-15T00:00:00Z