Partial loss of ataxin-1 function contributes to transcriptional dysregulation in spinocerebellar ataxia type 1 pathogenesis
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A multi-platform draft de novo genome assembly and comparative analysis for the Scarlet Macaw (Ara macao)Pharmacometabolomic signature of ataxia SCA1 mouse model and lithium effectsAtaxin-1 and Brother of ataxin-1 are components of the Notch signalling pathwayOf Fighting Flies, Mice, and Men: Are Some of the Molecular and Neuronal Mechanisms of Aggression Universal in the Animal Kingdom?Mouse models of polyglutamine diseases: review and data table. Part IBeyond the glutamine expansion: influence of posttranslational modifications of ataxin-1 in the pathogenesis of spinocerebellar ataxia type 1Ataxin-2 regulates RGS8 translation in a new BAC-SCA2 transgenic mouse modelProtein-protein interactions as a strategy towards protein-specific drug design: the example of ataxin-1Ataxin1L is a regulator of HSC function highlighting the utility of cross-tissue comparisons for gene discoveryATXN1 protein family and CIC regulate extracellular matrix remodeling and lung alveolarizationTargeting several CAG expansion diseases by a single antisense oligonucleotideGcn5 loss-of-function accelerates cerebellar and retinal degeneration in a SCA7 mouse model.Haploinsufficiency of two histone modifier genes on 6p22.3, ATXN1 and JARID2, is associated with intellectual disability.An out-of-frame overlapping reading frame in the ataxin-1 coding sequence encodes a novel ataxin-1 interacting proteinETS1 regulates the expression of ATXN2.Broad therapeutic benefit after RNAi expression vector delivery to deep cerebellar nuclei: implications for spinocerebellar ataxia type 1 therapyRequirement for zebrafish ataxin-7 in differentiation of photoreceptors and cerebellar neurons.Origins of context-dependent gene repression by capicua.Partial loss of Tip60 slows mid-stage neurodegeneration in a spinocerebellar ataxia type 1 (SCA1) mouse model.HMGB1 facilitates repair of mitochondrial DNA damage and extends the lifespan of mutant ataxin-1 knock-in mice.The role for alterations in neuronal activity in the pathogenesis of polyglutamine repeat disorders.Exercise and genetic rescue of SCA1 via the transcriptional repressor Capicua.The Capicua repressor--a general sensor of RTK signaling in development and disease.Deletions in chromosome 6p22.3-p24.3, including ATXN1, are associated with developmental delay and autism spectrum disordersAtaxin-1 poly(Q)-induced proteotoxic stress and apoptosis are attenuated in neural cells by docosahexaenoic acid-derived neuroprotectin D1.miR-93/miR-106b/miR-375-CIC-CRABP1: a novel regulatory axis in prostate cancer progressionThe importance of serine 776 in Ataxin-1 partner selection: a FRET analysis.Altered Purkinje cell miRNA expression and SCA1 pathogenesis.Polyglutamine disease toxicity is regulated by Nemo-like kinase in spinocerebellar ataxia type 1.Is SOD1 loss of function involved in amyotrophic lateral sclerosis?Homozygosity for the C9orf72 GGGGCC repeat expansion in frontotemporal dementia.Consensus paper: pathological mechanisms underlying neurodegeneration in spinocerebellar ataxias.Kaleidoscopic protein-protein interactions in the life and death of ataxin-1: new strategies against protein aggregation.Selection and Prioritization of Candidate Drug Targets for Amyotrophic Lateral Sclerosis Through a Meta-Analysis Approach.RNA therapy for polyglutamine neurodegenerative diseases.Alternative splicing in the C-terminal tail of Cav2.1 is essential for preventing a neurological disease in mice.Discovery of Therapeutic Approaches for Polyglutamine Diseases: A Summary of Recent Efforts.Modulation of Molecular Chaperones in Huntington's Disease and Other Polyglutamine Disorders.CIC inactivating mutations identify aggressive subset of 1p19q codeleted gliomas.A preliminary study on methylphenidate-regulated gene expression in lymphoblastoid cells of ADHD patients.
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P2860
Partial loss of ataxin-1 function contributes to transcriptional dysregulation in spinocerebellar ataxia type 1 pathogenesis
description
2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2010
@ast
im Juli 2010 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2010/07/08)
@sk
vědecký článek publikovaný v roce 2010
@cs
wetenschappelijk artikel (gepubliceerd op 2010/07/08)
@nl
наукова стаття, опублікована в липні 2010
@uk
مقالة علمية (نشرت في 8-7-2010)
@ar
name
Partial loss of ataxin-1 funct ...... lar ataxia type 1 pathogenesis
@ast
Partial loss of ataxin-1 funct ...... lar ataxia type 1 pathogenesis
@en
Partial loss of ataxin-1 funct ...... lar ataxia type 1 pathogenesis
@nl
type
label
Partial loss of ataxin-1 funct ...... lar ataxia type 1 pathogenesis
@ast
Partial loss of ataxin-1 funct ...... lar ataxia type 1 pathogenesis
@en
Partial loss of ataxin-1 funct ...... lar ataxia type 1 pathogenesis
@nl
prefLabel
Partial loss of ataxin-1 funct ...... lar ataxia type 1 pathogenesis
@ast
Partial loss of ataxin-1 funct ...... lar ataxia type 1 pathogenesis
@en
Partial loss of ataxin-1 funct ...... lar ataxia type 1 pathogenesis
@nl
P2093
P2860
P921
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P1476
Partial loss of ataxin-1 funct ...... lar ataxia type 1 pathogenesis
@en
P2093
Harry T. Orr
John D. Fryer
Juan Crespo-Barreto
P2860
P304
P356
10.1371/JOURNAL.PGEN.1001021
P5008
P577
2010-07-08T00:00:00Z