Dual activity of aminoarylthiazoles on the trafficking and gating defects of the cystic fibrosis transmembrane conductance regulator chloride channel caused by cystic fibrosis mutations.
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CFTR Modulators: Shedding Light on Precision Medicine for Cystic FibrosisThe cystic fibrosis transmembrane conductance regulator (CFTR) and its stabilityLumacaftor/ivacaftor combination for cystic fibrosis patients homozygous for Phe508del-CFTR.Pharmacological Correctors of Mutant CFTR Mistrafficking.Cyanoquinolines with independent corrector and potentiator activities restore ΔPhe508-cystic fibrosis transmembrane conductance regulator chloride channel function in cystic fibrosis.Structure-activity relationships of cyanoquinolines with corrector-potentiator activity in ΔF508 cystic fibrosis transmembrane conductance regulator proteinChannel Gating Regulation by the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) First Cytosolic Loop.CFTR: folding, misfolding and correcting the ΔF508 conformational defect.Mechanism-based corrector combination restores ΔF508-CFTR folding and function.Targeting F508del-CFTR to develop rational new therapies for cystic fibrosis.Recent advances and new perspectives in targeting CFTR for therapy of cystic fibrosis and enterotoxin-induced secretory diarrheas.Functional Rescue of F508del-CFTR Using Small Molecule CorrectorsRepairing mutated proteins--development of small molecules targeting defects in the cystic fibrosis transmembrane conductance regulator.Cystic fibrosis transmembrane regulator correctors and potentiators.CFTR pharmacology.Trimethylangelicin promotes the functional rescue of mutant F508del CFTR protein in cystic fibrosis airway cells.Pseudohalide anions reveal a novel extracellular site for potentiators to increase CFTR function.Strategies for the etiological therapy of cystic fibrosis.Rescuing ΔF508 CFTR with trimethylangelicin, a dual-acting corrector and potentiator.The effect of ambroxol on chloride transport, CFTR and ENaC in cystic fibrosis airway epithelial cells.Partial rescue of F508del-CFTR channel gating with modest improvement of protein processing, but not stability by a dual-acting small molecule.Speeding Up the Identification of Cystic Fibrosis Transmembrane Conductance Regulator-Targeted Drugs: An Approach Based on Bioinformatics Strategies and Surface Plasmon Resonance.Thymosin α-1 does not correct F508del-CFTR in cystic fibrosis airway epithelia.Molecular Mechanism of Action of Trimethylangelicin Derivatives as CFTR Modulators.Molecular basis of cystic fibrosis: from bench to bedside
P2860
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P2860
Dual activity of aminoarylthiazoles on the trafficking and gating defects of the cystic fibrosis transmembrane conductance regulator chloride channel caused by cystic fibrosis mutations.
description
2011 nî lūn-bûn
@nan
2011 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մարտին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Dual activity of aminoarylthia ...... by cystic fibrosis mutations.
@ast
Dual activity of aminoarylthia ...... by cystic fibrosis mutations.
@en
Dual activity of aminoarylthia ...... by cystic fibrosis mutations.
@nl
type
label
Dual activity of aminoarylthia ...... by cystic fibrosis mutations.
@ast
Dual activity of aminoarylthia ...... by cystic fibrosis mutations.
@en
Dual activity of aminoarylthia ...... by cystic fibrosis mutations.
@nl
prefLabel
Dual activity of aminoarylthia ...... by cystic fibrosis mutations.
@ast
Dual activity of aminoarylthia ...... by cystic fibrosis mutations.
@en
Dual activity of aminoarylthia ...... by cystic fibrosis mutations.
@nl
P2093
P2860
P50
P356
P1476
Dual activity of aminoarylthia ...... d by cystic fibrosis mutations
@en
P2093
Emanuela Caci
Gianluca Damonte
Olga Zegarra-Moran
Valeria Tomati
P2860
P304
15215-15226
P356
10.1074/JBC.M110.184267
P407
P577
2011-03-07T00:00:00Z