Membrane topology of human insig-1, a protein regulator of lipid synthesis
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Sterol-regulated degradation of Insig-1 mediated by the membrane-bound ubiquitin ligase gp78Membrane topology of human NPC1L1, a key protein in enterohepatic cholesterol absorptionProteasomal degradation of ubiquitinated Insig proteins is determined by serine residues flanking ubiquitinated lysinesJuxtamembranous aspartic acid in Insig-1 and Insig-2 is required for cholesterol homeostasisOverexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesisUnsaturated fatty acids inhibit proteasomal degradation of Insig-1 at a postubiquitination stepSterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to InsigInverting the Topology of a Transmembrane Protein by Regulating the Translocation of the First Transmembrane HelixIsolation of mutant cells lacking Insig-1 through selection with SR-12813, an agent that stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductaseStructural insights into triglyceride storage mediated by fat storage-inducing transmembrane (FIT) protein 2PROTEIN STRUCTURE. Crystal structure of a mycobacterial Insig homolog provides insight into how these sensors monitor sterol levels.Targeting of neutral cholesterol ester hydrolase to the endoplasmic reticulum via its N-terminal sequence.Evidence that the COOH terminus of human presenilin 1 is located in extracytoplasmic space.Mitsugumin 23 forms a massive bowl-shaped assembly and cation-conducting channelThyroid-stimulating hormone decreases HMG-CoA reductase phosphorylation via AMP-activated protein kinase in the liver.The Regulatory Domain of Squalene Monooxygenase Contains a Re-entrant Loop and Senses Cholesterol via a Conformational Change.Ancient ubiquitous protein-1 mediates sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl CoA reductase in lipid droplet-associated endoplasmic reticulum membranes.Cholesterol: from feeding to gene regulation.Lipid-regulated degradation of HMG-CoA reductase and Insig-1 through distinct mechanisms in insect cells.Tsc10p and FVT1: topologically distinct short-chain reductases required for long-chain base synthesis in yeast and mammals.Regulated endoplasmic reticulum-associated degradation of a polytopic protein: p97 recruits proteasomes to Insig-1 before extraction from membranesIntramembrane glycine mediates multimerization of Insig-2, a requirement for sterol regulation in Chinese hamster ovary cells.DHCR24 associates strongly with the endoplasmic reticulum beyond predicted membrane domains: implications for the activities of this multi-functional enzyme.Sterols and sphingolipids: dynamic duo or partners in crime?Regulation of cholesterol and fatty acid synthesis.The mechanistic basis for the induction of hepatic steatosis by xenobiotics.Retrospective on Cholesterol Homeostasis: The Central Role of Scap.Hypoxia-inducible factor 1α activates insulin-induced gene 2 (Insig-2) transcription for degradation of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase in the liver.Targeting mitochondrial 18 kDa translocator protein (TSPO) regulates macrophage cholesterol efflux and lipid phenotype.Dislocation of HMG-CoA reductase and Insig-1, two polytopic endoplasmic reticulum proteins, en route to proteasomal degradation.Isolation of sterol-resistant Chinese hamster ovary cells with genetic deficiencies in both Insig-1 and Insig-2.Insig regulates HMG-CoA reductase by controlling enzyme phosphorylation in fission yeastDegradation of HMG-CoA reductase in rat liver is cholesterol and ubiquitin independent.The active site His-460 of human acyl-coenzyme A:cholesterol acyltransferase 1 resides in a hitherto undisclosed transmembrane domain.INSIG2 polymorphism and weight gain, dyslipidemia and serum adiponectin in Finnish patients with schizophrenia treated with clozapine.Contribution of presenilin transmembrane domains 6 and 7 to a water-containing cavity in the gamma-secretase complex.Carboxyl-terminal Tail-mediated Homodimerizations of Sphingomyelin Synthases Are Responsible for Efficient Export from the Endoplasmic Reticulum.Thyroid hormone responsive protein spot 14 enhances lipogenesis in bovine mammary epithelial cells.
P2860
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P2860
Membrane topology of human insig-1, a protein regulator of lipid synthesis
description
2004 nî lūn-bûn
@nan
2004 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Membrane topology of human insig-1, a protein regulator of lipid synthesis
@ast
Membrane topology of human insig-1, a protein regulator of lipid synthesis
@en
Membrane topology of human insig-1, a protein regulator of lipid synthesis
@nl
type
label
Membrane topology of human insig-1, a protein regulator of lipid synthesis
@ast
Membrane topology of human insig-1, a protein regulator of lipid synthesis
@en
Membrane topology of human insig-1, a protein regulator of lipid synthesis
@nl
prefLabel
Membrane topology of human insig-1, a protein regulator of lipid synthesis
@ast
Membrane topology of human insig-1, a protein regulator of lipid synthesis
@en
Membrane topology of human insig-1, a protein regulator of lipid synthesis
@nl
P2860
P356
P1476
Membrane topology of human insig-1, a protein regulator of lipid synthesis
@en
P2093
Jamison D Feramisco
Michael S Brown
P2860
P304
P356
10.1074/JBC.M312623200
P407
P577
2004-02-27T00:00:00Z