Rheb inhibits C-raf activity and B-raf/C-raf heterodimerization - Wikidata - wikimedia - TriplyDB

Rheb inhibits C-raf activity and B-raf/C-raf heterodimerization

Rheb inhibits C-raf activity and B-raf/C-raf heterodimerization

http://www.wikidata.org/entity/Q28248759

about

Raf family kinases: old dogs have learned new tricks Upregulation of the mammalian target of rapamycin complex 1 pathway by Ras homolog enriched in brain in pancreatic beta-cells leads to increased beta-cell mass and prevention of hyperglycemia The Key Role of Calmodulin in KRAS-Driven Adenocarcinomas Ras Homolog Enriched in Brain (Rheb) Enhances Apoptotic Signaling Non-canonical functions of the tuberous sclerosis complex-Rheb signalling axis Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer The evolutionarily conserved TSC/Rheb pathway activates Notch in tuberous sclerosis complex and Drosophila external sensory organ development.Rapamycin-insensitive up-regulation of MMP2 and other genes in tuberous sclerosis complex 2-deficient lymphangioleiomyomatosis-like cells.mTOR signaling in lymphangioleiomyomatosis Rapamycin-insensitive up-regulation of adipocyte phospholipase A2 in tuberous sclerosis and lymphangioleiomyomatosis.Rapamycin-resistant poly (ADP-ribose) polymerase-1 overexpression is a potential therapeutic target in lymphangioleiomyomatosis.Novel mechanism of regulation of the DNA repair enzyme OGG1 in tuberin-deficient cells.Mammalian target of rapamycin signaling and autophagy: roles in lymphangioleiomyomatosis therapy Metabotropic glutamate receptor-dependent long-term depression is impaired due to elevated ERK signaling in the ΔRG mouse model of tuberous sclerosis complex.Lymphangioleiomyomatosis - a wolf in sheep's clothing.A novel AKT inhibitor, AZD5363, inhibits phosphorylation of AKT downstream molecules, and activates phosphorylation of mTOR and SMG-1 dependent on the liver cancer cell type.Constitutively active Rheb induces oncogenic transformation.Estrogen promotes the survival and pulmonary metastasis of tuberin-null cells.Integration of mTOR and estrogen-ERK2 signaling in lymphangioleiomyomatosis pathogenesis.Feedback loops blockade potentiates apoptosis induction and antitumor activity of a novel AKT inhibitor DC120 in human liver cancer.A current viewpoint of lymphangioleiomyomatosis supporting immunotherapeutic treatment options.It takes two to tango--signalling by dimeric Raf kinases.Metformin in lung cancer: rationale for a combination therapy.Rheb signaling and tumorigenesis: mTORC1 and new horizons.Transcriptional and post-translational modifications of B-Raf in quinol-thioether induced tuberous sclerosis renal cell carcinoma.Targeting the mTOR pathway in breast cancer.NF-κB as the main node of resistance to receptor tyrosine kinase inhibitors in triple-negative breast cancer.Rheb may complex with RASSF1A to coordinate Hippo and TOR signaling.Formation of endothelial lumens requires a coordinated PKCepsilon-, Src-, Pak- and Raf-kinase-dependent signaling cascade downstream of Cdc42 activation Diacylglycerol kinase eta augments C-Raf activity and B-Raf/C-Raf heterodimerization.Rheb G-Proteins and the Activation of mTORC1.LKB1/KRAS mutant lung cancers constitute a genetic subset of NSCLC with increased sensitivity to MAPK and mTOR signalling inhibition.Fluorescence resonance energy transfer based quantitative analysis of feedforward and feedback loops in epidermal growth factor receptor signaling and the sensitivity to molecular targeting drugs.Tuberin regulates the DNA repair enzyme OGG1.Notch transactivates Rheb to maintain the multipotency of TSC-null cells.An oncogenic mutant of RHEB, RHEB Y35N, exhibits an altered interaction with BRAF resulting in cancer transformation.Exosomes mediate the acquisition of the disease phenotypes by cells with normal genome in tuberous sclerosis complex.

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P2860

Rheb inhibits C-raf activity and B-raf/C-raf heterodimerization

http://www.wikidata.org/entity/Q28248759

description

2006 nî lūn-bûn

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2006 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2006年の論文

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2006年学术文章

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2006年学术文章

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2006年学术文章

@zh-hans

2006年学术文章

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2006年学术文章

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2006年學術文章

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name

Rheb inhibits C-raf activity and B-raf/C-raf heterodimerization

@ast

Rheb inhibits C-raf activity and B-raf/C-raf heterodimerization

@en

Rheb inhibits C-raf activity and B-raf/C-raf heterodimerization

@nl

type

label

Rheb inhibits C-raf activity and B-raf/C-raf heterodimerization

@ast

Rheb inhibits C-raf activity and B-raf/C-raf heterodimerization

@en

Rheb inhibits C-raf activity and B-raf/C-raf heterodimerization

@nl

prefLabel

Rheb inhibits C-raf activity and B-raf/C-raf heterodimerization

@ast

Rheb inhibits C-raf activity and B-raf/C-raf heterodimerization

@en

Rheb inhibits C-raf activity and B-raf/C-raf heterodimerization

@nl

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P1433

Journal of Biological Chemistry

P1476

Rheb inhibits C-raf activity and B-raf/C-raf heterodimerization

@en

P2093

Elizabeth Petri Henske

http://www.w3.org/2001/XMLSchema#string

Magdalena Karbowniczek

http://www.w3.org/2001/XMLSchema#string

P2860

Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

Mutations of the BRAF gene in human cancer

TOR, a central controller of cell growth.

Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

B-Raf and Raf-1 are regulated by distinct autoregulatory mechanisms

A mammalian protein targeted by G1-arresting rapamycin-receptor complex

Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

P304

25447-25456

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scholarly article

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5033487

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10.1074/JBC.M605273200

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35

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P478

281

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Gavin P. Robertson

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2006-06-27T00:00:00Z

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16803888

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