The unexpected role of acid sphingomyelinase in cell death and the pathophysiology of common diseases.
about
Identification of novel functional inhibitors of acid sphingomyelinaseSyntaxin 4 is required for acid sphingomyelinase activity and apoptotic functionMembrane progesterone receptors: evidence for neuroprotective, neurosteroid signaling and neuroendocrine functions in neuronal cellsLysosomal storage diseases and the heat shock response: convergences and therapeutic opportunitiesHsp70.1 and related lysosomal factors for necrotic neuronal deathASM-3 acid sphingomyelinase functions as a positive regulator of the DAF-2/AGE-1 signaling pathway and serves as a novel anti-aging targetCellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disordersAcid sphingomyelinase as target of Lycium Chinense: promising new action for cell healthHyperresponsiveness of mice deficient in plasma-secreted sphingomyelinase reveals its pivotal role in early phase of host responseDevelopmentally regulated sphingolipid degradation in Leishmania majorLipid alterations in experimental murine colitis: role of ceramide and imipramine for matrix metalloproteinase-1 expression.Stress-induced sphingolipid signaling: role of type-2 neutral sphingomyelinase in murine cell apoptosis and proliferation.Acid sphingomyelinase deficiency in Western diet-fed mice protects against adipocyte hypertrophy and diet-induced liver steatosis.Adjustment of Dysregulated Ceramide Metabolism in a Murine Model of Sepsis-Induced Cardiac Dysfunction.Sphingomyelinases: their regulation and roles in cardiovascular pathophysiology.Sphingomyelin metabolism at the plasma membrane: implications for bioactive sphingolipids.Production of multiple brain-like ganglioside species is dispensable for fas-induced apoptosis of lymphoid cellsInhibition of cytokine signaling in human retinal endothelial cells through downregulation of sphingomyelinases by docosahexaenoic acid.Acid sphingomyelinase modulates the autophagic process by controlling lysosomal biogenesis in Alzheimer's disease.Intra-articular enzyme replacement therapy with rhIDUA is safe, well-tolerated, and reduces articular GAG storage in the canine model of mucopolysaccharidosis type I.Acidic sphingomyelinase controls hepatic stellate cell activation and in vivo liver fibrogenesisLung injury and cancer: Mechanistic insights into ceramide and EGFR signaling under cigarette smoke.Regulated secretion of acid sphingomyelinase: implications for selectivity of ceramide formation.α-TEA-induced death receptor dependent apoptosis involves activation of acid sphingomyelinase and elevated ceramide-enriched cell surface membranesAcid sphingomyelinase gene knockout ameliorates hyperhomocysteinemic glomerular injury in mice lacking cystathionine-β-synthaseInhibition of acidic sphingomyelinase reduces established hepatic fibrosis in miceAcid sphingomyelinase deficiency attenuates bleomycin-induced lung inflammation and fibrosis in mice.Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppressionGlioma cell death induced by irradiation or alkylating agent chemotherapy is independent of the intrinsic ceramide pathway.Apoptotic sphingolipid ceramide in cancer therapy.Regulation of CC ligand 5/RANTES by acid sphingomyelinase and acid ceramidase.Ceramide synthase-dependent ceramide generation and programmed cell death: involvement of salvage pathway in regulating postmitochondrial events.Neutral sphingomyelinase 2: a novel target in cigarette smoke-induced apoptosis and lung injury.Critical modifier role of membrane-cystic fibrosis transmembrane conductance regulator-dependent ceramide signaling in lung injury and emphysema.Nutritional deficiencies and phospholipid metabolism.Overexpressed PKCδ downregulates the expression of PKCα in B16F10 melanoma: induction of apoptosis by PKCδ via ceramide generation.Acid sphingomyelinase gene deficiency ameliorates the hyperhomocysteinemia-induced glomerular injury in mice.Ceramides as modulators of cellular and whole-body metabolismAlternative splicing of SMPD1 in human sepsis.Cathepsin B overexpression due to acid sphingomyelinase ablation promotes liver fibrosis in Niemann-Pick disease.
P2860
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P2860
The unexpected role of acid sphingomyelinase in cell death and the pathophysiology of common diseases.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
The unexpected role of acid sp ...... physiology of common diseases.
@en
type
label
The unexpected role of acid sp ...... physiology of common diseases.
@en
prefLabel
The unexpected role of acid sp ...... physiology of common diseases.
@en
P2860
P356
P1433
P1476
The unexpected role of acid sp ...... physiology of common diseases.
@en
P2093
Edward H Schuchman
Eric L Smith
P2860
P304
P356
10.1096/FJ.08-108043
P407
P577
2008-06-20T00:00:00Z