Transgenic mice that overexpress mouse apolipoprotein B. Evidence that the DNA sequences controlling intestinal expression of the apolipoprotein B gene are distant from the structural gene

Transgenic mice that overexpress mouse apolipoprotein B. Evidence that the DNA sequences controlling intestinal expression of the apolipoprotein B gene are distant from the structural gene

Item
http://www.wikidata.org/entity/Q28281569
A gene-targeted mouse model for familial hypobetalipoproteinemia. Low levels of apolipoprotein B mRNA in association with a nonsense mutation in exon 26 of the apolipoprotein B geneSusceptibility to atherosclerosis in mice expressing exclusively apolipoprotein B48 or apolipoprotein B100Dual mechanisms for the low plasma levels of truncated apolipoprotein B proteins in familial hypobetalipoproteinemia. Analysis of a new mouse model with a nonsense mutation in the Apob geneDefining the atherogenicity of large and small lipoproteins containing apolipoprotein B100Analysis of the role of microsomal triglyceride transfer protein in the liver of tissue-specific knockout mice.Deficiency of acyl CoA:cholesterol acyltransferase 2 prevents atherosclerosis in apolipoprotein E-deficient mice.Deficiency in Nrf2 transcription factor decreases adipose tissue mass and hepatic lipid accumulation in leptin-deficient miceEctopic expression of N-acetylglucosaminyltransferase III in transgenic hepatocytes disrupts apolipoprotein B secretion and induces aberrant cellular morphology with lipid storage.Knockout of the abetalipoproteinemia gene in mice: reduced lipoprotein secretion in heterozygotes and embryonic lethality in homozygotes.Delayed catabolism of apoB-48 lipoproteins due to decreased heparan sulfate proteoglycan production in diabetic miceBlocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice.Identification of the low density lipoprotein receptor-binding site in apolipoprotein B100 and the modulation of its binding activity by the carboxyl terminus in familial defective apo-B100.Identification of the principal proteoglycan-binding site in LDL. A single-point mutation in apo-B100 severely affects proteoglycan interaction without affecting LDL receptor binding.Immunochemical evidence that human apoB differs when expressed in rodent versus human cells.Absence of VLDL secretion does not affect alpha-tocopherol content in peripheral tissues.Apolipoprotein B gene expression in a series of human apolipoprotein B transgenic mice generated with recA-assisted restriction endonuclease cleavage-modified bacterial artificial chromosomes. An intestine-specific enhancer element is located betweeHuman apolipoprotein B transgenic mice generated with 207- and 145-kilobase pair bacterial artificial chromosomes. Evidence that a distant 5'-element confers appropriate transgene expression in the intestine.
P2860

Transgenic mice that overexpress mouse apolipoprotein B. Evidence that the DNA sequences controlling intestinal expression of the apolipoprotein B gene are distant from the structural gene

Item
http://www.wikidata.org/entity/Q28281569
description
1996 nî lūn-bûn
@nan
1996 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Transgenic mice that overexpre ...... stant from the structural gene
@ast
Transgenic mice that overexpre ...... stant from the structural gene
@en
Transgenic mice that overexpre ...... stant from the structural gene
@nl
type
label
Transgenic mice that overexpre ...... stant from the structural gene
@ast
Transgenic mice that overexpre ...... stant from the structural gene
@en
Transgenic mice that overexpre ...... stant from the structural gene
@nl
prefLabel
Transgenic mice that overexpre ...... stant from the structural gene
@ast
Transgenic mice that overexpre ...... stant from the structural gene
@en
Transgenic mice that overexpre ...... stant from the structural gene
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P5875
P698
P356
P1433
P1476
Transgenic mice that overexpre ...... stant from the structural gene
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P5875
P698