Retroviral transduction of TLS-ERG initiates a leukemogenic program in normal human hematopoietic cells
about
TLS-ERG leukemia fusion protein inhibits RNA splicing mediated by serine-arginine proteinsThe oncogenic role of the ETS transcription factors MEF and ERGDirecting oncogenic fusion genes into stem cells via an SCL enhancer.The oncogenic TLS-ERG fusion protein exerts different effects in hematopoietic cells and fibroblasts.Dual transforming activities of the FUS (TLS)-ERG leukemia fusion protein conferred by two N-terminal domains of FUS (TLS).Dissociation of telomerase activity and telomere length maintenance in primitive human hematopoietic cells.ERG deregulation induces PIM1 over-expression and aneuploidy in prostate epithelial cells.Frameshift and novel mutations in FUS in familial amyotrophic lateral sclerosis and ALS/dementiaPrimitive origins of prostate cancer: in vivo evidence for prostate-regenerating cells and prostate cancer-initiating cellsBreast cancer stem cells revealed.Expression of TEL-JAK2 in primary human hematopoietic cells drives erythropoietin-independent erythropoiesis and induces myelofibrosis in vivoPromiscuous partnerships in Ewing's sarcoma.Concepts of human leukemic development.Cancer stem cells in nervous system tumors.Hematopoietic cell fate and the initiation of leukemic properties in primitive primary human cells are influenced by Ras activity and farnesyltransferase inhibitionTransposon mutagenesis reveals cooperation of ETS family transcription factors with signaling pathways in erythro-megakaryocytic leukemiaETS family transcription factors collaborate with alternative signaling pathways to induce carcinoma from adult murine prostate cells.Cryptic FUS-ERG fusion identified by RNA-sequencing in childhood acute myeloid leukemia.RNA-binding proteins as molecular links between cancer and neurodegeneration.FUS expression alters the differentiation response to all-trans retinoic acid in NB4 and NB4R2 cells.Persistent transactivation by meis1 replaces hox function in myeloid leukemogenesis models: evidence for co-occupancy of meis1-pbx and hox-pbx complexes on promoters of leukemia-associated genes.Relapse of Acute Myeloid Leukemia with t(16;21)(p11;q22) Mimicking Autoimmune Pancreatitis after Second Allogeneic Bone Marrow TransplantationmiRNA-regulated cancer stem cells: understanding the property and the role of miRNA in carcinogenesis.Regulation of Stem Cell Self-Renewal and Oncogenesis by RNA-Binding Proteins.The oncofusion protein FUS-ERG targets key hematopoietic regulators and modulates the all-trans retinoic acid signaling pathway in t(16;21) acute myeloid leukemia.Direct evidence for cooperating genetic events in the leukemic transformation of normal human hematopoietic cells.Overexpression of ERG in cord blood progenitors promotes expansion and recapitulates molecular signatures of high ERG leukemias.Model systems for examining effects of leukemia-associated oncogenes in primary human CD34+ cells via retroviral transduction.Distinct classes of human stem cells that differ in proliferative and self-renewal potential.Acute basophilic leukemia associated with the t(16;21)(p11;q22)/FUS-ERG fusion gene.Fus deficiency in mice results in defective B-lymphocyte development and activation, high levels of chromosomal instability and perinatal death.
P2860
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P2860
Retroviral transduction of TLS-ERG initiates a leukemogenic program in normal human hematopoietic cells
description
1998 nî lūn-bûn
@nan
1998 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Retroviral transduction of TLS ...... rmal human hematopoietic cells
@ast
Retroviral transduction of TLS ...... rmal human hematopoietic cells
@en
Retroviral transduction of TLS ...... rmal human hematopoietic cells
@nl
type
label
Retroviral transduction of TLS ...... rmal human hematopoietic cells
@ast
Retroviral transduction of TLS ...... rmal human hematopoietic cells
@en
Retroviral transduction of TLS ...... rmal human hematopoietic cells
@nl
prefLabel
Retroviral transduction of TLS ...... rmal human hematopoietic cells
@ast
Retroviral transduction of TLS ...... rmal human hematopoietic cells
@en
Retroviral transduction of TLS ...... rmal human hematopoietic cells
@nl
P2093
P2860
P356
P1476
Retroviral transduction of TLS ...... rmal human hematopoietic cells
@en
P2093
D S Pereira
P2860
P304
P356
10.1073/PNAS.95.14.8239
P407
P577
1998-07-07T00:00:00Z