RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion
about
Krit 1 interactions with microtubules and membranes are regulated by Rap1 and integrin cytoplasmic domain associated protein-1KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progressionLocal activation of Rap1 contributes to directional vascular endothelial cell migration accompanied by extension of microtubules on which RAPL, a Rap1-associating molecule, localizesEndophilin, Lamellipodin, and Mena cooperate to regulate F-actin-dependent EGF-receptor endocytosis.RIAM regulates the cytoskeletal distribution and activation of PLC-gamma1 in T cellsProfilin1 regulates PI(3,4)P2 and lamellipodin accumulation at the leading edge thus influencing motility of MDA-MB-231 cellsG protein betagamma subunits regulate cell adhesion through Rap1a and its effector RadilRap1a is a key regulator of fibroblast growth factor 2-induced angiogenesis and together with Rap1b controls human endothelial cell functionsRIAM activates integrins by linking talin to ras GTPase membrane-targeting sequencesClustering of VASP actively drives processive, WH2 domain-mediated actin filament elongation.Specificity in Ras and Rap signalingT cell activationThe ADAP/SKAP55 signaling module regulates T-cell receptor-mediated integrin activation through plasma membrane targeting of Rap1The M-Ras-RA-GEF-2-Rap1 pathway mediates tumor necrosis factor-alpha dependent regulation of integrin activation in splenocytesPI3K regulates pleckstrin-2 in T-cell cytoskeletal reorganization.Ubiquitination of the GTPase Rap1B by the ubiquitin ligase Smurf2 is required for the establishment of neuronal polarityMoving towards a paradigm: common mechanisms of chemotactic signaling in Dictyostelium and mammalian leukocytesRole of guanine-nucleotide exchange factor Epac in renal physiology and pathophysiologyMolecular insights on context-specific role of profilin-1 in cell migrationRap1 can bypass the FAK-Src-Paxillin cascade to induce cell spreading and focal adhesion formationVinculin controls talin engagement with the actomyosin machinery.Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14Rap1-interacting adapter molecule (RIAM) associates with the plasma membrane via a proximity detectorRIAM and Vinculin Binding to Talin Are Mutually Exclusive and Regulate Adhesion Assembly and TurnoverCrystal structure of Lamellipodin implicates diverse functions in actin polymerization and Ras signalingStructural Basis for the Interaction of the Adaptor Protein Grb14 with Activated RasThe structure of Rap1 in complex with RIAM reveals specificity determinants and recruitment mechanismRole of an imbalanced miRNAs axis in pathogenesis of psoriasis: novel perspectives based on review of the literatureMultiple roles of Rap1 in hematopoietic cells: complementary versus antagonistic functionsPREL1 provides a link from Ras signalling to the actin cytoskeleton via Ena/VASP proteinsRap1 activation is required for Fc gamma receptor-dependent phagocytosisc-Abl, Lamellipodin, and Ena/VASP proteins cooperate in dorsal ruffling of fibroblasts and axonal morphogenesisRIAM links the ADAP/SKAP-55 signaling module to Rap1, facilitating T-cell-receptor-mediated integrin activationDifferent levels of the Tripartite motif protein, Anomalies in sensory axon patterning (Asap), regulate distinct axonal projections of Drosophila sensory neuronsThe N terminus of SKAP55 enables T cell adhesion to TCR and integrin ligands via distinct mechanisms.Abelson interactor-1 (ABI-1) interacts with MRL adaptor protein MIG-10 and is required in guided cell migrations and process outgrowth in C. elegans.ADAP is required for normal alphaIIbbeta3 activation by VWF/GP Ib-IX-V and other agonists.A RIAM/lamellipodin-talin-integrin complex forms the tip of sticky fingers that guide cell migrationAn experimentally derived database of candidate Ras-interacting proteins.Rap1 activation in collagen phagocytosis is dependent on nonmuscle myosin II-A.
P2860
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P2860
RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion
description
2004 nî lūn-bûn
@nan
2004 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
RIAM, an Ena/VASP and Profilin ...... mediates Rap1-induced adhesion
@ast
RIAM, an Ena/VASP and Profilin ...... mediates Rap1-induced adhesion
@en
RIAM, an Ena/VASP and Profilin ...... mediates Rap1-induced adhesion
@nl
type
label
RIAM, an Ena/VASP and Profilin ...... mediates Rap1-induced adhesion
@ast
RIAM, an Ena/VASP and Profilin ...... mediates Rap1-induced adhesion
@en
RIAM, an Ena/VASP and Profilin ...... mediates Rap1-induced adhesion
@nl
prefLabel
RIAM, an Ena/VASP and Profilin ...... mediates Rap1-induced adhesion
@ast
RIAM, an Ena/VASP and Profilin ...... mediates Rap1-induced adhesion
@en
RIAM, an Ena/VASP and Profilin ...... mediates Rap1-induced adhesion
@nl
P2093
P50
P1433
P1476
RIAM, an Ena/VASP and Profilin ...... mediates Rap1-induced adhesion
@en
P2093
Alla Berezovskaya
André A F L van Puijenbroek
Erica Constantine
Frank B Gertler
Gordon J Freeman
Timothy A Springer
Vassiliki A Boussiotis
P304
P356
10.1016/J.DEVCEL.2004.07.021
P407
P577
2004-10-01T00:00:00Z