PAK4 mediates morphological changes through the regulation of GEF-H1
about
The emerging importance of group II PAKsGroup I and II mammalian PAKs have different modes of activation by Cdc42GTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivoTargeting and transport: how microtubules control focal adhesion dynamicsMolecular mechanisms controlling vascular lumen formation in three-dimensional extracellular matricesThe role of p21-activated kinases in hepatocellular carcinoma metastasisRho GTPases in collective cell migrationCdc42 and k-Ras Control Endothelial Tubulogenesis through Apical Membrane and Cytoskeletal Polarization: Novel Stimulatory Roles for GTPase Effectors, the Small GTPases, Rac2 and Rap1b, and Inhibitory Influence of Arhgap31 and Rasa1Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growthType II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrateSignaling, Regulation, and Specificity of the Type II p21-activated KinasesPak4, a novel Gab1 binding partner, modulates cell migration and invasion by the Met receptorPAK thread from amoeba to mammalsPAK as a therapeutic target in gastric cancerGL-1196 Suppresses the Proliferation and Invasion of Gastric Cancer Cells via Targeting PAK4 and Inhibiting PAK4-Mediated Signaling PathwaysPAK4: a pluripotent kinase that regulates prostate cancer cell adhesion.p21-activated kinase 4 phosphorylation of integrin beta5 Ser-759 and Ser-762 regulates cell migrationPAK4 kinase-mediated SCG10 phosphorylation involved in gastric cancer metastasisInteraction of PDZRhoGEF with microtubule-associated protein 1 light chains: link between microtubules, actin cytoskeleton, and neuronal polarityEpithelial junctions and Rho family GTPases: the zonular signalosome.The RhoA activator GEF-H1/Lfc is a transforming growth factor-beta target gene and effector that regulates alpha-smooth muscle actin expression and cell migrationGEF-H1 couples nocodazole-induced microtubule disassembly to cell contractility via RhoA.Central role of the exchange factor GEF-H1 in TNF-α-induced sequential activation of Rac, ADAM17/TACE, and RhoA in tubular epithelial cells.EB1, p150Glued, and Clasp1 control endothelial tubulogenesis through microtubule assembly, acetylation, and apical polarizationFAM123A binds to microtubules and inhibits the guanine nucleotide exchange factor ARHGEF2 to decrease actomyosin contractility.PAK4 interacts with p85 alpha: implications for pancreatic cancer cell migrationActivated-PAK4 predicts worse prognosis in breast cancer and promotes tumorigenesis through activation of PI3K/AKT signaling.Homozygous ARHGEF2 mutation causes intellectual disability and midbrain-hindbrain malformation.LC-0882 targets PAK4 and inhibits PAK4-related signaling pathways to suppress the proliferation and invasion of gastric cancer cells.Mechanotransduction by GEF-H1 as a novel mechanism of ventilator-induced vascular endothelial permeability.Maternal pak4 expression is required for primitive myelopoiesis in zebrafishSimultaneous and independent tuning of RhoA and Rac1 activity with orthogonally inducible promoters.Integrin-mediated cell attachment induces a PAK4-dependent feedback loop regulating cell adhesion through modified integrin alpha v beta 5 clustering and turnover.Characterization of SPAK and OSR1, regulatory kinases of the Na-K-2Cl cotransporter.A transcriptional cross-talk between RhoA and c-Myc inhibits the RhoA/Rock-dependent cytoskeleton.Interaction between the type III effector VopO and GEF-H1 activates the RhoA-ROCK pathway.Altered prefrontal cortical MARCKS and PPP1R9A mRNA expression in schizophrenia and bipolar disorder.P21-activated kinase 4 overexpression in metastatic gastric cancer patientsThe Cdc42 Effector Kinase PAK4 Localizes to Cell-Cell Junctions and Contributes to Establishing Cell Polarity.Rac signaling in breast cancer: a tale of GEFs and GAPs.
P2860
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P2860
PAK4 mediates morphological changes through the regulation of GEF-H1
description
2005 nî lūn-bûn
@nan
2005 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
PAK4 mediates morphological changes through the regulation of GEF-H1
@ast
PAK4 mediates morphological changes through the regulation of GEF-H1
@en
PAK4 mediates morphological changes through the regulation of GEF-H1
@nl
type
label
PAK4 mediates morphological changes through the regulation of GEF-H1
@ast
PAK4 mediates morphological changes through the regulation of GEF-H1
@en
PAK4 mediates morphological changes through the regulation of GEF-H1
@nl
prefLabel
PAK4 mediates morphological changes through the regulation of GEF-H1
@ast
PAK4 mediates morphological changes through the regulation of GEF-H1
@en
PAK4 mediates morphological changes through the regulation of GEF-H1
@nl
P2093
P3181
P356
P1476
PAK4 mediates morphological changes through the regulation of GEF-H1
@en
P2093
Bahija Jallal
Marinella G Callow
Mikhail L Gishizky
P304
P3181
P356
10.1242/JCS.02313
P407
P577
2005-04-12T00:00:00Z