Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice
about
Transthyretin and the brain re-visited: is neuronal synthesis of transthyretin protective in Alzheimer's disease?Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor proteinPresenilin-1 regulates the expression of p62 to govern p62-dependent tau degradationNeurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratioSEL-10 interacts with presenilin 1, facilitates its ubiquitination, and alters A-beta peptide productionThe novel presenilin-1-associated protein is a proapoptotic mitochondrial proteinInteraction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer diseaseDissecting the pathological effects of human Abeta40 and Abeta42 in Drosophila: a potential model for Alzheimer's diseaseThe gene encoding nicastrin, a major gamma-secretase component, modifies risk for familial early-onset Alzheimer disease in a Dutch population-based sampleDifferential processing of amyloid-beta precursor protein directs human embryonic stem cell proliferation and differentiation into neuronal precursor cellsAmyloids: friend or foe?Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's diseasePhosphorylation of presenilin-2 regulates its cleavage by caspases and retards progression of apoptosisWhen loss is gain: reduced presenilin proteolytic function leads to increased Abeta42/Abeta40. Talking Point on the role of presenilin mutations in Alzheimer diseasePin1 in Alzheimer's disease: multiple substrates, one regulatory mechanism?Inflammatory cytokine levels correlate with amyloid load in transgenic mouse models of Alzheimer's diseaseThe presenilinsTau Protein Hyperphosphorylation and Aggregation in Alzheimer's Disease and Other Tauopathies, and Possible Neuroprotective StrategiesProteomics in Traditional Chinese Medicine with an Emphasis on Alzheimer's DiseaseAlzheimer's Disease: Mechanism and Approach to Cell TherapyA Unified Hypothesis of Early- and Late-Onset Alzheimer's Disease PathogenesisThe endocrine dyscrasia that accompanies menopause and andropause induces aberrant cell cycle signaling that triggers re-entry of post-mitotic neurons into the cell cycle, neurodysfunction, neurodegeneration and cognitive diseaseMutations in presenilin 2 and its implications in Alzheimer's disease and other dementia-associated disordersBehavioral assays with mouse models of Alzheimer's disease: practical considerations and guidelines.Toward the structure of presenilin/γ-secretase and presenilin homologsInconsistencies and controversies surrounding the amyloid hypothesis of Alzheimer's diseaseStructural evolution and membrane interactions of Alzheimer's amyloid-beta peptide oligomers: new knowledge from single-molecule fluorescence studiesCD4 T cells in immunity and immunotherapy of Alzheimer's diseaseLysosome and calcium dysregulation in Alzheimer's disease: partners in crimeGenetic variants associated with neurodegenerative Alzheimer disease in natural modelsCurrent and future implications of basic and translational research on amyloid-β peptide production and removal pathwaysPresenilins interact with armadillo proteins including neural-specific plakophilin-related protein and beta-cateninAlzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzymeβ-secretase inhibitor; a promising novel therapeutic drug in Alzheimer's diseaseEndoproteolytic processing and stabilization of wild-type and mutant presenilinPresenilin clinical mutations can affect gamma-secretase activity by different mechanismsThe glutamatergic system and neurodegeneration in dementia: preventive strategies in Alzheimer's diseaseLysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutationsPresenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain
P2860
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P2860
Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice
description
1997 nî lūn-bûn
@nan
1997 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Mutant presenilins of Alzheime ...... cted cells and transgenic mice
@ast
Mutant presenilins of Alzheime ...... cted cells and transgenic mice
@en
Mutant presenilins of Alzheime ...... cted cells and transgenic mice
@nl
type
label
Mutant presenilins of Alzheime ...... cted cells and transgenic mice
@ast
Mutant presenilins of Alzheime ...... cted cells and transgenic mice
@en
Mutant presenilins of Alzheime ...... cted cells and transgenic mice
@nl
prefLabel
Mutant presenilins of Alzheime ...... cted cells and transgenic mice
@ast
Mutant presenilins of Alzheime ...... cted cells and transgenic mice
@en
Mutant presenilins of Alzheime ...... cted cells and transgenic mice
@nl
P2093
P3181
P356
P1433
P1476
Mutant presenilins of Alzheime ...... cted cells and transgenic mice
@en
P2093
D J Selkoe
D Kholodenko
D Westaway
G Levesque
I Lieberburg
P2860
P2888
P3181
P356
10.1038/NM0197-67
P407
P577
1997-01-01T00:00:00Z
P6179
1038157044