Lymphocyte transformation by Pim-2 is dependent on nuclear factor-kappaB activation
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Pim-2 phosphorylation of p21(Cip1/WAF1) enhances its stability and inhibits cell proliferation in HCT116 cellsEmerging roles for the non-canonical IKKs in cancerTargeting the Pim kinases in multiple myelomaThe PIM kinases in hematological cancersPim-1 controls NF-kappaB signalling by stabilizing RelA/p65Proviral integration site for Moloney murine leukemia virus (PIM) kinases promote human T helper 1 cell differentiationTranscriptional networks in plasmacytoid dendritic cells stimulated with synthetic TLR 7 agonistsRNAi screen identifies a synthetic lethal interaction between PIM1 overexpression and PLK1 inhibitionEctopic over-expression of oncogene Pim-2 induce malignant transformation of nontumorous human liver cell line L02Activation of cell cycle arrest and apoptosis by the proto-oncogene Pim-2.The NF-kappaB activation pathways, emerging molecular targets for cancer prevention and therapyThe over-expression of Pim-2 promote the tumorigenesis of prostatic carcinoma through phosphorylating eIF4B.Human CD180 Transmits Signals via the PIM-1L Kinase.PIM kinases are progression markers and emerging therapeutic targets in diffuse large B-cell lymphoma.The survival kinases Akt and Pim as potential pharmacological targets.Multiple signaling pathways promote B lymphocyte stimulator dependent B-cell growth and survival.Why target PIM1 for cancer diagnosis and treatment?PIM kinases: an overview in tumors and recent advances in pancreatic cancer.Pim kinases in hematological malignancies: where are we now and where are we going?Elevated PIM2 gene expression is associated with poor survival of patients with acute myeloid leukemia.Loss of PIM2 enhances the anti-proliferative effect of the pan-PIM kinase inhibitor AZD1208 in non-Hodgkin lymphomas.Pim-2 Modulates Aerobic Glycolysis and Energy Production during the Development of Colorectal TumorsInhibition of PIM1 kinase attenuates inflammation-induced pro-labour mediators in human foetal membranes in vitro.Expression and significance of Pim-3 kinase in adult T-cell leukemia.The PIM-2 kinase is an essential component of the ultraviolet damage response that acts upstream to E2F-1 and ATMTranscription and translation are primary targets of Pim kinase inhibitor SGI-1776 in mantle cell lymphoma.Novel benzylidene-thiazolidine-2,4-diones inhibit Pim protein kinase activity and induce cell cycle arrest in leukemia and prostate cancer cellsThe PIM1 kinase is a critical component of a survival pathway activated by docetaxel and promotes survival of docetaxel-treated prostate cancer cells.Novel inhibition of PIM2 kinase has significant anti-tumor efficacy in multiple myeloma.The PIM family of oncoproteins: small kinases with huge implications in myeloid leukemogenesis and as therapeutic targets.Pim and Akt oncogenes are independent regulators of hematopoietic cell growth and survival.Bcl-2 blocks 2-methoxyestradiol induced leukemia cell apoptosis by a p27(Kip1)-dependent G1/S cell cycle arrest in conjunction with NF-kappaB activation.Accelerated hepatocellular carcinoma development in mice expressing the Pim-3 transgene selectively in the liver.Identification of Upstream Kinases by Fluorescence Complementation Mass Spectrometry.Gene expression signatures separate B-cell chronic lymphocytic leukaemia prognostic subgroups defined by ZAP-70 and CD38 expression status.Downregulation of Pim-2 induces cell cycle arrest in the G0/G1 phase via the p53-non-dependent p21 signaling pathway.Pim-2 is a critical target for treatment of osteoclastogenesis enhanced in myeloma.Proviral integration site 2 is required for interleukin-6 expression induced by interleukin-1, tumour necrosis factor-α and lipopolysaccharide.
P2860
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P2860
Lymphocyte transformation by Pim-2 is dependent on nuclear factor-kappaB activation
description
2004 nî lūn-bûn
@nan
2004 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Lymphocyte transformation by Pim-2 is dependent on nuclear factor-kappaB activation
@ast
Lymphocyte transformation by Pim-2 is dependent on nuclear factor-kappaB activation
@en
Lymphocyte transformation by Pim-2 is dependent on nuclear factor-kappaB activation
@nl
type
label
Lymphocyte transformation by Pim-2 is dependent on nuclear factor-kappaB activation
@ast
Lymphocyte transformation by Pim-2 is dependent on nuclear factor-kappaB activation
@en
Lymphocyte transformation by Pim-2 is dependent on nuclear factor-kappaB activation
@nl
prefLabel
Lymphocyte transformation by Pim-2 is dependent on nuclear factor-kappaB activation
@ast
Lymphocyte transformation by Pim-2 is dependent on nuclear factor-kappaB activation
@en
Lymphocyte transformation by Pim-2 is dependent on nuclear factor-kappaB activation
@nl
P2093
P1433
P1476
Lymphocyte transformation by Pim-2 is dependent on nuclear factor-kappaB activation
@en
P2093
Casey J Fox
Craig B Thompson
John D Wagner
Peter S Hammerman
Ryan M Cinalli
Tullia Lindsten
P304
P356
10.1158/0008-5472.CAN-04-2284
P407
P577
2004-11-15T00:00:00Z