Deficiency of ADAP/Fyb/SLAP-130 destabilizes SKAP55 in Jurkat T cells - Wikidata - wikimedia - TriplyDB

Deficiency of ADAP/Fyb/SLAP-130 destabilizes SKAP55 in Jurkat T cells

Deficiency of ADAP/Fyb/SLAP-130 destabilizes SKAP55 in Jurkat T cells

http://www.wikidata.org/entity/Q28246643

about

Regulation and function of SKAP-55 non-canonical motif binding to the SH3c domain of adhesion and degranulation-promoting adaptor protein The ADAP/SKAP55 signaling module regulates T-cell receptor-mediated integrin activation through plasma membrane targeting of Rap1 The Skap-hom Dimerization and PH Domains Comprise a 3′-Phosphoinositide-Gated Molecular Switch RIAM links the ADAP/SKAP-55 signaling module to Rap1, facilitating T-cell-receptor-mediated integrin activation ARAP, a Novel Adaptor Protein, Is Required for TCR Signaling and Integrin-Mediated Adhesion The N terminus of SKAP55 enables T cell adhesion to TCR and integrin ligands via distinct mechanisms.ADAP is required for normal alphaIIbbeta3 activation by VWF/GP Ib-IX-V and other agonists.Recruitment of dynein to the Jurkat immunological synapse The c-Abl tyrosine kinase regulates actin remodeling at the immune synapse SLP-76-ADAP adaptor module regulates LFA-1 mediated costimulation and T cell motility.The adapter protein SLP-76 mediates "outside-in" integrin signaling and function in T cells.Functional cooperation between the proteins Nck and ADAP is fundamental for actin reorganization.Macrophages require Skap2 and Sirpα for integrin-stimulated cytoskeletal rearrangement.Immune adaptor ADAP in T cells regulates HIV-1 transcription and cell-cell viral spread via different co-receptors CRK proteins selectively regulate T cell migration into inflamed tissues.ADAP interactions with talin and kindlin promote platelet integrin αIIbβ3 activation and stable fibrinogen binding.The pleckstrin homology domain in the SKAP55 adapter protein defines the ability of the adapter protein ADAP to regulate integrin function and NF-kappaB activation.ADAP and SKAP55 deficiency suppresses PD-1 expression in CD8+ cytotoxic T lymphocytes for enhanced anti-tumor immunotherapy.AlphaPIX Rho GTPase guanine nucleotide exchange factor regulates lymphocyte functions and antigen receptor signaling.Distinct regulation of integrin-dependent T cell conjugate formation and NF-kappa B activation by the adapter protein ADAP.SKAP-55, SKAP-55-related and ADAP adaptors modulate integrin-mediated immune-cell adhesion.T cell receptor "inside-out" pathway via signaling module SKAP1-RapL regulates T cell motility and interactions in lymph nodes The Role of SH2 Domain-containing Leukocyte Phosphoprotein of 76 kDa in the Regulation of Immune Cell Development and Function SKAP1 protein PH domain determines RapL membrane localization and Rap1 protein complex formation for T cell receptor (TCR) activation of LFA-1.The SLP-76 Src homology 2 domain is required for T cell development and activation.D120 and K152 within the PH Domain of T Cell Adapter SKAP55 Regulate Plasma Membrane Targeting of SKAP55 and LFA-1 Affinity Modulation in Human T Lymphocytes.SKAP1 is dispensable for chemokine-induced migration of primary T-cells Functional defects of SKAP-55-deficient T cells identify a regulatory role for the adaptor in LFA-1 adhesion An atlas of mouse CD4(+) T cell transcriptomes.Regulation of in vitro and in vivo immune functions by the cytosolic adaptor protein SKAP-HOM.Ubc9 Binds to ADAP and Is Required for Rap1 Membrane Recruitment, Rac1 Activation, and Integrin-Mediated T Cell Adhesion.Sailing to and Docking at the Immune Synapse: Role of Tubulin Dynamics and Molecular Motors.

