Molecular targeting of acid ceramidase: implications to cancer therapy.
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Tamoxifen regulation of sphingolipid metabolism--Therapeutic implicationsA catalytic mechanism for cysteine N-terminal nucleophile hydrolases, as revealed by free energy simulationsThe emergence of acid ceramidase as a therapeutic target for acute myeloid leukemia.Acid ceramidase is upregulated in AML and represents a novel therapeutic target.Modification of sphingolipid metabolism by tamoxifen and N-desmethyltamoxifen in acute myelogenous leukemia--Impact on enzyme activity and response to cytotoxics.Acid ceramidase is a novel drug target for pediatric brain tumors.Mitochondrial dysfunction and increased reactive oxygen species impair insulin secretion in sphingomyelin synthase 1-null mice.Regulation of CC ligand 5/RANTES by acid sphingomyelinase and acid ceramidase.Ceramide kinase promotes tumor cell survival and mammary tumor recurrence.Clinical utility of serum autoantibodies detected by protein microarray in melanomaActivity of neutral and alkaline ceramidases on fluorogenic N-acylated coumarin-containing aminodiols.Stinging Nettle (Urtica dioica L.) Attenuates FFA Induced Ceramide Accumulation in 3T3-L1 Adipocytes in an Adiponectin Dependent Manner.Tamoxifen magnifies therapeutic impact of ceramide in human colorectal cancer cells independent of p53.Akt2 and acid ceramidase cooperate to induce cell invasion and resistance to apoptosisConstruction of conditional acid ceramidase knockout mice and in vivo effects on oocyte development and fertility.Deoxycholate promotes survival of breast cancer cells by reducing the level of pro-apoptotic ceramide.Acid ceramidase upregulation in prostate cancer: role in tumor development and implications for therapyGlucocerebroside: an evolutionary advantage for patients with Gaucher disease and a new immunomodulatory agent.Ceramide and ceramide 1-phosphate in health and disease.Interaction of acid ceramidase inhibitor LCL521 with tumor response to photodynamic therapy and photodynamic therapy-generated vaccine.Increased acid ceramidase expression depends on upregulation of androgen-dependent deubiquitinases, USP2, in a human prostate cancer cell line, LNCaP.Prostate cell lines as models for biomarker discovery: performance of current markers and the search for new biomarkers.Potential role of acid ceramidase in conversion of cytostatic to cytotoxic end-point in pancreatic cancer cells.Ceramide metabolism determines glioma cell resistance to chemotherapy.Complete Acid Ceramidase ablation prevents cancer-initiating cell formation in melanoma cells.Sphingomyelinase-like phosphodiesterase 3b mediates radiation-induced damage of renal podocytes.Acid ceramidase confers radioresistance to glioblastoma cells.Ceranib-2-induced suicidal erythrocyte death.Acid ceramidase and its inhibitors: a de novo drug target and a new class of drugs for killing glioblastoma cancer stem cells with high efficiency.The investigation of ceranib-2 on apoptosis and drug interaction with carboplatin in human non small cell lung cancer cells in vitro.Identification of the N-acylsphingosine amidohydrolase 1 gene (ASAH1) for susceptibility to schizophrenia in a Han Chinese population.Molecular Targeting of Acid Ceramidase in Glioblastoma: A Review of Its Role, Potential Treatment, and Challenges.A fluorescent probe for imaging symmetric and asymmetric cell division in neurosphere formation.A Ceramide-Regulated Element in the Late Endosomal Protein LAPTM4B Controls Amino Acid Transporter Interaction.Molecular Markers of Therapy-Resistant Glioblastoma and Potential Strategy to Combat Resistance.
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Molecular targeting of acid ceramidase: implications to cancer therapy.
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article científic
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article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on August 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Molecular targeting of acid ceramidase: implications to cancer therapy.
@en
Molecular targeting of acid ceramidase: implications to cancer therapy.
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type
label
Molecular targeting of acid ceramidase: implications to cancer therapy.
@en
Molecular targeting of acid ceramidase: implications to cancer therapy.
@nl
prefLabel
Molecular targeting of acid ceramidase: implications to cancer therapy.
@en
Molecular targeting of acid ceramidase: implications to cancer therapy.
@nl
P2093
P2860
P1433
P1476
Molecular targeting of acid ceramidase: implications to cancer therapy
@en
P2093
James S Norris
John B Korman
Russell W Jenkins
Youssef H Zeidan
P2860
P304
P356
10.2174/138945008785132358
P577
2008-08-01T00:00:00Z