Sost down-regulation by mechanical strain in human osteoblastic cells involves PGE2 signaling via EP4
about
E-type prostanoid receptor 4 (EP4) in disease and therapyDifferential mechanisms of de-regulated bone formation in rheumatoid arthritis and spondyloarthritisLoad regulates bone formation and Sclerostin expression through a TGFβ-dependent mechanismDevelopments in sclerostin biology: regulation of gene expression, mechanisms of action, and physiological functions.Protein kinase Cα (PKCα) regulates bone architecture and osteoblast activity.Osteocyte expression of caspase-3, COX-2, IL-6 and sclerostin are spatially and temporally associated following stress fracture initiation.Update on ankylosing spondylitis: current concepts in pathogenesis.Planar cell polarity aligns osteoblast division in response to substrate strainIncreased sclerostin levels after further ablation of remnant estrogen by aromatase inhibitors.In vivo mechanical loading rapidly activates β-catenin signaling in osteocytes through a prostaglandin mediated mechanism.Transient Effect of 17β-estradiol on Osteoporosis in Ovariectomized Rats Accompanied with Unilateral Disuse in the Early PhaseLoading-related regulation of transcription factor EGR2/Krox-20 in bone cells is ERK1/2 protein-mediated and prostaglandin, Wnt signaling pathway-, and insulin-like growth factor-I axis-dependentThe Wnt Inhibitor Sclerostin Is Up-regulated by Mechanical Unloading in Osteocytes in Vitro.Preclinical models for in vitro mechanical loading of bone-derived cells.A specific role for phosphoinositide 3-kinase and AKT in osteoblasts?Bone and skeletal muscle: Key players in mechanotransduction and potential overlapping mechanisms.The cyclooxygenase-2 selective inhibitor NS-398 does not influence trabecular or cortical bone gain resulting from repeated mechanical loading in female miceEstrogen receptor-α is required for the osteogenic response to mechanical loading in a ligand-independent manner involving its activation function 1 but not 2.PUFAs, Bone Mineral Density, and Fragility Fracture: Findings from Human StudiesEstrogen receptor α mediates proliferation of osteoblastic cells stimulated by estrogen and mechanical strain, but their acute down-regulation of the Wnt antagonist Sost is mediated by estrogen receptor β.Old age and the associated impairment of bones' adaptation to loading are associated with transcriptomic changes in cellular metabolism, cell-matrix interactions and the cell cycle.Mechanical motion promotes expression of Prg4 in articular cartilage via multiple CREB-dependent, fluid flow shear stress-induced signaling pathways.Sclerostin's role in bone's adaptive response to mechanical loading.Toward mechanical systems biology in bone.Is interaction between age-dependent decline in mechanical stimulation and osteocyte-estrogen receptor levels the culprit for postmenopausal-impaired bone formation?Osteoimmunology and bone homeostasis: relevance to spondyloarthritis.Osteocyte control of bone remodeling: is sclerostin a key molecular coordinator of the balanced bone resorption-formation cycles?Role and mechanism of action of sclerostin in bone.SaOS2 Osteosarcoma cells as an in vitro model for studying the transition of human osteoblasts to osteocytes.A Sclerostin super-producer cell line derived from the human cell line SaOS-2: a new tool for the study of the molecular mechanisms driving Sclerostin expression.Nitric oxide is involved in the down-regulation of SOST expression induced by mechanical loading.The regulation of cytotoxicity and cyclooxygenase-2 expression by 2-hydroxy-ethyl methacrylate in human osteoblasts are related to intracellular glutathione levels.Exploiting the WNT Signaling Pathway for Clinical Purposes.A threshold of mechanical strain intensity for the direct activation of osteoblast function exists in a murine maxilla loading model.Early response of bone marrow osteoprogenitors to skeletal unloading and sclerostin antibody.SOST, an LNGFR target, inhibits the osteogenic differentiation of rat ectomesenchymal stem cells.Epithelial Cells Secrete Interferon-γ Which Suppresses Expression of Receptor Activator of Nuclear Factor Kappa-B Ligand in Human Mandibular Osteoblast-Like Cells.
P2860
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P2860
Sost down-regulation by mechanical strain in human osteoblastic cells involves PGE2 signaling via EP4
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2011 nî lūn-bûn
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2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի օգոստոսին հրատարակված գիտական հոդված
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2011年の論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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2011年论文
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name
Sost down-regulation by mechan ...... nvolves PGE2 signaling via EP4
@ast
Sost down-regulation by mechan ...... nvolves PGE2 signaling via EP4
@en
Sost down-regulation by mechan ...... nvolves PGE2 signaling via EP4
@en-gb
Sost down-regulation by mechan ...... nvolves PGE2 signaling via EP4
@nl
type
label
Sost down-regulation by mechan ...... nvolves PGE2 signaling via EP4
@ast
Sost down-regulation by mechan ...... nvolves PGE2 signaling via EP4
@en
Sost down-regulation by mechan ...... nvolves PGE2 signaling via EP4
@en-gb
Sost down-regulation by mechan ...... nvolves PGE2 signaling via EP4
@nl
prefLabel
Sost down-regulation by mechan ...... nvolves PGE2 signaling via EP4
@ast
Sost down-regulation by mechan ...... nvolves PGE2 signaling via EP4
@en
Sost down-regulation by mechan ...... nvolves PGE2 signaling via EP4
@en-gb
Sost down-regulation by mechan ...... nvolves PGE2 signaling via EP4
@nl
P2093
P2860
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Sost down-regulation by mechan ...... nvolves PGE2 signaling via EP4
@en
P2093
Andrew Sunters
Joanna S Price
Lance E Lanyon
P2860
P304
P356
10.1016/J.FEBSLET.2011.06.019
P407
P577
2011-08-04T00:00:00Z