Cbfa1/RUNX2 directs specific expression of the sclerosteosis gene (SOST)
about
Sost down-regulation by mechanical strain in human osteoblastic cells involves PGE2 signaling via EP4Polymorphisms in the sclerosteosis/van Buchem disease gene (SOST) region are associated with bone-mineral density in elderly whites.Distinct modes of inhibition by sclerostin on bone morphogenetic protein and Wnt signaling pathwaysFunctional relevance of the BMD-associated polymorphism rs312009: novel involvement of RUNX2 in LRP5 transcriptional regulationFrom estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosisLoad regulates bone formation and Sclerostin expression through a TGFβ-dependent mechanismSp1/Sp3 and DNA-methylation contribute to basal transcriptional activation of human podoplanin in MG63 versus Saos-2 osteoblastic cellsIdentification of a new pebp2alphaA2 isoform from zebrafish runx2 capable of inducing osteocalcin gene expression in vitro.Developments in sclerostin biology: regulation of gene expression, mechanisms of action, and physiological functions.Interactions of sclerostin with FGF23, soluble klotho and vitamin D in renal transplantationSclerostin: current knowledge and future perspectives.Multi-walled carbon nanotubes promote cementoblast differentiation and mineralization through the TGF-β/Smad signaling pathway.Metastatic breast cancer cells inhibit osteoblast differentiation through the Runx2/CBFβ-dependent expression of the Wnt antagonist, sclerostin.The Wnt Inhibitor Sclerostin Is Up-regulated by Mechanical Unloading in Osteocytes in Vitro.Do epigenetic marks govern bone mass and homeostasis?Estrogen receptor α mediates proliferation of osteoblastic cells stimulated by estrogen and mechanical strain, but their acute down-regulation of the Wnt antagonist Sost is mediated by estrogen receptor β.Expression of serum amyloid A transcripts in human bone tissues, differentiated osteoblast-like stem cells and human osteosarcoma cell lines.Cell culture systems for studies of bone and tooth mineralization.Sclerostin's role in bone's adaptive response to mechanical loading.Investigational anabolic therapies for osteoporosis.Wnt proteins in mineralized tissue development and homeostasis.Sclerostin: a possible target for the management of cancer-induced bone disease.SaOS2 Osteosarcoma cells as an in vitro model for studying the transition of human osteoblasts to osteocytes.A Sclerostin super-producer cell line derived from the human cell line SaOS-2: a new tool for the study of the molecular mechanisms driving Sclerostin expression.The post-translational phenotype of collagen synthesized by SAOS-2 osteosarcoma cells.ERβ compensates for the absence of ERα function to promote osteoblast viability by inhibition of SOST signaling.DNA methylation contributes to the regulation of sclerostin expression in human osteocytes.Sclerostin expression and functions beyond the osteocyte.Osterix and RUNX2 are Transcriptional Regulators of Sclerostin in Human Bone.Methylation of BoneSOST, Its mRNA, and Serum Sclerostin Levels Correlate Strongly With Fracture Risk in Postmenopausal WomenPrior administration of vitamin K2 improves the therapeutic effects of zoledronic acid in ovariectomized rats by antagonizing zoledronic acid-induced inhibition of osteoblasts proliferation and mineralization
P2860
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P2860
Cbfa1/RUNX2 directs specific expression of the sclerosteosis gene (SOST)
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2004 nî lūn-bûn
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2004 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2004 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2004年の論文
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2004年論文
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2004年論文
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2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
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2004年论文
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Cbfa1/RUNX2 directs specific expression of the sclerosteosis gene (SOST)
@ast
Cbfa1/RUNX2 directs specific expression of the sclerosteosis gene (SOST)
@en
Cbfa1/RUNX2 directs specific expression of the sclerosteosis gene (SOST)
@nl
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label
Cbfa1/RUNX2 directs specific expression of the sclerosteosis gene (SOST)
@ast
Cbfa1/RUNX2 directs specific expression of the sclerosteosis gene (SOST)
@en
Cbfa1/RUNX2 directs specific expression of the sclerosteosis gene (SOST)
@nl
prefLabel
Cbfa1/RUNX2 directs specific expression of the sclerosteosis gene (SOST)
@ast
Cbfa1/RUNX2 directs specific expression of the sclerosteosis gene (SOST)
@en
Cbfa1/RUNX2 directs specific expression of the sclerosteosis gene (SOST)
@nl
P2093
P2860
P356
P1476
Cbfa1/RUNX2 directs specific expression of the sclerosteosis gene (SOST)
@en
P2093
Brad Sevetson
Scott Taylor
P2860
P304
P356
10.1074/JBC.M306249200
P407
P577
2004-04-02T00:00:00Z