Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G - Wikidata - wikimedia - TriplyDB

Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G

Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G

http://www.wikidata.org/entity/Q28285121

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Translational control in the stress adaptive response of cancer cells: a novel role for the heat shock protein TRAP1 Structural conservation of druggable hot spots in protein-protein interfaces Crystal structure of the yeast eIF4A-eIF4G complex: an RNA-helicase controlled by protein-protein interactions Dysregulation of Mammalian Target of Rapamycin Signaling in Mouse Models of Autism Milk--A Nutrient System of Mammalian Evolution Promoting mTORC1-Dependent Translation Targeting the PI3K/AKT/mTOR signaling axis in children with hematologic malignancies Features of protein-protein interactions that translate into potent inhibitors: topology, surface area and affinity Targeting translation initiation in breast cancer Structural Insights into Parasite eIF4E Binding Specificity for m7G and m2,2,7G mRNA Caps A Small-Molecule Inhibitor of BCL6 Kills DLBCL Cells In Vitro and In Vivo Comparative Structural Analysis of Human DEAD-Box RNA Helicases Improved eIF4E Binding Peptides by Phage Display Guided Design: Plasticity of Interacting Surfaces Yield Collective Effects Structural Insights into the Allosteric Effects of 4EBP1 on the Eukaryotic Translation Initiation Factor eIF4E Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G mTOR inhibitors in cancer therapy Regulation of translation initiation in eukaryotes: mechanisms and biological targets NUP98 dysregulation in myeloid leukemogenesis Nontoxic chemical interdiction of the epithelial-to-mesenchymal transition by targeting cap-dependent translation CPEB2-eEF2 interaction impedes HIF-1α RNA translation Targeting eukaryotic translation in mesothelioma cells with an eIF4E-specific antisense oligonucleotide Autism-related deficits via dysregulated eIF4E-dependent translational control.PI3K and cancer: lessons, challenges and opportunities Mycobacterium tuberculosis subverts negative regulatory pathways in human macrophages to drive immunopathology.Inhibition of the interactions between eukaryotic initiation factors 4E and 4G impairs long-term associative memory consolidation but not reconsolidation Temporal and spatial regulation of translation in the mammalian oocyte via the mTOR-eIF4F pathway Development of a high-throughput cell-based reporter assay to identify stabilizers of tumor suppressor Pdcd4.eIF4E: new family members, new binding partners, new roles.Design, synthesis and evaluation of analogs of initiation factor 4E (eIF4E) cap-binding antagonist Bn7-GMP SYK regulates mTOR signaling in AML.Autophagy is a signature of a signaling network that maintains hematopoietic stem cells Aberrations in translational regulation are associated with poor prognosis in hormone receptor-positive breast cancer Targeting the translational machinery as a novel treatment strategy for hematologic malignancies The eIF4E/eIF4G interaction inhibitor 4EGI-1 augments TRAIL-mediated apoptosis through c-FLIP Down-regulation and DR5 induction independent of inhibition of cap-dependent protein translation Over-expression of eukaryotic translation initiation factor 4 gamma 1 correlates with tumor progression and poor prognosis in nasopharyngeal carcinoma.Altered translation of GATA1 in Diamond-Blackfan anemia.Blocking eIF4E-eIF4G interaction as a strategy to impair coronavirus replication.A conserved structure within the HIV gag open reading frame that controls translation initiation directly recruits the 40S subunit and eIF3.Axonal cap-dependent translation regulates presynaptic p35.Flavaglines target primitive leukemia cells and enhance anti-leukemia drug activity.Sensitivity of global translation to mTOR inhibition in REN cells depends on the equilibrium between eIF4E and 4E-BP1.

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Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G

http://www.wikidata.org/entity/Q28285121

description

2007 nî lūn-bûn

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2007 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2007 թվականի հունվարին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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name

Small-molecule inhibition of t ...... iation factors eIF4E and eIF4G

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Small-molecule inhibition of t ...... iation factors eIF4E and eIF4G

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Small-molecule inhibition of t ...... iation factors eIF4E and eIF4G

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Small-molecule inhibition of t ...... iation factors eIF4E and eIF4G

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Small-molecule inhibition of t ...... iation factors eIF4E and eIF4G

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Small-molecule inhibition of t ...... iation factors eIF4E and eIF4G

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Amr Fahmy

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10.1016/J.CELL.2006.11.046

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Mikhail Reibarkh

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