The Ras GTPase-activating protein (GAP) is an SH3 domain-binding protein and substrate for the Src-related tyrosine kinase, Hck
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The kinase, SH3, and SH2 domains of Lck play critical roles in T-cell activation after ZAP-70 membrane localizationCo-expression with BCR induces activation of the FES tyrosine kinase and phosphorylation of specific N-terminal BCR tyrosine residuesTransformation of myeloid leukemia cells to cytokine independence by Bcr-Abl is suppressed by kinase-defective HckDifferential actions of p60c-Src and Lck kinases on the Ras regulators p120-GAP and GDP/GTP exchange factor CDC25MmPhysical and functional interaction between Hck tyrosine kinase and guanine nucleotide exchange factor C3G results in apoptosis, which is independent of C3G catalytic domainSam68 associates with the SH3 domains of Grb2 recruiting GAP to the Grb2-SOS complex in insulin receptor signalingG3BP1 contributes to tumor metastasis via upregulation of Slug expression in hepatocellular carcinomaPartial cooperative unfolding in proteins as observed by hydrogen exchange mass spectrometry.Activation of STAT3 by the Src family kinase Hck requires a functional SH3 domain.RasGAP is involved in signal transduction triggered by FGF1 in Xenopus oocytes expressing FGFR1.Interaction of the N-methyl-D-aspartic acid receptor NR2D subunit with the c-Abl tyrosine kinase.Src-like adaptor protein (SLAP) is a negative regulator of T cell receptor signalingSH2-kinase linker mutations release Hck tyrosine kinase and transforming activities in Rat-2 fibroblasts.Proline-rich motifs of the Na+/H+ exchanger 2 isoform. Binding of Src homology domain 3 and role in apical targeting in epithelia.The lck SH3 domain is required for activation of the mitogen-activated protein kinase pathway but not the initiation of T-cell antigen receptor signaling.Genetic evidence of a role for Lck in T-cell receptor function independent or downstream of ZAP-70/Syk protein tyrosine kinases.Network screening of Goto-Kakizaki rat liver microarray data during diabetic progression.Control of growth and differentiation by Drosophila RasGAP, a homolog of p120 Ras-GTPase-activating protein.The Src tyrosine kinase Hck is required for Tel-Abl- but not for Tel-Jak2-induced cell transformation.Mercuric chloride activates the Src-family protein tyrosine kinase, Hck in myelomonocytic cells.Gp130-mediated signal transduction in embryonic stem cells involves activation of Jak and Ras/mitogen-activated protein kinase pathways.Oligomerization of the Fes tyrosine kinase. Evidence for a coiled-coil domain in the unique N-terminal region.Autophosphorylation of the Fes tyrosine kinase. Evidence for an intermolecular mechanism involving two kinase domain tyrosine residues.A positive feedback loop between Gli1 and tyrosine kinase Hck amplifies shh signaling activities in medulloblastomaPlatelet-derived growth factor-dependent association of the GTPase-activating protein of Ras and Src.Angiotensin II Controls p21 Activity via pp60The RasGAP N-terminal Fragment Generated by Caspase Cleavage Protects Cells in a Ras/PI3K/Akt-dependent Manner That Does Not Rely on NFκB Activation
P2860
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P2860
The Ras GTPase-activating protein (GAP) is an SH3 domain-binding protein and substrate for the Src-related tyrosine kinase, Hck
description
1995 nî lūn-bûn
@nan
1995 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
The Ras GTPase-activating prot ...... c-related tyrosine kinase, Hck
@ast
The Ras GTPase-activating prot ...... c-related tyrosine kinase, Hck
@en
The Ras GTPase-activating prot ...... c-related tyrosine kinase, Hck
@nl
type
label
The Ras GTPase-activating prot ...... c-related tyrosine kinase, Hck
@ast
The Ras GTPase-activating prot ...... c-related tyrosine kinase, Hck
@en
The Ras GTPase-activating prot ...... c-related tyrosine kinase, Hck
@nl
prefLabel
The Ras GTPase-activating prot ...... c-related tyrosine kinase, Hck
@ast
The Ras GTPase-activating prot ...... c-related tyrosine kinase, Hck
@en
The Ras GTPase-activating prot ...... c-related tyrosine kinase, Hck
@nl
P2093
P2860
P356
P1476
The Ras GTPase-activating prot ...... c-related tyrosine kinase, Hck
@en
P2093
S D Sanderson
S S Bryant
T E Smithgall
P2860
P304
14718-14724
P356
10.1074/JBC.270.24.14718
P407
P577
1995-06-01T00:00:00Z