P2860

Q24303850-61CE7E7F-17AF-46D7-8D79-B5B195E90E83 Q24670245-2C718EF7-8EC2-4B68-87FC-2E538BBA903A Q27652974-6730C193-ADB5-41E6-B8C6-24CAE7C53F97 Q28592022-6A8F6420-A967-45C0-80D5-2D95D0DF9329 Q28854571-E7E3DA40-ABDE-4892-A79B-B3BA27CD1F63 Q30009507-5B199926-4E74-46D6-B773-6E346391A2A9 Q30159628-7B116AFF-91C3-42E6-B7AE-A70ED31BB9CF Q30478093-AD447DAC-E1E1-4120-974E-BED6D150297A Q30482430-7083B264-2BDF-4B17-8B24-A5BE120FF4FE Q30488841-FCDEE65B-7C8D-4DF1-9FB0-6441E7D34A98 Q30490766-6897DC10-BAB6-42DF-A27A-E184D65BA899 Q30502363-58FFC2F0-E199-4848-AB25-AC987A772D38 Q30533919-68A864E3-B26F-41EB-AF33-4D87FAF587AC Q30558705-3BC785CC-2417-44F1-8DF8-7593E9A98FC0 Q30628412-79C934A3-0B8C-41C8-B0D0-5C7182E371F3 Q33621616-33B8A0D6-212A-449A-ABBB-A06D03590CA6 Q35025935-7BEA368D-A8CC-458C-A459-267E5973D472 Q35695370-D2C06133-C30D-4417-B977-62D4053079DC Q36711293-83404621-49A4-4E11-9374-EA5F3856913A Q36996023-D3E2335E-CA57-4FB0-943D-0D6578AA1162 Q37257440-0E615440-27DF-4DB5-A468-1FEB882D127E Q37267531-FB5196F5-D4D1-49B0-BDBB-CF1F124A84FE Q37682609-7204F53D-CBD1-4A60-B096-CA0218AA55AF Q38676163-8DECEE8A-3336-4F24-88FB-CE786F8A04C1 Q38829466-9828388E-2F13-495E-BE9F-626F466D156D Q39040159-65012845-E514-45DF-88D2-E306248C44DF Q39805672-71DE0161-C70C-4D41-AE0D-9DF7E397A591 Q40804411-56BB7B34-6F50-48E2-A438-A6512FD8821D Q41052256-91F3CC65-C871-4D29-90E8-7A85069621F3 Q42537490-AC9B69F2-CF1E-423C-829A-2CB1951F7EB8 Q47414975-B2178F2B-84BF-41D7-B694-B1B0DD5982AB Q55119821-A6C8A20A-3B01-475C-9963-D495C848C6CD

P2860

Deficiency of ADAP/Fyb/SLAP-130 destabilizes SKAP55 in Jurkat T cells

http://www.wikidata.org/entity/Q28246643

description

2005 nî lūn-bûn

@nan

2005 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի հունիսին հրատարակված գիտական հոդված

