Constitutively active Rheb induces oncogenic transformation.
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Structure-guided Mutation of the Conserved G3-box Glycine in Rheb Generates a Constitutively Activated Regulator of Mammalian Target of Rapamycin (mTOR)Computational modeling and analysis of insulin induced eukaryotic translation initiationDifferential requirement of CAAX-mediated posttranslational processing for Rheb localization and signalingRecent progress in the study of the Rheb family GTPases.Phosphatidylinositol 3-kinase: the oncoprotein.mTOR direct interactions with Rheb-GTPase and raptor: sub-cellular localization using fluorescence lifetime imaging.Oncogenic activity of the regulatory subunit p85β of phosphatidylinositol 3-kinase (PI3K)Suppression of the GTPase-activating protein RGS10 increases Rheb-GTP and mTOR signaling in ovarian cancer cells.Retrograde changes in presynaptic function driven by dendritic mTORC1.Fas-associated protein with death domain (FADD) regulates autophagy through promoting the expression of Ras homolog enriched in brain (Rheb) in human breast adenocarcinoma cellsAutophagy: regulation and role in disease.Influence of miR-155 on Cell Apoptosis in Rats with Ischemic Stroke: Role of the Ras Homolog Enriched in Brain (Rheb)/mTOR Pathway.Autophagy in cellular growth control.Amino acid sensing mechanisms: an Achilles heel in cancer?Analysis of Rheb in the cellular slime mold Dictyostelium discoideum: cellular localization, spatial expression and overexpression.Eukaryotic initiation factor 4E-binding protein 1 (4E-BP1): a master regulator of mRNA translation involved in tumorigenesis.Clonal evolution enhances leukemia-propagating cell frequency in T cell acute lymphoblastic leukemia through Akt/mTORC1 pathway activationExploration of Involved Key Genes and Signaling Diversity in Brain Tumors.Protein expression profiles of C3H 10T1/2 murine fibroblasts and of isogenic cells transformed by the H1047R mutant of phosphoinositide 3-kinase (PI3K).Epac1-induced cellular proliferation in prostate cancer cells is mediated by B-Raf/ERK and mTOR signaling cascades.Rheb may complex with RASSF1A to coordinate Hippo and TOR signaling.Lysosomal positioning coordinates cellular nutrient responses.Attenuation of TORC1 signaling delays replicative and oncogenic RAS-induced senescence.Regulation of mTORC1 complex assembly and signaling by GRp58/ERp57.Inhibition of MAPK pathway is essential for suppressing Rheb-Y35N driven tumor growth.Effects of RhebL1 silencing on the mTOR pathway.Rheb G-Proteins and the Activation of mTORC1.A Deregulated PI3K-AKT Signaling Pathway in Patients with Colorectal Cancer.RHEB1 expression in embryonic and postnatal mouse.Alkaline stress-induced autophagy is mediated by mTORC1 inactivation.
P2860
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P2860
Constitutively active Rheb induces oncogenic transformation.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Constitutively active Rheb induces oncogenic transformation.
@en
type
label
Constitutively active Rheb induces oncogenic transformation.
@en
prefLabel
Constitutively active Rheb induces oncogenic transformation.
@en
P2860
P356
P1433
P1476
Constitutively active Rheb induces oncogenic transformation.
@en
P2093
P2860
P2888
P304
P356
10.1038/ONC.2008.180
P407
P577
2008-06-02T00:00:00Z
P5875
P6179
1043320506