A novel chromosomal translocation t(4; 14)(p16.3; q32) in multiple myeloma involves the fibroblast growth-factor receptor 3 gene
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Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activation8p12 stem cell myeloproliferative disorder: the FOP-fibroblast growth factor receptor 1 fusion protein of the t(6;8) translocation induces cell survival mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt/mTOR pathwaysTranslocation T(4;14)(p16.3;q32) is a recurrent genetic lesion in primary amyloidosisFGF signaling inhibits the proliferation of human myeloma cells and reduces c-myc expressionFunctional roles of fibroblast growth factor receptors (FGFRs) signaling in human cancersA Molecular Brake in the Kinase Hinge Region Regulates the Activity of Receptor Tyrosine KinasesInhibitor-sensitive FGFR1 amplification in human non-small cell lung cancer.Integrated genomic characterization reveals novel, therapeutically relevant drug targets in FGFR and EGFR pathways in sporadic intrahepatic cholangiocarcinomaAn integrative genomic approach reveals coordinated expression of intronic miR-335, miR-342, and miR-561 with deregulated host genes in multiple myeloma.Pleiotropic anti-myeloma activity of ITF2357: inhibition of interleukin-6 receptor signaling and repression of miR-19a and miR-19bFibroblast growth factor 19 expression correlates with tumor progression and poorer prognosis of hepatocellular carcinomaMultiple myeloma-associated chromosomal translocation activates orphan snoRNA ACA11 to suppress oxidative stress.The Fibroblast Growth Factor signaling pathwayRole of receptor tyrosine kinase transmembrane domains in cell signaling and human pathologies.MUC1 oncoprotein functions in activation of fibroblast growth factor receptor signalingCSNK1α1 mediates malignant plasma cell survival.Ligand activation leads to regulated intramembrane proteolysis of fibroblast growth factor receptor 3Immunohistochemical analysis of cyclin D1 shows deregulated expression in multiple myeloma with the t(11;14).Frequent FGFR3 mutations in papillary non-invasive bladder (pTa) tumorsMicrofluidic chips for detecting the t(4;14) translocation and monitoring disease during treatment using reverse transcriptase-polymerase chain reaction analysis of IgH-MMSET hybrid transcriptsIn multiple myeloma, bone-marrow lymphocytes harboring the same chromosomal abnormalities as autologous plasma cells predict poor survivalDrug-sensitive FGFR2 mutations in endometrial carcinomaThe role of senescence and prosurvival signaling in controlling the oncogenic activity of FGFR2 mutants associated with cancer and birth defects.Differential regulation of FGFR3 by PTPN1 and PTPN2.Ponatinib overcomes FGF2-mediated resistance in CML patients without kinase domain mutations.Elucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases.Targeting mutant fibroblast growth factor receptors in cancer.Fluorescence in situ hybridization analysis of immunoglobulin heavy chain translocations in plasma cell myeloma using intact paraffin sections and simultaneous CD138 immunofluorescence.Epigenetic strategies to reverse drug resistance in heterogeneous multiple myeloma.Knockdown by shRNA identifies S249C mutant FGFR3 as a potential therapeutic target in bladder cancer.MMSET deregulation affects cell cycle progression and adhesion regulons in t(4;14) myeloma plasma cells.Nordihydroguaiaretic acid inhibits an activated fibroblast growth factor receptor 3 mutant and blocks downstream signaling in multiple myeloma cellsMechanism of FGF receptor dimerization and activation.The t(4;14) translocation and FGFR3 overexpression in multiple myeloma: prognostic implications and current clinical strategies.A novel interaction between fibroblast growth factor receptor 3 and the p85 subunit of phosphoinositide 3-kinase: activation-dependent regulation of ERK by p85 in multiple myeloma cells.FGF2 from Marrow Microenvironment Promotes Resistance to FLT3 Inhibitors in Acute Myeloid Leukemia.
P2860
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P2860
A novel chromosomal translocation t(4; 14)(p16.3; q32) in multiple myeloma involves the fibroblast growth-factor receptor 3 gene
description
1997 nî lūn-bûn
@nan
1997 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
A novel chromosomal translocat ...... growth-factor receptor 3 gene
@ast
A novel chromosomal translocat ...... growth-factor receptor 3 gene
@en
A novel chromosomal translocat ...... growth-factor receptor 3 gene
@nl
type
label
A novel chromosomal translocat ...... growth-factor receptor 3 gene
@ast
A novel chromosomal translocat ...... growth-factor receptor 3 gene
@en
A novel chromosomal translocat ...... growth-factor receptor 3 gene
@nl
prefLabel
A novel chromosomal translocat ...... growth-factor receptor 3 gene
@ast
A novel chromosomal translocat ...... growth-factor receptor 3 gene
@en
A novel chromosomal translocat ...... growth-factor receptor 3 gene
@nl
P2093
P1433
P1476
A novel chromosomal translocat ...... growth-factor receptor 3 gene
@en
P2093
A T Maiolo
D Ronchetti
L Lombardi
L Viggiano
R Marzella
R Richelda
P304
P407
P577
1997-11-15T00:00:00Z