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Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90

Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90

http://www.wikidata.org/entity/Q28249103

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Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms Contribution of the Type II Chaperonin, TRiC/CCT, to Oncogenesis Maximizing the Therapeutic Potential of HSP90 Inhibitors Ganetespib: research and clinical development Steroid Receptor-Associated Immunophilins: A Gateway to Steroid Signalling Fine-tuning multiprotein complexes using small molecules Targeting Plasmodium falciparum Hsp90: Towards Reversing Antimalarial Resistance Advances in the clinical development of heat shock protein 90 (Hsp90) inhibitors in cancers Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2 Contribution of chaperones to STAT pathway signaling.Selective targeting of the stress chaperome as a therapeutic strategy Heat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an update Posttranslational modification and conformational state of heat shock protein 90 differentially affect binding of chemically diverse small molecule inhibitors Tumor selective cytotoxic action of a thiomorpholin hydroxamate inhibitor (TMI-1) in breast cancer Hsp90 inhibitors are efficacious against Kaposi Sarcoma by enhancing the degradation of the essential viral gene LANA, of the viral co-receptor EphA2 as well as other client proteins Dynamic impacts of the inhibition of the molecular chaperone Hsp90 on the T-cell proteome have implications for anti-cancer therapy Regulation and function of the human HSP90AA1 gene Phase II trial of panobinostat, an oral pan-deacetylase inhibitor in patients with primary myelofibrosis, post-essential thrombocythaemia, and post-polycythaemia vera myelofibrosis.The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative Diseases Kinome profiling reveals breast cancer heterogeneity and identifies targeted therapeutic opportunities for triple negative breast cancer Protein chaperones: a composition of matter review (2008 - 2013).How chemoproteomics can enable drug discovery and development Heat shock protein 90 inhibitors in the treatment of cancer: current status and future directions Auranofin induces lethal oxidative and endoplasmic reticulum stress and exerts potent preclinical activity against chronic lymphocytic leukemia.Probing molecular mechanisms of the Hsp90 chaperone: biophysical modeling identifies key regulators of functional dynamics.Induced protein degradation: an emerging drug discovery paradigm.Genomic and functional analysis of leukemic transformation of myeloproliferative neoplasms.Targeting heat-shock-protein 90 (Hsp90) by natural products: geldanamycin, a show case in cancer therapy.Development of a high-throughput screening cancer cell-based luciferase refolding assay for identifying Hsp90 inhibitors.HSP90 supports tumor growth and angiogenesis through PRKD2 protein stabilization.The heat shock protein 90 inhibitor, (-)-epigallocatechin gallate, has anticancer activity in a novel human prostate cancer progression model.Differential CARM1 Isoform Expression in Subcellular Compartments and among Malignant and Benign Breast Tumors.The HSP90 inhibitor ganetespib: A potential effective agent for Acute Myeloid Leukemia in combination with cytarabine Role of the novel HSP90 inhibitor AUY922 in hepatocellular carcinoma: Potential for therapy FS-93, an Hsp90 inhibitor, induces G2/M arrest and apoptosis via the degradation of client proteins in oncogene addicted and derived resistant cancer cells.Particulate cytoplasmic structures with high concentration of ubiquitin-proteasome accumulate in myeloid neoplasms.Inhibiting the HSP90 chaperone destabilizes macrophage migration inhibitory factor and thereby inhibits breast tumor progression.Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog Grp94 Combined HSP90 and kinase inhibitor therapy: Insights from The Cancer Genome Atlas.Heat shock protein gp96 regulates Toll-like receptor 9 proteolytic processing and conformational stability.

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Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90

http://www.wikidata.org/entity/Q28249103

description

2011 nî lūn-bûn

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2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90

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Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90

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Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90

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type

label

Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90

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Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90

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Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90

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prefLabel

Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90

@ast

Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90

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Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90

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Nature Chemical Biology

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Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90

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Anna Rodina

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Ari Melnick

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Danuta Zatorska

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Erica M Gomes DaGama

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Hongliang Zong

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James H Ahn

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Kamalika Moulick

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Katerina Hatzi

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Len Neckers

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Mary Alpaugh

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P2860

Charting the molecular network of the drug target Bcr-Abl

Protein kinase D2 mediates activation of nuclear factor kappaB by Bcr-Abl in Bcr-Abl+ human myeloid leukemia cells

DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome

An integrated genomic analysis of human glioblastoma multiforme

Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases

Regulation and function of IKK and IKK-related kinases

Structure, function, and regulation of STAT proteins

Involvement of SLP-65 and Btk in tumor suppression and malignant transformation of pre-B cells

Drugging the cancer chaperone HSP90: combinatorial therapeutic exploitation of oncogene addiction and tumor stress

Protein tyrosine phosphatases in the JAK/STAT pathway

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818-26

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scholarly article

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4761292

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10.1038/NCHEMBIO.670

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11

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7

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Hediye Erdjument-Bromage

Gabriela Chiosis

Eloisi Caldas-Lopes

Leandro Cerchietti

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2011-09-25T00:00:00Z

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51673360

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21946277

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3265389

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