The AXH domain of Ataxin-1 mediates neurodegeneration through its interaction with Gfi-1/Senseless proteins
about
Drosophila NMNAT maintains neural integrity independent of its NAD synthesis activityCHIP protects from the neurotoxicity of expanded and wild-type ataxin-1 and promotes their ubiquitination and degradationDevelopment and application of a DNA microarray-based yeast two-hybrid systemThe role of LANP and ataxin 1 in E4F-mediated transcriptional repressionPathogenic mechanisms of a polyglutamine-mediated neurodegenerative disease, spinocerebellar ataxia type 1Cell biology of spinocerebellar ataxiaBeyond the glutamine expansion: influence of posttranslational modifications of ataxin-1 in the pathogenesis of spinocerebellar ataxia type 1The unstable repeats--three evolving faces of neurological diseaseA Drosophila model of ALS: human ALS-associated mutation in VAP33A suggests a dominant negative mechanismPolyglutamine expansion accelerates the dynamics of ataxin-1 and does not result in aggregate formation.dAtaxin-2 mediates expanded Ataxin-1-induced neurodegeneration in a Drosophila model of SCA1Structural basis of protein complex formation and reconfiguration by polyglutamine disease protein Ataxin-1 and CapicuaSelf-Assembly and Conformational Heterogeneity of the AXH Domain of Ataxin-1: An Unusual Example of a Chameleon FoldProtein-protein interactions as a strategy towards protein-specific drug design: the example of ataxin-1The promise and perils of HDAC inhibitors in neurodegenerationDrosophila as an In Vivo Model for Human Neurodegenerative DiseaseOpposing effects of polyglutamine expansion on native protein complexes contribute to SCA1Protein misfolding and aggregation in Alzheimer's disease and type 2 diabetes mellitusPhosphorylation of S776 and 14-3-3 binding modulate ataxin-1 interaction with splicing factorsAtaxin1L is a regulator of HSC function highlighting the utility of cross-tissue comparisons for gene discoveryPartial loss of ataxin-1 function contributes to transcriptional dysregulation in spinocerebellar ataxia type 1 pathogenesisProtein arginine methyltransferase 6 enhances polyglutamine-expanded androgen receptor function and toxicity in spinal and bulbar muscular atrophy.Conformational fluctuations of the AXH monomer of Ataxin-1.Gcn5 loss-of-function accelerates cerebellar and retinal degeneration in a SCA7 mouse model.Native functions of the androgen receptor are essential to pathogenesis in a Drosophila model of spinobulbar muscular atrophy.Overexpression of wild-type androgen receptor in muscle recapitulates polyglutamine disease.SCA1-like disease in mice expressing wild-type ataxin-1 with a serine to aspartic acid replacement at residue 776.Prenatal flutamide enhances survival in a myogenic mouse model of spinal bulbar muscular atrophyPolyglutamine genes interact to modulate the severity and progression of neurodegeneration in Drosophila.Glial cell lineage expression of mutant ataxin-1 and huntingtin induces developmental and late-onset neuronal pathologies in Drosophila modelsGenes encoding novel secreted and transmembrane proteins are temporally and spatially regulated during Drosophila melanogaster embryogenesis.Loss of function of ATXN1 increases amyloid beta-protein levels by potentiating beta-secretase processing of beta-amyloid precursor protein.The histone deacetylase HDAC3 is essential for Purkinje cell function, potentially complicating the use of HDAC inhibitors in SCA1Androgen receptor and Kennedy disease/spinal bulbar muscular atrophyShared mechanisms between Drosophila peripheral nervous system development and human neurodegenerative diseasesA variant allele of Growth Factor Independence 1 (GFI1) is associated with acute myeloid leukemia.Broad therapeutic benefit after RNAi expression vector delivery to deep cerebellar nuclei: implications for spinocerebellar ataxia type 1 therapyRecovery of function in a myogenic mouse model of spinal bulbar muscular atrophy.Broad distribution of ataxin 1 silencing in rhesus cerebella for spinocerebellar ataxia type 1 therapy.Regional rescue of spinocerebellar ataxia type 1 phenotypes by 14-3-3epsilon haploinsufficiency in mice underscores complex pathogenicity in neurodegeneration
P2860
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P2860
The AXH domain of Ataxin-1 mediates neurodegeneration through its interaction with Gfi-1/Senseless proteins
description
2005 nî lūn-bûn
@nan
2005 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
The AXH domain of Ataxin-1 med ...... with Gfi-1/Senseless proteins
@ast
The AXH domain of Ataxin-1 med ...... with Gfi-1/Senseless proteins
@en
The AXH domain of Ataxin-1 med ...... with Gfi-1/Senseless proteins
@nl
type
label
The AXH domain of Ataxin-1 med ...... with Gfi-1/Senseless proteins
@ast
The AXH domain of Ataxin-1 med ...... with Gfi-1/Senseless proteins
@en
The AXH domain of Ataxin-1 med ...... with Gfi-1/Senseless proteins
@nl
prefLabel
The AXH domain of Ataxin-1 med ...... with Gfi-1/Senseless proteins
@ast
The AXH domain of Ataxin-1 med ...... with Gfi-1/Senseless proteins
@en
The AXH domain of Ataxin-1 med ...... with Gfi-1/Senseless proteins
@nl
P2093
P50
P3181
P1433
P1476
The AXH domain of Ataxin-1 med ...... with Gfi-1/Senseless proteins
@en
P2093
Akash J Patel
Hamed Jafar-Nejad
Hiroshi Tsuda
Juan Botas
Yaling Sun
P304
P3181
P356
10.1016/J.CELL.2005.06.012
P407
P577
2005-08-01T00:00:00Z