p53-Independent ceramide formation in human glioma cells during gamma-radiation-induced apoptosis
about
Neutral sphingomyelinase-3 is a DNA damage and nongenotoxic stress-regulated gene that is deregulated in human malignanciesCeramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphateA house divided: ceramide, sphingosine, and sphingosine-1-phosphate in programmed cell deathEvolving concepts in cancer therapy through targeting sphingolipid metabolismAcid ceramidase is a novel drug target for pediatric brain tumors.Acid ceramidase upregulation in prostate cancer cells confers resistance to radiation: AC inhibition, a potential radiosensitizer.p53-independent early and late apoptosis is mediated by ceramide after exposure of tumor cells to photon or carbon ion irradiation.Glioma cell death induced by irradiation or alkylating agent chemotherapy is independent of the intrinsic ceramide pathway.Apoptotic sphingolipid ceramide in cancer therapy.Cancer treatment strategies targeting sphingolipid metabolism.Treating Brain Tumor with Microbeam Radiation Generated by a Compact Carbon-Nanotube-Based Irradiator: Initial Radiation Efficacy StudyAnticancer actions of lysosomally targeted inhibitor, LCL521, of acid ceramidaseRNAi based approaches to the treatment of malignant glioma.Acid Ceramidase in Melanoma: EXPRESSION, LOCALIZATION, AND EFFECTS OF PHARMACOLOGICAL INHIBITIONThe unexpected role of acid sphingomyelinase in cell death and the pathophysiology of common diseases.Alkaline ceramidase 2 and its bioactive product sphingosine are novel regulators of the DNA damage responseMolecular targeting of acid ceramidase: implications to cancer therapy.Transcriptome analysis of glioma cells for the dynamic response to γ-irradiation and dual regulation of apoptosis genes: a new insight into radiotherapy for glioblastomas.Alkaline ceramidase 2 is a novel direct target of p53 and induces autophagy and apoptosis through ROS generation.p53 and regulation of bioactive sphingolipids.Sphingolipids: key regulators of apoptosis and pivotal players in cancer drug resistanceSphingolipids in the DNA damage response.SapC-DOPS nanovesicles: a novel targeted agent for the imaging and treatment of glioblastomaTargeting acid sphingomyelinase with anti-angiogenic chemotherapy.Radiation-induced acid ceramidase confers prostate cancer resistance and tumor relapse.Metabolic Reprogramming in Glioma.Phosphatidylinositol 3-kinase/AKT pathway regulates the endoplasmic reticulum to golgi traffic of ceramide in glioma cells: a link between lipid signaling pathways involved in the control of cell survival.P53-dependent upregulation of neutral sphingomyelinase-2: role in doxorubicin-induced growth arrest.C6-ceramide and targeted inhibition of acid ceramidase induce synergistic decreases in breast cancer cell growth.Genomic alterations during p53-dependent apoptosis induced by γ-irradiation of Molt-4 leukemia cells.Acid ceramidase and its inhibitors: a de novo drug target and a new class of drugs for killing glioblastoma cancer stem cells with high efficiency.Molecular Targeting of Acid Ceramidase in Glioblastoma: A Review of Its Role, Potential Treatment, and Challenges.Effects of ionizing radiation on the viability and proliferative behavior of the human glioblastoma T98G cell line.Molecular Markers of Therapy-Resistant Glioblastoma and Potential Strategy to Combat Resistance.
P2860
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P2860
p53-Independent ceramide formation in human glioma cells during gamma-radiation-induced apoptosis
description
2004 nî lūn-bûn
@nan
2004 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
p53-Independent ceramide forma ...... ma-radiation-induced apoptosis
@ast
p53-Independent ceramide forma ...... ma-radiation-induced apoptosis
@en
p53-Independent ceramide forma ...... ma-radiation-induced apoptosis
@nl
type
label
p53-Independent ceramide forma ...... ma-radiation-induced apoptosis
@ast
p53-Independent ceramide forma ...... ma-radiation-induced apoptosis
@en
p53-Independent ceramide forma ...... ma-radiation-induced apoptosis
@nl
prefLabel
p53-Independent ceramide forma ...... ma-radiation-induced apoptosis
@ast
p53-Independent ceramide forma ...... ma-radiation-induced apoptosis
@en
p53-Independent ceramide forma ...... ma-radiation-induced apoptosis
@nl
P2093
P356
P1476
p53-Independent ceramide forma ...... ma-radiation-induced apoptosis
@en
P2093
S Nakashima
S Yoshimura
P2888
P304
P356
10.1038/SJ.CDD.4401428
P407
P577
2004-08-01T00:00:00Z