Localization of the APECED protein in distinct nuclear structures
about
The many faces of aire in central toleranceExpression of the autoimmune regulator gene and its relevance to the mechanisms of central and peripheral toleranceSubcellular localization of the autoimmune regulator protein. characterization of nuclear targeting and transcriptional activation domainThe autoimmune regulator (AIRE) is a DNA-binding proteinThe von Hippel-Lindau tumor suppressor stabilizes novel plant homeodomain protein Jade-1Mutations in the AIRE gene: effects on subcellular location and transactivation function of the autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy proteinAire and T cell developmentTranscriptional regulation by AIRE: molecular mechanisms of central toleranceAutoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED): a model disease to study molecular aspects of endocrine autoimmunityUbiquitin in the immune systemThe autoimmune regulator protein has transcriptional transactivating properties and interacts with the common coactivator CREB-binding proteinAPECED mutations in the autoimmune regulator (AIRE) geneModulation of Aire regulates the expression of tissue-restricted antigensAire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-toleranceSubcellular location and expression pattern of autoimmune regulator (Aire), the mouse orthologue for human gene defective in autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED)Cloning of the APECED gene provides new insight into human autoimmunity.Clues to immune tolerance: the monogenic autoimmune syndromesAddressing protein localization within the nucleus.Autoimmune regulator: from loss of function to autoimmunity.Patient mutation in AIRE disrupts P-TEFb binding and target gene transcription.ATR-X mutations cause impaired nuclear location and altered DNA binding properties of the XNP/ATR-X proteinGenetic lesions in T-cell tolerance and thresholds for autoimmunity.AIRE and APECED: molecular insights into an autoimmune disease.AIRE functions as an E3 ubiquitin ligaseGene dosage--limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity.Hyposplenism: a comprehensive review. Part I: basic concepts and causes.Human APECED; a Sick Thymus Syndrome?Monogenic autoimmune diseases: insights into self-tolerance.AIRE in the thymus and beyond.Models of aire-dependent gene regulation for thymic negative selection.The role of ubiquitin ligases in the control of organ specific autoimmunity.Characterization of regulatory elements and methylation pattern of the autoimmune regulator (AIRE) promoter.AIRE: From promiscuous molecular partnerships to promiscuous gene expression.FBXO3 Protein Promotes Ubiquitylation and Transcriptional Activity of AIRE (Autoimmune Regulator)AIRE recruits P-TEFb for transcriptional elongation of target genes in medullary thymic epithelial cells.The transcriptional regulator Aire binds to and activates super-enhancers.Subcellular expression of autoimmune regulator is organized in a spatiotemporal manner.[Heterogeneity of type 1 diabetes mellitus].No significant association between mutations in exons 6 and 8 of the autoimmune regulator (AIRE) gene and inflammatory bowel disease.Update on Aire and thymic negative selection.
P2860
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P2860
Localization of the APECED protein in distinct nuclear structures
description
1999 nî lūn-bûn
@nan
1999 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Localization of the APECED protein in distinct nuclear structures
@ast
Localization of the APECED protein in distinct nuclear structures
@en
Localization of the APECED protein in distinct nuclear structures
@nl
type
label
Localization of the APECED protein in distinct nuclear structures
@ast
Localization of the APECED protein in distinct nuclear structures
@en
Localization of the APECED protein in distinct nuclear structures
@nl
prefLabel
Localization of the APECED protein in distinct nuclear structures
@ast
Localization of the APECED protein in distinct nuclear structures
@en
Localization of the APECED protein in distinct nuclear structures
@nl
P2093
P356
P1476
Localization of the APECED protein in distinct nuclear structures
@en
P2093
J Aaltonen
J Kaukonen
L Peltonen
M Pelto-Huikko
P304
P356
10.1093/HMG/8.2.259
P407
P577
1999-02-01T00:00:00Z