TLS/FUS fusion domain of TLS/FUS-erg chimeric protein resulting from the t(16;21) chromosomal translocation in human myeloid leukemia functions as a transcriptional activation domain
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EWS/FLI mediates transcriptional repression via NKX2.2 during oncogenic transformation in Ewing's sarcomaTLS/FUS, a pro-oncogene involved in multiple chromosomal translocations, is a novel regulator of BCR/ABL-mediated leukemogenesis.TLS-ERG leukemia fusion protein inhibits RNA splicing mediated by serine-arginine proteinshTAF(II)68, a novel RNA/ssDNA-binding protein with homology to the pro-oncoproteins TLS/FUS and EWS is associated with both TFIID and RNA polymerase IIA new subtype of frontotemporal lobar degeneration with FUS pathologyRetroviral transduction of TLS-ERG initiates a leukemogenic program in normal human hematopoietic cellsRGG-boxes of the EWS oncoprotein repress a range of transcriptional activation domainsThe Ews-ERG fusion protein can initiate neoplasia from lineage-committed haematopoietic cells.Mechanisms of FUS mutations in familial amyotrophic lateral sclerosisFunctions of heterogeneous nuclear ribonucleoproteins in stem cell potency and differentiationEbp1 sumoylation, regulated by TLS/FUS E3 ligase, is required for its anti-proliferative activity.FUS-DDIT3 prevents the development of adipocytic precursors in liposarcoma by repressing PPARgamma and C/EBPalpha and activating eIF4E.The oncogenic TLS-ERG fusion protein exerts different effects in hematopoietic cells and fibroblasts.A domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the TEL-PDGFR beta oncoprotein.Dual transforming activities of the FUS (TLS)-ERG leukemia fusion protein conferred by two N-terminal domains of FUS (TLS).Fus gene mutations in familial and sporadic amyotrophic lateral sclerosis.Knockdown of the Drosophila fused in sarcoma (FUS) homologue causes deficient locomotive behavior and shortening of motoneuron terminal branches.Nuclear localization sequence of FUS and induction of stress granules by ALS mutants.The effect of PRMT1-mediated arginine methylation on the subcellular localization, stress granules, and detergent-insoluble aggregates of FUS/TLS.Male sterility and enhanced radiation sensitivity in TLS(-/-) mice.Self-assembled FUS binds active chromatin and regulates gene transcription.The RNA-binding protein fused in sarcoma (FUS) functions downstream of poly(ADP-ribose) polymerase (PARP) in response to DNA damageA comparative clinical, pathological, biochemical and genetic study of fused in sarcoma proteinopathiesFUS/TLS contributes to replication-dependent histone gene expression by interaction with U7 snRNPs and histone-specific transcription factorsOncogenic transformation and inhibition of adipocytic conversion of preadipocytes by TLS/FUS-CHOP type II chimeric protein.The RRM domain of human fused in sarcoma protein reveals a non-canonical nucleic acid binding site.Expression of human FUS protein in Drosophila leads to progressive neurodegenerationFUS-linked essential tremor associated with motor dysfunction in Drosophila.The multifunctional protein fused in sarcoma (FUS) is a coactivator of microphthalmia-associated transcription factor (MITF).Deregulation of DUX4 and ERG in acute lymphoblastic leukemia.FUsed in sarcoma is a novel regulator of manganese superoxide dismutase gene transcription.TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration.The complexity of NF-κB signaling in inflammation and cancer.Ets Related Gene and Smad3 Proteins Collaborate to Activate Transforming Growth Factor-Beta Mediated Signaling Pathway in ETS Related Gene-Positive Prostate Cancer Cells.Molecular Mechanism of Activation of Transforming Growth Factor Beta/Smads Signaling Pathway in Ets Related Gene-Positive Prostate Cancers.Anti-Epileptic Drug Targets Ewing Sarcoma.Histone deacetylase inhibitors, valproic acid and trichostatin-A induce apoptosis and affect acetylation status of p53 in ERG-positive prostate cancer cells.Progress in the molecular biology of ewing tumors.The oncofusion protein FUS-ERG targets key hematopoietic regulators and modulates the all-trans retinoic acid signaling pathway in t(16;21) acute myeloid leukemia.TDP-43/FUS in motor neuron disease: Complexity and challenges.
P2860
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P2860
TLS/FUS fusion domain of TLS/FUS-erg chimeric protein resulting from the t(16;21) chromosomal translocation in human myeloid leukemia functions as a transcriptional activation domain
description
1994 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1994
@ast
im Dezember 1994 veröffentlichter wissenschaftlicher Artikel
@de
scientific article (publication date: December 1994)
@en
vedecký článok (publikovaný 1994-12)
@sk
vědecký článek publikovaný v roce 1994
@cs
wetenschappelijk artikel (gepubliceerd in 1994-12)
@nl
наукова стаття, опублікована в грудні 1994
@uk
научни чланак (објављен 1994-12)
@sr
name
TLS/FUS fusion domain of TLS/F ...... nscriptional activation domain
@ast
TLS/FUS fusion domain of TLS/F ...... nscriptional activation domain
@en
TLS/FUS fusion domain of TLS/F ...... nscriptional activation domain
@nl
type
label
TLS/FUS fusion domain of TLS/F ...... nscriptional activation domain
@ast
TLS/FUS fusion domain of TLS/F ...... nscriptional activation domain
@en
TLS/FUS fusion domain of TLS/F ...... nscriptional activation domain
@nl
prefLabel
TLS/FUS fusion domain of TLS/F ...... nscriptional activation domain
@ast
TLS/FUS fusion domain of TLS/F ...... nscriptional activation domain
@en
TLS/FUS fusion domain of TLS/F ...... nscriptional activation domain
@nl
P2093
P3181
P1433
P1476
TLS/FUS fusion domain of TLS/F ...... nscriptional activation domain
@en
P2093
P304
P3181
P407
P577
1994-12-01T00:00:00Z