Discovery of pyrrolo[2,3-b]pyrazines derivatives as submicromolar affinity activators of wild type, G551D, and F508del cystic fibrosis transmembrane conductance regulator chloride channels

Discovery of pyrrolo[2,3-b]pyrazines derivatives as submicromolar affinity activators of wild type, G551D, and F508del cystic fibrosis transmembrane conductance regulator chloride channels

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http://www.wikidata.org/entity/Q28250997
Lysosomal Re-acidification Prevents Lysosphingolipid-Induced Lysosomal Impairment and Cellular ToxicityCurcumin and genistein: the combined effects on disease-associated CFTR mutants and their clinical implicationsSelection of the biological activity of DNJ neoglycoconjugates through click length variation of the side chain.4-C-Me-DAB and 4-C-Me-LAB - enantiomeric alkyl-branched pyrrolidine iminosugars - are specific and potent α-glucosidase inhibitors; acetone as the sole protecting group.Dual activity of aminoarylthiazoles on the trafficking and gating defects of the cystic fibrosis transmembrane conductance regulator chloride channel caused by cystic fibrosis mutations.The multivalent effect in glycosidase inhibition: probing the influence of valency, peripheral ligand structure, and topology with cyclodextrin-based iminosugar click clusters.Rescue of functional CFTR channels in cystic fibrosis: a dramatic multivalent effect using iminosugar cluster-based correctors.N- and C-alkylation of seven-membered iminosugars generates potent glucocerebrosidase inhibitors and F508del-CFTR correctors.Stimulation of murine intestinal secretion by daily genistein injections: gender-dependent differencesCurcumin cross-links cystic fibrosis transmembrane conductance regulator (CFTR) polypeptides and potentiates CFTR channel activity by distinct mechanismsRepairing mutated proteins--development of small molecules targeting defects in the cystic fibrosis transmembrane conductance regulator.C terminus of nucleotide binding domain 1 contains critical features for cystic fibrosis transmembrane conductance regulator trafficking and activation.Modulation of cystic fibrosis transmembrane conductance regulator (CFTR) activity and genistein binding by cytosolic pH.Stimulation of Wild-Type, F508del- and G551D-CFTR Chloride Channels by Non-Toxic Modified pyrrolo[2,3-b]pyrazine Derivatives.Curcumin and genistein additively potentiate G551D-CFTR.Synthetic deoxynojirimycin derivatives bearing a thiolated, fluorinated or unsaturated N-alkyl chain: identification of potent α-glucosidase and trehalase inhibitors as well as F508del-CFTR correctors.
P2860

Discovery of pyrrolo[2,3-b]pyrazines derivatives as submicromolar affinity activators of wild type, G551D, and F508del cystic fibrosis transmembrane conductance regulator chloride channels

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http://www.wikidata.org/entity/Q28250997
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2006 nî lūn-bûn
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2006 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
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2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Discovery of pyrrolo[2,3-b]pyr ...... ce regulator chloride channels
@ast
Discovery of pyrrolo[2,3-b]pyr ...... ce regulator chloride channels
@en
Discovery of pyrrolo[2,3-b]pyr ...... ce regulator chloride channels
@nl
type
label
Discovery of pyrrolo[2,3-b]pyr ...... ce regulator chloride channels
@ast
Discovery of pyrrolo[2,3-b]pyr ...... ce regulator chloride channels
@en
Discovery of pyrrolo[2,3-b]pyr ...... ce regulator chloride channels
@nl
prefLabel
Discovery of pyrrolo[2,3-b]pyr ...... ce regulator chloride channels
@ast
Discovery of pyrrolo[2,3-b]pyr ...... ce regulator chloride channels
@en
Discovery of pyrrolo[2,3-b]pyr ...... ce regulator chloride channels
@nl
P1433
P1476
P2093
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698
P921
P356
P1433
P1476
Discovery of pyrrolo[2,3-b]pyr ...... ce regulator chloride channels
@en
P2093
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698
P921