UK-78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage-gated potassium channel and inhibits human T cell activation.
about
Clofazimine inhibits human Kv1.3 potassium channel by perturbing calcium oscillation in T lymphocytesK+ channels as targets for specific immunomodulationTargeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseasesThe antibody targeting the E314 peptide of human Kv1.3 pore region serves as a novel, potent and specific channel blockerThe Lymphocyte Potassium Channels Kv1.3 and KCa3.1 as Targets for Immunosuppression.Use of Kv1.3 blockers for inflammatory skin conditions.Voltage-gated potassium channels as therapeutic targets.Kv1.3 potassium channels as a therapeutic target in multiple sclerosis.The functional network of ion channels in T lymphocytesPharmacological modulation of voltage-gated potassium channels as a therapeutic strategy.Novel Kv1.3 blockers for immunosuppression: WO2012155199.Treating autoimmune disorders with venom-derived peptides.Kv1.1 channelopathy abolishes presynaptic spike width modulation by subthreshold somatic depolarization.Spiro azepane-oxazolidinones as Kv1.3 potassium channel blockers: WO2010066840.State-dependent blocking mechanism of Kv 1.3 channels by the antimycobacterial drug clofazimine.Altered outward-rectifying K(+) current reveals microglial activation induced by HIV-1 Tat protein.Identification of novel Kv1.3 blockers using a fluorescent cell-based ion channel assay.Immunosuppressive effects of subglutinol derivatives.
P2860
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P2860
UK-78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage-gated potassium channel and inhibits human T cell activation.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh-hant
name
UK-78,282, a novel piperidine ...... ibits human T cell activation.
@en
UK-78,282, a novel piperidine ...... ibits human T cell activation.
@nl
type
label
UK-78,282, a novel piperidine ...... ibits human T cell activation.
@en
UK-78,282, a novel piperidine ...... ibits human T cell activation.
@nl
prefLabel
UK-78,282, a novel piperidine ...... ibits human T cell activation.
@en
UK-78,282, a novel piperidine ...... ibits human T cell activation.
@nl
P2093
P2860
P356
P1476
UK-78,282, a novel piperidine ...... ibits human T cell activation.
@en
P2093
A C Cunningham
C B Donovan
D C Hanson
G A Gutman
K A Verdries
P2860
P304
P356
10.1038/SJ.BJP.0702480
P407
P577
1999-04-01T00:00:00Z