Transgenic mice containing a 248-kb yeast artificial chromosome carrying the human beta-globin locus display proper developmental control of human globin genes.
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{gamma}-Globin gene expression in chemical inducer of dimerization (CID)-dependent multipotential cells established from human {beta}-globin locus yeast artificial chromosome ({beta}-YAC) transgenic miceDifferential regulation of the human and murine CD34 genes in hematopoietic stem cells.Rapid isolation of yeast genomic DNA: Bust n' GrabExploiting genomics and natural genetic variation to decode macrophage enhancersAnimal models of β-hemoglobinopathies: utility and limitationsTransgenic mice that overexpress mouse apolipoprotein B. Evidence that the DNA sequences controlling intestinal expression of the apolipoprotein B gene are distant from the structural geneDevelopmental and species-divergent globin switching are driven by BCL11AA cell-based high-throughput screen for novel chemical inducers of fetal hemoglobin for treatment of hemoglobinopathiesEffect of deletion of 5'HS3 or 5'HS2 of the human beta-globin locus control region on the developmental regulation of globin gene expression in beta-globin locus yeast artificial chromosome transgenic mice.Fine tuning of globin gene expression by DNA methylation.Mutation of a transcriptional motif of a distant regulatory element reduces the expression of embryonic and fetal globin genes.Investigations of a human embryonic globin gene silencing element using YAC transgenic mice.Potential autoregulation of transcription factor PU.1 by an upstream regulatory elementGeneration of a genomic reporter assay system for analysis of γ- and β-globin gene regulation.Adult stage gamma-globin silencing is mediated by a promoter direct repeat element.Developmental specificity of the interaction between the locus control region and embryonic or fetal globin genes in transgenic mice with an HS3 core deletionSubstitution of the human beta-spectrin promoter for the human agamma-globin promoter prevents silencing of a linked human beta-globin gene in transgenic miceA zinc-finger transcriptional activator designed to interact with the gamma-globin gene promoters enhances fetal hemoglobin production in primary human adult erythroblastsMutagenesis of the human apolipoprotein B gene in a yeast artificial chromosome reveals the site of attachment for apolipoprotein(a)DNase I hypersensitivity and epsilon-globin transcriptional enhancement are separable in locus control region (LCR) HS1 mutant human beta-globin YAC transgenic miceTransgenic mice expressing high plasma concentrations of human apolipoprotein B100 and lipoprotein(a).Generation of a high-titer retroviral vector capable of expressing high levels of the human beta-globin gene.Genome architecture of the human beta-globin locus affects developmental regulation of gene expressionWidespread site-dependent buffering of human regulatory polymorphism.Use of yeast artificial chromosomes (YACs) in studies of mammalian development: production of beta-globin locus YAC mice carrying human globin developmental mutants.Modulation of fetal hemoglobin in sickle cell anemia.Promoters of the murine embryonic beta-like globin genes Ey and betah1 do not compete for interaction with the beta-globin locus control region.Phylogenetic comparisons suggest that distance from the locus control region guides developmental expression of primate beta-type globin genes.Human globin knock-in mice complete fetal-to-adult hemoglobin switching in postnatal developmentInappropriate splicing of a chimeric gene containing a large internal exon results in exon skipping in transgenic miceEvaluation of beta-globin gene therapy constructs in single copy transgenic mice.Position-independent expression of a human nerve growth factor-luciferase reporter gene cloned on a yeast artificial chromosome vector.Autonomous silencing as well as competition controls gamma-globin gene expression during development.Sequences in the (A)gamma-delta intergenic region are not required for stage-specific regulation of the human beta-globin gene locusTranscriptional regulation of fetal to adult hemoglobin switching: new therapeutic opportunities.A transient definitive erythroid lineage with unique regulation of the β-globin locus in the mammalian embryoThe FMR1 gene and fragile X-associated tremor/ataxia syndrome.Pharmacological induction of fetal hemoglobin synthesis using histone deacetylase inhibitors.A dominant chromatin-opening activity in 5' hypersensitive site 3 of the human beta-globin locus control region.Deletion of the core region of 5' HS2 of the mouse beta-globin locus control region reveals a distinct effect in comparison with human beta-globin transgenes
P2860
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P2860
Transgenic mice containing a 248-kb yeast artificial chromosome carrying the human beta-globin locus display proper developmental control of human globin genes.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年学术文章
@wuu
1993年学术文章
@zh-cn
1993年学术文章
@zh-hans
1993年学术文章
@zh-my
1993年学术文章
@zh-sg
1993年學術文章
@yue
1993年學術文章
@zh
1993年學術文章
@zh-hant
name
Transgenic mice containing a 2 ...... control of human globin genes.
@ast
Transgenic mice containing a 2 ...... control of human globin genes.
@en
type
label
Transgenic mice containing a 2 ...... control of human globin genes.
@ast
Transgenic mice containing a 2 ...... control of human globin genes.
@en
prefLabel
Transgenic mice containing a 2 ...... control of human globin genes.
@ast
Transgenic mice containing a 2 ...... control of human globin genes.
@en
P2093
P2860
P356
P1476
Transgenic mice containing a 2 ...... control of human globin genes.
@en
P2093
B M Josephson
G Stamatoyannopoulos
H S Haugen
K R Peterson
T Furukawa
P2860
P304
P356
10.1073/PNAS.90.16.7593
P407
P577
1993-08-01T00:00:00Z