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The interaction of p53 with replication protein A mediates suppression of homologous recombination

The interaction of p53 with replication protein A mediates suppression of homologous recombination

http://www.wikidata.org/entity/Q28288360

about

Tensor GSVD of patient- and platform-matched tumor and normal DNA copy-number profiles uncovers chromosome arm-wide patterns of tumor-exclusive platform-consistent alterations encoding for cell transformation and predicting ovarian cancer survival Threshold effects of nitric oxide-induced toxicity and cellular responses in wild-type and p53-null human lymphoblastoid cells Gene conversion and deletion frequencies during double-strand break repair in human cells are controlled by the distance between direct repeats Involvement of p53 in the repair of DNA double strand breaks: multifaceted Roles of p53 in homologous recombination repair (HRR) and non-homologous end joining (NHEJ)Acetylation of lysine 382 and phosphorylation of serine 392 in p53 modulate the interaction between p53 and MDC1 in vitro p53 in the DNA-Damage-Repair Process Regulation of DNA double-strand break repair pathway choice Adaptive patterns in the p53 protein sequence of the hypoxia- and cancer-tolerant blind mole rat Spalax Single-stranded DNA mimicry in the p53 transactivation domain interaction with replication protein A ATR-p53 restricts homologous recombination in response to replicative stress but does not limit DNA interstrand crosslink repair in lung cancer cells.Small molecule inhibitor of the RPA70 N-terminal protein interaction domain discovered using in silico and in vitro methods.Mapping the physical and functional interactions between the tumor suppressors p53 and BRCA2.p53 at a glance.DNA-PK phosphorylation of RPA32 Ser4/Ser8 regulates replication stress checkpoint activation, fork restart, homologous recombination and mitotic catastrophe.p53 Ser15 phosphorylation disrupts the p53-RPA70 complex and induces RPA70-mediated DNA repair in hypoxia.DNA-PK, ATM and ATR collaboratively regulate p53-RPA interaction to facilitate homologous recombination DNA repair A small molecule directly inhibits the p53 transactivation domain from binding to replication protein A.p53 isoform Δ113p53/Δ133p53 promotes DNA double-strand break repair to protect cell from death and senescence in response to DNA damage p53 null fluorescent yellow direct repeat (FYDR) mice have normal levels of homologous recombination p53 mediates senescence-like arrest induced by chronic replicational stress DNA damage tolerance pathway involving DNA polymerase ι and the tumor suppressor p53 regulates DNA replication fork progression.Influence of Human p53 on Plant Development.Knockin mice expressing a chimeric p53 protein reveal mechanistic differences in how p53 triggers apoptosis and senescence.hSSB1 regulates both the stability and the transcriptional activity of p53 A role for the p53 tumour suppressor in regulating the balance between homologous recombination and non-homologous end joining.The relevance of protein-protein interactions for p53 function: the CPE contribution.E2F-7 couples DNA damage-dependent transcription with the DNA repair process.p53 modulates homologous recombination at I-SceI-induced double-strand breaks through cell-cycle regulation.p53 modulates homologous recombination by transcriptional regulation of the RAD51 gene.Bridge-Induced Translocation between NUP145 and TOP2 Yeast Genes Models the Genetic Fusion between the Human Orthologs Associated With Acute Myeloid Leukemia.Dissecting the role of p53 phosphorylation in homologous recombination provides new clues for gain-of-function mutants.p53 orchestrates DNA replication restart homeostasis by suppressing mutagenic RAD52 and POLθ pathways.p53 suppresses BRCA2-stimulated ATPase and strand exchange functions of human RAD51.A new role for a tumor-suppressing protein.Transcriptional activation of p21Waf1 contributes to suppression of HR by p53 in response to replication arrest induced by camptothecin.

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P2860

The interaction of p53 with replication protein A mediates suppression of homologous recombination

http://www.wikidata.org/entity/Q28288360

description

2004 nî lūn-bûn

@nan

2004 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2004 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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The interaction of p53 with re ...... on of homologous recombination

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The interaction of p53 with re ...... on of homologous recombination

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The interaction of p53 with re ...... on of homologous recombination

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Henning Willers

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Larisa Y Romanova

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Simon N Powell

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P2860

Replication Protein A (RPA): The Eukaryotic SSB

Interaction of p53 with the human Rad51 protein

Physical interaction between human RAD52 and RPA is required for homologous recombination in mammalian cells

Structure of the single-stranded-DNA-binding domain of replication protein A bound to DNA

Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining

Recombinational DNA Repair in Cancer and Normal Cells: The Challenge of Functional Analysis

p53, the cellular gatekeeper for growth and division

A hierarchy of SSB protomers in replication protein A.

Double-strand break repair in yeast requires both leading and lagging strand DNA polymerases.

The processing of Holliday junctions by BLM and WRN helicases is regulated by p53

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scholarly article

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3452419

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10.1038/SJ.ONC.1207982

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23

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Mikhail Blagosklonny

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2004-12-02T00:00:00Z

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8226755

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1013721501

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