Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein
about
P1343
cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolismTopological analysis of Niemann-Pick C1 protein reveals that the membrane orientation of the putative sterol-sensing domain is identical to those of 3-hydroxy-3-methylglutaryl-CoA reductase and sterol regulatory element binding protein cleavage-actiDirect binding of DNA by tumor suppressor meninThe hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8Identification of complexes between the COOH-terminal domains of sterol regulatory element-binding proteins (SREBPs) and SREBP cleavage-activating proteinThree mutations in sterol-sensing domain of SCAP block interaction with insig and render SREBP cleavage insensitive to sterols.Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesisSynergistic cooperation of TFE3 and smad proteins in TGF-beta-induced transcription of the plasminogen activator inhibitor-1 geneA proteolytic pathway that controls the cholesterol content of membranes, cells, and bloodCholesterol feedback: from Schoenheimer's bottle to Scap's MELADLA conserved ER targeting motif in three families of lipid binding proteins and in Opi1p binds VAPHepatic cholesterol metabolism and resistance to dietary cholesterol in LXRbeta-deficient miceInsig-1 "brakes" lipogenesis in adipocytes and inhibits differentiation of preadipocytesDual functions of Insig proteins in cholesterol homeostasisThe combined hyperlipidemia caused by impaired Wnt-LRP6 signaling is reversed by Wnt3a rescueA century of cholesterol and coronaries: from plaques to genes to statinsHuman acyl-CoA:cholesterol acyltransferase-1 (ACAT-1) gene organization and evidence that the 4.3-kilobase ACAT-1 mRNA is produced from two different chromosomesReconstitution of sterol-regulated endoplasmic reticulum-to-Golgi transport of SREBP-2 in insect cells by co-expression of mammalian SCAP and InsigsMembrane topology of human insig-1, a protein regulator of lipid synthesisThe luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the GolgiInsig-dependent ubiquitination and degradation of 3-hydroxy-3-methylglutaryl coenzyme a reductase stimulated by delta- and gamma-tocotrienolsIsolation of mutant cells lacking Insig-1 through selection with SR-12813, an agent that stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductaseAsparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by site-2 proteaseSREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevationTumor suppressor menin regulates expression of insulin-like growth factor binding protein 2Menin induces apoptosis in murine embryonic fibroblastsMaintaining cholesterol homeostasis: sterol regulatory element-binding proteinsCleavage of sterol regulatory element-binding proteins (SREBPs) at site-1 requires interaction with SREBP cleavage-activating protein. Evidence from in vivo competition studiesSREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liverPROTEIN STRUCTURE. Crystal structure of a mycobacterial Insig homolog provides insight into how these sensors monitor sterol levels.The gene-gene interaction of INSIG-SCAP-SREBP pathway on the risk of obesity in Chinese children.Altered binding of mutated presenilin with cytoskeleton-interacting proteins.Automated microscopy screening for compounds that partially revert cholesterol accumulation in Niemann-Pick C cells.Clues to neuro-degeneration in Niemann-Pick type C disease from global gene expression profilingIdentification of novel genes and pathways regulating SREBP transcriptional activityDevelopment of an accurate classification system of proteins into structured and unstructured regions that uncovers novel structural domains: its application to human transcription factors.Sterol regulatory element-binding proteins are regulators of the NIS gene in thyroid cells.Transcriptional control of hepatic lipid metabolism by SREBP and ChREBP.Site-1 protease is required for cartilage development in zebrafish.Cholesterol binding, efflux, and a PDZ-interacting domain of scavenger receptor-BI mediate HDL-initiated signaling.
P2860
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P2860
Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein
description
1996 nî lūn-bûn
@nan
1996 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Sterol resistance in CHO cells ...... BP cleavage-activating protein
@ast
Sterol resistance in CHO cells ...... BP cleavage-activating protein
@en
Sterol resistance in CHO cells ...... BP cleavage-activating protein
@nl
type
label
Sterol resistance in CHO cells ...... BP cleavage-activating protein
@ast
Sterol resistance in CHO cells ...... BP cleavage-activating protein
@en
Sterol resistance in CHO cells ...... BP cleavage-activating protein
@nl
prefLabel
Sterol resistance in CHO cells ...... BP cleavage-activating protein
@ast
Sterol resistance in CHO cells ...... BP cleavage-activating protein
@en
Sterol resistance in CHO cells ...... BP cleavage-activating protein
@nl
P2093
P3181
P1433
P1476
Sterol resistance in CHO cells ...... BP cleavage-activating protein
@en
P2093
P304
P3181
P356
10.1016/S0092-8674(00)81362-8
P407
P4510
P577
1996-11-01T00:00:00Z