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B-Raf and Raf-1 are regulated by distinct autoregulatory mechanisms

B-Raf and Raf-1 are regulated by distinct autoregulatory mechanisms

http://www.wikidata.org/entity/Q28235023

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Second nature: biological functions of the Raf-1 "kinase"IQGAP1 modulates activation of B-Raf Raf family kinases: old dogs have learned new tricks Differential regulation of B-raf isoforms by phosphorylation and autoinhibitory mechanisms ERK1 and ERK2 Map Kinases: Specific Roles or Functional Redundancy?Similar but different: distinct roles for KRAS and BRAF oncogenes in colorectal cancer development and therapy resistance The molecular biology of WHO grade I astrocytomas Ablation of BRaf impairs neuronal differentiation in the postnatal hippocampus and cerebellum Crystal structure of a BRAF kinase domain monomer explains basis for allosteric regulation Rheb inhibits C-raf activity and B-raf/C-raf heterodimerization Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas Impact of feedback phosphorylation and Raf heterodimerization on normal and mutant B-Raf signaling B-Raf regulation of integrin α4β1-mediated resistance to shear stress through changes in cell spreading and cytoskeletal association in T cells BRAF drives synovial fibroblast transformation in rheumatoid arthritis.Calcineurin increases glucose activation of ERK1/2 by reversing negative feedback.Engineering and Functional Characterization of Fusion Genes Identifies Novel Oncogenic Drivers of Cancer.Chromosome band 7q34 deletions resulting in KIAA1549-BRAF and FAM131B-BRAF fusions in pediatric low-grade Gliomas.PAK1 as a therapeutic target.Raf kinases: function, regulation and role in human cancer.A novel role for Cdk1/cyclin B in regulating B-raf activation at mitosis IMP modulates KSR1-dependent multivalent complex formation to specify ERK1/2 pathway activation and response thresholds p21 activated kinase 5 activates Raf-1 and targets it to mitochondria AKT upregulates B-Raf Ser445 phosphorylation and ERK1/2 activation in prostate cancer cells in response to androgen depletion.Selective Raf inhibition in cancer therapy.The distribution of BRAF gene fusions in solid tumors and response to targeted therapy.Pak protein kinases and their role in cancer.Mechanistic principles of RAF kinase signaling.IQGAP1: a regulator of intracellular spacetime relativity.MAP kinase signaling and inhibition in melanoma.PAK signaling in cancer.Tumor adaptation and resistance to RAF inhibitors.IQGAP1: insights into the function of a molecular puppeteer.Current Understanding of BRAF Alterations in Diagnosis, Prognosis, and Therapeutic Targeting in Pediatric Low-Grade Gliomas.Future of combination therapy with dabrafenib and trametinib in metastatic melanoma.A-Raf: A new star of the family of raf kinases.Analyses of PDE-regulated phosphoproteomes reveal unique and specific cAMP-signaling modules in T cells.P21-activated kinase 1 regulates resistance to BRAF inhibition in human cancer cells.The response to PAK1 inhibitor IPA3 distinguishes between cancer cells with mutations in BRAF and Ras oncogenes.Biomarkers classification and therapeutic decision-making for malignant gliomas.Assessment of SRM, MRM(3) , and DIA for the targeted analysis of phosphorylation dynamics in non-small cell lung cancer.

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P2860

B-Raf and Raf-1 are regulated by distinct autoregulatory mechanisms

http://www.wikidata.org/entity/Q28235023

description

2005 nî lūn-bûn

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2005 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2005 թվականի ապրիլին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

B-Raf and Raf-1 are regulated by distinct autoregulatory mechanisms

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B-Raf and Raf-1 are regulated by distinct autoregulatory mechanisms

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B-Raf and Raf-1 are regulated by distinct autoregulatory mechanisms

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type

label

B-Raf and Raf-1 are regulated by distinct autoregulatory mechanisms

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B-Raf and Raf-1 are regulated by distinct autoregulatory mechanisms

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B-Raf and Raf-1 are regulated by distinct autoregulatory mechanisms

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prefLabel

B-Raf and Raf-1 are regulated by distinct autoregulatory mechanisms

@ast

B-Raf and Raf-1 are regulated by distinct autoregulatory mechanisms

@en

B-Raf and Raf-1 are regulated by distinct autoregulatory mechanisms

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P1433

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P1433

Journal of Biological Chemistry

P1476

B-Raf and Raf-1 are regulated by distinct autoregulatory mechanisms

@en

P2093

Jeffrey A Frost

http://www.w3.org/2001/XMLSchema#string

Nancy H Tran

http://www.w3.org/2001/XMLSchema#string

Xiaochong Wu

http://www.w3.org/2001/XMLSchema#string

P2860

Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation

S338 phosphorylation of Raf-1 is independent of phosphatidylinositol 3-kinase and Pak3

Phosphorylation of Raf-1 serine 338-serine 339 is an essential regulatory event for Ras-dependent activation and biological signaling

Autoregulation of the Raf-1 serine/threonine kinase

Mutations of the BRAF gene in human cancer

Phosphorylation and regulation of Raf by Akt (protein kinase B)

Negative regulation of the serine/threonine kinase B-Raf by Akt

Mechanisms of regulating the Raf kinase family

Regulation of Raf through phosphorylation and N terminus-C terminus interaction

Interaction between active Pak1 and Raf-1 is necessary for phosphorylation and activation of Raf-1

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16244-53

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scholarly article

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952988

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10.1074/JBC.M501185200

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280

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15710605

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