Hypoxia-inducible factor prolyl hydroxylase 2 has a high affinity for ferrous iron and 2-oxoglutarate
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Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygenStructural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediatesStudies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assayAscorbate as a co-factor for fe- and 2-oxoglutarate dependent dioxygenases: physiological activity in tumor growth and progressionInvestigating the contribution of the active site environment to the slow reaction of hypoxia-inducible factor prolyl hydroxylase domain 2 with oxygenStructural analysis of cofactor binding for a prolyl 4-hydroxylase from the pathogenic bacterium Bacillus anthracisThe serine protease TMPRSS6 is required to sense iron deficiencyInhibition of 2-oxoglutarate dependent oxygenasesThe role of PHD2 mutations in the pathogenesis of erythrocytosis.Normal tissue radioprotection by amifostine via Warburg-type effectsPlant cysteine oxidases are dioxygenases that directly enable arginyl transferase-catalysed arginylation of N-end rule targets.Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases.A photoreactive small-molecule probe for 2-oxoglutarate oxygenases.Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitorsHuman oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylationReporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors.Protein Hydroxylation Catalyzed by 2-Oxoglutarate-dependent Oxygenases.Vitamin C is dispensable for oxygen sensing in vivoThe redox basis of epigenetic modifications: from mechanisms to functional consequences.Structure and Mechanism of a Viral Collagen Prolyl HydroxylaseNon-heme dioxygenases: cellular sensors and regulators jelly rolled into one?Signaling hypoxia by hypoxia-inducible factor protein hydroxylases: a historical overview and future perspectivesProlyl 4-hydroxylases, key enzymes in the synthesis of collagens and regulation of the response to hypoxia, and their roles as treatment targets.Oxygen sensing and hypoxia signalling pathways in animals: the implications of physiology for cancer.Prolyl 4-hydroxylases, master regulators of the hypoxia response.Structure-based drug design for hypoxia-inducible factor prolyl-hydroxylase inhibitors and its therapeutic potential for the treatment of erythropoiesis-stimulating agent-resistant anemia: raising expectations for exploratory clinical trials.Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases.Understanding complexity in the HIF signaling pathway using systems biology and mathematical modeling.The Role of Hypoxia-Inducible Factor 1 in Mild Cognitive Impairment.Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion.Bacillus anthracis Prolyl 4-Hydroxylase Modifies Collagen-like Substrates in Asymmetric Patterns.Selective inhibition of the hypoxia-inducible factor prolyl hydroxylase PHD3 by Zn(II).Dynamic states of the DNA repair enzyme AlkB regulate product release.Kinetic Analysis of HIF Prolyl Hydroxylases.2-Oxoglutarate regulates binding of hydroxylated hypoxia-inducible factor to prolyl hydroxylase domain 2.
P2860
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P2860
Hypoxia-inducible factor prolyl hydroxylase 2 has a high affinity for ferrous iron and 2-oxoglutarate
description
2005 nî lūn-bûn
@nan
2005 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Hypoxia-inducible factor proly ...... errous iron and 2-oxoglutarate
@ast
Hypoxia-inducible factor proly ...... errous iron and 2-oxoglutarate
@en
Hypoxia-inducible factor proly ...... errous iron and 2-oxoglutarate
@nl
type
label
Hypoxia-inducible factor proly ...... errous iron and 2-oxoglutarate
@ast
Hypoxia-inducible factor proly ...... errous iron and 2-oxoglutarate
@en
Hypoxia-inducible factor proly ...... errous iron and 2-oxoglutarate
@nl
prefLabel
Hypoxia-inducible factor proly ...... errous iron and 2-oxoglutarate
@ast
Hypoxia-inducible factor proly ...... errous iron and 2-oxoglutarate
@en
Hypoxia-inducible factor proly ...... errous iron and 2-oxoglutarate
@nl
P2093
P50
P3181
P356
P1433
P1476
Hypoxia-inducible factor proly ...... errous iron and 2-oxoglutarate
@en
P2093
Dominic Ehrismann
Gunnar Jeschke
Ian J Clifton
Kirsty S Hewitson
Luke A McNeill
Matthew R G Buck
Timothy D W Claridge
P3181
P356
10.1039/B511249B
P407
P577
2005-10-01T00:00:00Z