Direct interaction between Shc and the platelet-derived growth factor beta-receptor
about
Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domainRequirement of phospholipase C gamma, the tyrosine phosphatase Syp and the adaptor proteins Shc and Nck for PDGF-induced DNA synthesis: evidence for the existence of Ras-dependent and Ras-independent pathwaysA mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brainTyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activationAdditive effects of PDGF receptor beta signaling pathways in vascular smooth muscle cell developmentSolution structure of the Shc SH2 domain complexed with a tyrosine-phosphorylated peptide from the T-cell receptorThe ShcA phosphotyrosine docking protein sensitizes cardiovascular signaling in the mouse embryoEvidence for a role for the phosphotyrosine-binding domain of Shc in interleukin 2 signalingEvidence for a requirement for both phospholipid and phosphotyrosine binding via the Shc phosphotyrosine-binding domain in vivoP66Shc signals to age.Hyperglycemia-induced p66shc inhibits insulin-like growth factor I-dependent cell survival via impairment of Src kinase-mediated phosphoinositide-3 kinase/AKT activation in vascular smooth muscle cells.Mitochondrial longevity pathwaysDifferential signaling by adaptor molecules LRP1 and ShcA regulates adipogenesis by the insulin-like growth factor-1 receptorTargeting receptor tyrosine kinases and their downstream signaling with cell-penetrating peptides in human pulmonary artery smooth muscle and endothelial cellsShc adaptor proteins are key transducers of mitogenic signaling mediated by the G protein-coupled thrombin receptorShc proteins influence the activities of enzymes involved in fatty acid oxidation and ketogenesis.Ligand-independent activation of the platelet-derived growth factor beta receptor: requirements for bovine papillomavirus E5-induced mitogenic signaling.The GTPase-activating protein of Ras suppresses platelet-derived growth factor beta receptor signaling by silencing phospholipase C-gamma 1Mitogen-activated protein kinase activation is insufficient for growth factor receptor-mediated PC12 cell differentiation.A Drosophila shc gene product is implicated in signaling by the DER receptor tyrosine kinase.Platelet-derived growth factor-dependent activation of phosphatidylinositol 3-kinase is regulated by receptor binding of SH2-domain-containing proteins which influence Ras activityp66shc negatively regulates insulin-like growth factor I signal transduction via inhibition of p52shc binding to Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 leading to impaired growth factor receptor-bound protein-2 memThe interactome of the amyloid beta precursor protein family members is shaped by phosphorylation of their intracellular domains.Association and direct activation of signal transducer and activator of transcription1alpha by platelet-derived growth factor receptor.Identification of residues that control specific binding of the Shc phosphotyrosine-binding domain to phosphotyrosine sites.Polyomavirus large T antigen induces alterations in cytoplasmic signalling pathways involving Shc activation.Sch proteins are localized on endoplasmic reticulum membranes and are redistributed after tyrosine kinase receptor activation.Effect of nutritional state on the formation of a complex involving insulin receptor IRS-1, the 52 kDa Src homology/collagen protein (Shc) isoform and phosphatidylinositol 3'-kinase activitySignal transduction by epidermal growth factor and heregulin via the kinase-deficient ErbB3 protein.Spatial signaling networks converge at the adaptor protein Shc.Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway.
P2860
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P2860
Direct interaction between Shc and the platelet-derived growth factor beta-receptor
description
1994 nî lūn-bûn
@nan
1994 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
Direct interaction between Shc and the platelet-derived growth factor beta-receptor
@ast
Direct interaction between Shc and the platelet-derived growth factor beta-receptor
@en
Direct interaction between Shc and the platelet-derived growth factor beta-receptor
@nl
type
label
Direct interaction between Shc and the platelet-derived growth factor beta-receptor
@ast
Direct interaction between Shc and the platelet-derived growth factor beta-receptor
@en
Direct interaction between Shc and the platelet-derived growth factor beta-receptor
@nl
prefLabel
Direct interaction between Shc and the platelet-derived growth factor beta-receptor
@ast
Direct interaction between Shc and the platelet-derived growth factor beta-receptor
@en
Direct interaction between Shc and the platelet-derived growth factor beta-receptor
@nl
P2093
P1476
Direct interaction between Shc and the platelet-derived growth factor beta-receptor
@en
P2093
P304
15337-15343
P407
P577
1994-05-01T00:00:00Z