@hy

2005年の論文

@ja

2005年論文

@yue

2005年論文

@zh-hant

2005年論文

@zh-hk

2005年論文

@zh-mo

2005年論文

@zh-tw

2005年论文

@wuu

name

Deficiency of ADAP/Fyb/SLAP-130 destabilizes SKAP55 in Jurkat T cells

@ast

Deficiency of ADAP/Fyb/SLAP-130 destabilizes SKAP55 in Jurkat T cells

@en

Deficiency of ADAP/Fyb/SLAP-130 destabilizes SKAP55 in Jurkat T cells

@nl

type

label

Deficiency of ADAP/Fyb/SLAP-130 destabilizes SKAP55 in Jurkat T cells

@ast

Deficiency of ADAP/Fyb/SLAP-130 destabilizes SKAP55 in Jurkat T cells

@en

Deficiency of ADAP/Fyb/SLAP-130 destabilizes SKAP55 in Jurkat T cells

@nl

prefLabel

Deficiency of ADAP/Fyb/SLAP-130 destabilizes SKAP55 in Jurkat T cells

@ast

Deficiency of ADAP/Fyb/SLAP-130 destabilizes SKAP55 in Jurkat T cells

@en

Deficiency of ADAP/Fyb/SLAP-130 destabilizes SKAP55 in Jurkat T cells

@nl

P1433

Q28246643-11C95B53-9D80-4D8C-9F04-E2F1BB788189

P1476

Q28246643-AF90575D-51DC-4AA8-AB13-313ED704CD82

P2093

Q28246643-437FDFE6-CB85-4784-B166-C27F3100D14A

Q28246643-552C980D-A46A-4D9E-931A-34F2D671E154

Q28246643-58C1925D-F4C5-4EA3-A060-455212E3A91F

Q28246643-E38EB047-8FF9-4D7C-AA71-C61A49D9F24F

Q28246643-E7D6DACB-9228-49A8-A695-632F1E353CFA

Q28246643-FB9123FC-77E8-4172-B236-00B03C70DBEB

P2860

Q28246643-0932FDAA-8C4E-47FE-A985-E5C9E9FF40F1

Q28246643-094F8AF2-879E-4F78-A52E-E89ED2B3B545

Q28246643-0AA167D8-7CF6-41F3-843F-97E5B72EE444

Q28246643-11066C6A-E8B9-4373-B73E-A6D0687F339C

Q28246643-1E48C650-9D4F-4FB8-9C62-A61F8AE64BDA

Q28246643-230F2789-C7CA-4C3C-9C58-36C58D6E810D

Q28246643-347F4DD7-3BC2-40AA-AF25-5997BEE681C2

Q28246643-3A375C7C-D93D-4F2E-8047-26888489C5A8

Q28246643-3BC99784-3623-48B3-96AA-C1792728B94D

Q28246643-549593E0-556C-4725-96CD-4B8E1FBF618A

P304

Q28246643-55BE7015-8892-485F-A3E4-F4D7C8CE4187

P31

Q28246643-3A3189A5-8C4E-450F-B925-88F13FA9619A

P356

Q28246643-EBAC9AC5-5AEE-4D8D-93C2-938B78D55660

P407

Q28246643-0A503D54-9638-4921-894F-E74401877275

P433

Q28246643-52F36EDF-9728-443D-ADBF-E15101A6F05E

P478

Q28246643-9F45B1C2-0914-4410-BBA7-511744C60811

P577

Q28246643-482339E6-7A9E-4FB5-A9F0-F1BA3F126F0F

P698

Q28246643-BCEDD28A-87E5-4CAC-8A48-AD16375E5DCE

P356

P1433

Journal of Biological Chemistry

P1476

Deficiency of ADAP/Fyb/SLAP-130 destabilizes SKAP55 in Jurkat T cells

@en

P2093

Darrell D Norton

http://www.w3.org/2001/XMLSchema#string

Janis K Burkhardt

http://www.w3.org/2001/XMLSchema#string

Jennifer L Martindale

http://www.w3.org/2001/XMLSchema#string

Patricia Precht

http://www.w3.org/2001/XMLSchema#string

Ronald L Wange

http://www.w3.org/2001/XMLSchema#string

Yanping Huang

http://www.w3.org/2001/XMLSchema#string

P2860

FYN-T-FYB-SLP-76 interactions define a T-cell receptor zeta/CD3-mediated tyrosine phosphorylation pathway that up-regulates interleukin 2 transcription in T-cells

SKAP55 coupled with CD45 positively regulates T-cell receptor-mediated gene transcription

Molecular cloning of SKAP55, a novel protein that associates with the protein tyrosine kinase p59fyn in human T-lymphocytes

Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production

FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells

Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation

HuR regulates p21 mRNA stabilization by UV light

SH3 domain recognition of a proline-independent tyrosine-based RKxxYxxY motif in immune cell adaptor SKAP55

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

Novel isoform of lymphoid adaptor FYN-T-binding protein (FYB-130) interacts with SLP-76 and up-regulates interleukin 2 production

P304

23576-83

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1074/JBC.M413201200

http://www.w3.org/2001/XMLSchema#string

P407

P433

25

http://www.w3.org/2001/XMLSchema#string

P478

280

http://www.w3.org/2001/XMLSchema#string

P577

2005-06-24T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

15849195

http://www.w3.org/2001/XMLSchema#string