Murine Ksr interacts with MEK and inhibits Ras-induced transformation
about
KSR-1 binds to G-protein betagamma subunits and inhibits beta gamma-induced mitogen-activated protein kinase activationThe MEK1 scaffolding protein MP1 regulates cell spreading by integrating PAK1 and Rho signals.Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactionsMechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the raf kinase inhibitor proteinInflammatory bowel disease reveals the kinase activity of KSR1Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists.KSR1 is a functional protein kinase capable of serine autophosphorylation and direct phosphorylation of MEK1Functional analysis of CNK in RAS signalingDifferential regulation of B-raf isoforms by phosphorylation and autoinhibitory mechanismsFunctional Integration of the Conserved Domains of Shoc2 ScaffoldA Raf-induced allosteric transition of KSR stimulates phosphorylation of MEKNegative feedback regulation of the ERK1/2 MAPK pathwayRIP2 is a Raf1-activated mitogen-activated protein kinase kinaseEpidermal growth factor treatment enhances the kinase activity of kinase suppressor of RasMEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathwayMEK kinase 2 binds and activates protein kinase C-related kinase 2. Bifurcation of kinase regulatory pathways at the level of an MAPK kinase kinaseIdentification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signalingInteraction of the Grb10 adapter protein with the Raf1 and MEK1 kinasesA CC-SAM, for coiled coil-sterile α motif, domain targets the scaffold KSR-1 to specific sites in the plasma membraneMEK kinase activity is not necessary for Raf-1 function.KSR2 is a calcineurin substrate that promotes ERK cascade activation in response to calcium signalsKinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localizationIdentification of B-KSR1, a novel brain-specific isoform of KSR1 that functions in neuronal signalingIdentification of constitutive and ras-inducible phosphorylation sites of KSR: implications for 14-3-3 binding, mitogen-activated protein kinase binding, and KSR overexpressionModulation of kinase activity and oncogenic properties by alternative splicing reveals a novel regulatory mechanism for B-RafThe RAF proteins take centre stageA lin-45 raf enhancer screen identifies eor-1, eor-2 and unusual alleles of Ras pathway genes in Caenorhabditis elegansERK MAP kinase is targeted to RSK2 by the phosphoprotein PEA-15.Filamin repeat segments required for photosensory signalling in Dictyostelium discoideum.How Genetics Has Helped Piece Together the MAPK Signaling Pathway.A preformed signaling complex mediates GnRH-activated ERK phosphorylation of paxillin and FAK at focal adhesions in L beta T2 gonadotrope cells.Cancer models in Caenorhabditis elegans.Proteomics in the liver of gilthead sea bream (Sparus aurata) to elucidate the cellular response induced by the intake of maslinic acid.Induction of postmitotic neuroretina cell proliferation by distinct Ras downstream signaling pathways.Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo.Extracellular signal-regulated kinase regulates clathrin-independent endosomal trafficking.KSR2 mutations are associated with obesity, insulin resistance, and impaired cellular fuel oxidation.A misexpression screen identifies genes that can modulate RAS1 pathway signaling in Drosophila melanogasterA genetic screen for modifiers of a kinase suppressor of Ras-dependent rough eye phenotype in Drosophila.Overexpression of kinase suppressor of Ras upregulates the high-molecular-weight tropomyosin isoforms in ras-transformed NIH 3T3 fibroblasts
P2860
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P2860
Murine Ksr interacts with MEK and inhibits Ras-induced transformation
description
1998 nî lūn-bûn
@nan
1998 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Murine Ksr interacts with MEK and inhibits Ras-induced transformation
@ast
Murine Ksr interacts with MEK and inhibits Ras-induced transformation
@en
Murine Ksr interacts with MEK and inhibits Ras-induced transformation
@nl
type
label
Murine Ksr interacts with MEK and inhibits Ras-induced transformation
@ast
Murine Ksr interacts with MEK and inhibits Ras-induced transformation
@en
Murine Ksr interacts with MEK and inhibits Ras-induced transformation
@nl
prefLabel
Murine Ksr interacts with MEK and inhibits Ras-induced transformation
@ast
Murine Ksr interacts with MEK and inhibits Ras-induced transformation
@en
Murine Ksr interacts with MEK and inhibits Ras-induced transformation
@nl
P2093
P3181
P1433
P1476
Murine Ksr interacts with MEK and inhibits Ras-induced transformation
@en
P2093
A Denouel-Galy
E M Douville
P3181
P356
10.1016/S0960-9822(98)70019-3
P407
P577
1998-01-01T00:00:00Z