Structural insights into the editing of germ-line-encoded interactions between T-cell receptor and MHC class II by Vα CDR3
about
Structure-based design of altered MHC class II-restricted peptide ligands with heterogeneous immunogenicityEffect of CDR3 Sequences and Distal V Gene Residues in Regulating TCR-MHC Contacts and Ligand SpecificityT cell receptor bias for MHC: co-evolution or co-receptors?IMPIPS: the immune protection-inducing protein structure concept in the search for steric-electron and topochemical principles for complete fully-protective chemically synthesised vaccine developmentV genes in primates from whole genome sequencing data.How structural adaptability exists alongside HLA-A2 bias in the human αβ TCR repertoireElongated TCR alpha chain CDR3 favors an altered CD4 cytokine profile.Sequence and Structural Analyses Reveal Distinct and Highly Diverse Human CD8+ TCR Repertoires to Immunodominant Viral AntigensThe basis for limited specificity and MHC restriction in a T cell receptor interface.Plasticity in the contribution of T cell receptor variable region residues to binding of peptide-HLA-A2 complexes.Structure of Staphylococcal Enterotoxin E in Complex with TCR Defines the Role of TCR Loop Positioning in Superantigen Recognition.Structural interplay between germline interactions and adaptive recognition determines the bandwidth of TCR-peptide-MHC cross-reactivity.Differential utilization of binding loop flexibility in T cell receptor ligand selection and cross-reactivity.Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity.Structural and biophysical insights into the role of CD4 and CD8 in T cell activation.Duality of the murine CD8 compartment.Structural basis for self-recognition by autoimmune T-cell receptors.Conserved Vδ1 binding geometry in a setting of locus-disparate pHLA recognition by δ/αβTCRs: insight into recognition of HIV peptides by TCR.A guide to the effects of a large portion of the residues of triosephosphate isomerase on catalysis, stability, druggability, and human disease.Structural basis for clonal diversity of the human T cell response to a dominant influenza virus epitope.Changing the peptide specificity of a human T-cell receptor by directed evolution.An automated algorithm for extracting functional immunologic V-genes from genomes in jawed vertebrates.Emerging Concepts in TCR Specificity: Rationalizing and (Maybe) Predicting Outcomes.Human T cell receptor occurrence patterns encode immune history, genetic background, and receptor specificity
P2860
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P2860
Structural insights into the editing of germ-line-encoded interactions between T-cell receptor and MHC class II by Vα CDR3
description
2012 nî lūn-bûn
@nan
2012 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Structural insights into the e ...... or and MHC class II by Vα CDR3
@ast
Structural insights into the e ...... or and MHC class II by Vα CDR3
@en
Structural insights into the e ...... or and MHC class II by Vα CDR3
@nl
type
label
Structural insights into the e ...... or and MHC class II by Vα CDR3
@ast
Structural insights into the e ...... or and MHC class II by Vα CDR3
@en
Structural insights into the e ...... or and MHC class II by Vα CDR3
@nl
prefLabel
Structural insights into the e ...... or and MHC class II by Vα CDR3
@ast
Structural insights into the e ...... or and MHC class II by Vα CDR3
@en
Structural insights into the e ...... or and MHC class II by Vα CDR3
@nl
P2093
P2860
P3181
P356
P1476
Structural insights into the e ...... or and MHC class II by Vα CDR3
@en
P2093
Roy A Mariuzza
Suzanne L Topalian
P2860
P304
14960-14965
P3181
P356
10.1073/PNAS.1207186109
P407
P577
2012-08-28T00:00:00Z