Tyrosine 474 of ZAP-70 is required for association with the Shc adaptor and for T-cell antigen receptor-dependent gene activation

Tyrosine 474 of ZAP-70 is required for association with the Shc adaptor and for T-cell antigen receptor-dependent gene activation

Item
http://www.wikidata.org/entity/Q28278040
Tyrosine 319 in the interdomain B of ZAP-70 is a binding site for the Src homology 2 domain of LckBiochemical interactions integrating Itk with the T cell receptor-initiated signaling cascadeGRB2 Nucleates T Cell Receptor-Mediated LAT Clusters That Control PLC-γ1 Activation and Cytokine Production.ShcA regulates late stages of T cell development and peripheral CD4+ T cell numbers.Role of Shc in T-cell development and function.ShcA mediates the dominant pathway to extracellular signal-regulated kinase activation during early thymic developmentIntraflagellar transport is required for polarized recycling of the TCR/CD3 complex to the immune synapse.Cooperation and selectivity of the two Grb2 binding sites of p52Shc in T-cell antigen receptor signaling to Ras family GTPases and Myc-dependent survival.p66SHC promotes apoptosis and antagonizes mitogenic signaling in T cells.The p66Shc longevity gene is silenced through epigenetic modifications of an alternative promoter.Extensive temporally regulated reorganization of the lipid raft proteome following T-cell antigen receptor triggering.
P2860

Tyrosine 474 of ZAP-70 is required for association with the Shc adaptor and for T-cell antigen receptor-dependent gene activation

Item
http://www.wikidata.org/entity/Q28278040
description
1998 nî lūn-bûn
@nan
1998 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Tyrosine 474 of ZAP-70 is requ ...... ptor-dependent gene activation
@ast
Tyrosine 474 of ZAP-70 is requ ...... ptor-dependent gene activation
@en
Tyrosine 474 of ZAP-70 is requ ...... ptor-dependent gene activation
@nl
type
label
Tyrosine 474 of ZAP-70 is requ ...... ptor-dependent gene activation
@ast
Tyrosine 474 of ZAP-70 is requ ...... ptor-dependent gene activation
@en
Tyrosine 474 of ZAP-70 is requ ...... ptor-dependent gene activation
@nl
prefLabel
Tyrosine 474 of ZAP-70 is requ ...... ptor-dependent gene activation
@ast
Tyrosine 474 of ZAP-70 is requ ...... ptor-dependent gene activation
@en
Tyrosine 474 of ZAP-70 is requ ...... ptor-dependent gene activation
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698
P356
P1433
P1476
Tyrosine 474 of ZAP-70 is requ ...... ptor-dependent gene activation
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698