Novel nonpeptide agents potently block the C-type inactivated conformation of Kv1.3 and suppress T cell activation
about
Clofazimine inhibits human Kv1.3 potassium channel by perturbing calcium oscillation in T lymphocytesA nongenomic mechanism for progesterone-mediated immunosuppression: inhibition of K+ channels, Ca2+ signaling, and gene expression in T lymphocytesK+ channels as targets for specific immunomodulationA whole-genome RNAi screen uncovers a novel role for human potassium channels in cell killing by the parasite Entamoeba histolyticaOrai1 and STIM1 move to the immunological synapse and are up-regulated during T cell activation.Expression and function of a CP339,818-sensitive K⁺ current in a subpopulation of putative nociceptive neurons from adult mouse trigeminal ganglia.Loureirin B, an essential component of Sanguis Draxonis, inhibits Kv1.3 channel and suppresses cytokine release from Jurkat T cellsThe Lymphocyte Potassium Channels Kv1.3 and KCa3.1 as Targets for Immunosuppression.Kv1 channels and neural processing in vestibular calyx afferents.Use of Kv1.3 blockers for inflammatory skin conditions.Pyramidal neurons in the superficial layers of rat retrosplenial cortex exhibit a late-spiking firing propertyAltered potassium channel distribution and composition in myelinated axons suppresses hyperexcitability following injury.Synthesis and evaluation of a 125I-labeled iminodihydroquinoline-derived tracer for imaging of voltage-gated sodium channels.The functional network of ion channels in T lymphocytesHCN Channels Modulators: The Need for Selectivity.New Trends in Cancer Therapy: Targeting Ion Channels and Transporters.Molecular determinants of the inhibition of human Kv1.5 potassium currents by external protons and Zn(2+).Sulfonium salts as leaving groups for aromatic labelling of drug-like small molecules with fluorine-18.Regulation of mammalian Shaker-related K+ channels: evidence for non-conducting closed and non-conducting inactivated states.Spiro azepane-oxazolidinones as Kv1.3 potassium channel blockers: WO2010066840.Differential responses of rabbit ventricular and atrial transient outward current (Ito) to the Ito modulator NS5806.State-dependent blocking mechanism of Kv 1.3 channels by the antimycobacterial drug clofazimine.Calcium-activated and voltage-gated potassium channels of the pancreatic islet impart distinct and complementary roles during secretagogue induced electrical responses.UK-78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage-gated potassium channel and inhibits human T cell activation.The differential expression of low-threshold K+ currents generates distinct firing patterns in different subtypes of adult mouse trigeminal ganglion neurones.Initial segment Kv2.2 channels mediate a slow delayed rectifier and maintain high frequency action potential firing in medial nucleus of the trapezoid body neurons.
P2860
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P2860
Novel nonpeptide agents potently block the C-type inactivated conformation of Kv1.3 and suppress T cell activation
description
1996 nî lūn-bûn
@nan
1996 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Novel nonpeptide agents potent ...... and suppress T cell activation
@ast
Novel nonpeptide agents potent ...... and suppress T cell activation
@en
Novel nonpeptide agents potent ...... and suppress T cell activation
@nl
type
label
Novel nonpeptide agents potent ...... and suppress T cell activation
@ast
Novel nonpeptide agents potent ...... and suppress T cell activation
@en
Novel nonpeptide agents potent ...... and suppress T cell activation
@nl
prefLabel
Novel nonpeptide agents potent ...... and suppress T cell activation
@ast
Novel nonpeptide agents potent ...... and suppress T cell activation
@en
Novel nonpeptide agents potent ...... and suppress T cell activation
@nl
P2093
P1476
Novel nonpeptide agents potent ...... and suppress T cell activation
@en
P2093
Biggers MS
Cahalan MD
Canniff PC
Donovan CB
Grissmer S
P304
P407
P577
1996-12-01T00:00:00Z